ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients

Simone Cesaro; Tina Dalianis; Christine Hanssen Rinaldo; Minna Koskenvuo; Anna Pegoraro; Hermann Einsele; Catherine Cordonnier; Hans H. Hirsch; Murat Akova; Mahmoud Aljurf; Dina Averbuch; Rosemary Barnes; Ola Blennow; Pierre-Yves Bochud; Emilio Bouza; Stephane Bretagne; Roger Brüggemann; Thierry Calandra; Jordi Carratala; Oliver Cornely; Rafael De La Camara; Peter Donnelly; Lubos Drgona; Rafael Duarte; Dan Engelhard; Christopher Fox; Corrado Girmenia; Andreas Groll; Dag Heldal; Jannick Helweg-Larsen; Raoul Herbrecht; Elisabeth Johnson; Galina Klyasova; Katrien Lagrou; Russell E. Lewis; Per Ljungman; Johan Maertens; Malgorzata Mikulska; Marcio Nucci; Christophe Padoin; Livio Pagano; Antonio Pagliuca; Zdenek Racil; Patricia Ribaud; Valérie Rizzi-Puechal; Emmanuel Roilides; Christine Robin; Montserrat Rovira; Markus Rupp; Sonia Sanchez; Peter Schellongowski; Peter Sedlacek; Janos Sinko; Monica Slavin; Isabella Sousa Ferreira; Jan Styczynski; Frederic Tissot; Claudio Viscoli; Katherine Ward; Anne-Therese Witschi

doi:10.1093/jac/dkx324

ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients

Simone Cesaro, Tina Dalianis, Christine Hanssen Rinaldo, Minna Koskenvuo, Anna Pegoraro, Hermann Einsele, Catherine Cordonnier, Hans H. Hirsch, Murat Akova, Mahmoud Aljurf, Dina Averbuch, Rosemary Barnes, Ola Blennow, Pierre-Yves Bochud, Emilio Bouza, Stephane Bretagne, Roger Brüggemann, Thierry Calandra, Jordi Carratala, Oliver CornelyRafael De La Camara, Peter Donnelly, Lubos Drgona, Rafael Duarte, Dan Engelhard, Christopher Fox, Corrado Girmenia, Andreas Groll, Dag Heldal, Jannick Helweg-Larsen, Raoul Herbrecht, Elisabeth Johnson, Galina Klyasova, Katrien Lagrou, Russell E. Lewis, Per Ljungman, Johan Maertens, Malgorzata Mikulska, Marcio Nucci, Christophe Padoin, Livio Pagano, Antonio Pagliuca, Zdenek Racil, Patricia Ribaud, Valérie Rizzi-Puechal, Emmanuel Roilides, Christine Robin, Montserrat Rovira, Markus Rupp, Sonia Sanchez, Peter Schellongowski, Peter Sedlacek, Janos Sinko, Monica Slavin, Isabella Sousa Ferreira, Jan Styczynski, Frederic Tissot, Claudio Viscoli, Katherine Ward, Anne-Therese Witschi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

54 Citazioni (Scopus)

Abstract

Objectives: To define guidelines for BK polyomavirus (BKPyV)-associated haemorrhagic cystitis (BKPyV-HC) after paediatric and adult HSCT. Methods: Review of English literature and evidence-based recommendations by expert consensus. Results: BKPyV-HC occurs in 8%-25%of paediatric and 7%-54%of adult recipients undergoing allogeneic HSCT. Diagnosis requires the triad of cystitis, macro-haematuria and high urine BKPyV loads > 7 log10copies/mL, and exclusion of other relevant aetiologies. BKPyV viraemia is frequent and may serve as a more specific semiquantitative follow-up marker. No randomized controlled trials are available to inform antiviral prophylaxis or treatment. However, hyper-hydration and/or bladder irrigation showed limited prophylactic value. Fluoroquinolones are not effective for prophylaxis or treatment, but rather increase antibiotic resistance. Hyperbaric oxygen or fibrin glue is marginally effective based on small case series from correspondingly equipped centres. Although cidofovir has been reported to improve and/or reduce BKPyV viraemia or viruria, the current data do not support its regular use. Conclusions: BKPyV-HC remains a disabling unmet clinical need in HSCT that requires novel approaches supported by proper clinical trials.

Lingua originale	English
pagine (da-a)	12-21
Numero di pagine	10
Rivista	Journal of Antimicrobial Chemotherapy
Volume	73
DOI	https://doi.org/10.1093/jac/dkx324
Stato di pubblicazione	Pubblicato - 2018

Keywords

Infectious Diseases
Pharmacology
Pharmacology (medical)

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Cesaro, S., Dalianis, T., Rinaldo, C. H., Koskenvuo, M., Pegoraro, A., Einsele, H., Cordonnier, C., Hirsch, H. H., Akova, M., Aljurf, M., Averbuch, D., Barnes, R., Blennow, O., Bochud, P-Y., Bouza, E., Bretagne, S., Brüggemann, R., Calandra, T., Carratala, J., ... Witschi, A-T. (2018). ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients. Journal of Antimicrobial Chemotherapy, 73, 12-21. https://doi.org/10.1093/jac/dkx324

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title = "ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients",

abstract = "Objectives: To define guidelines for BK polyomavirus (BKPyV)-associated haemorrhagic cystitis (BKPyV-HC) after paediatric and adult HSCT. Methods: Review of English literature and evidence-based recommendations by expert consensus. Results: BKPyV-HC occurs in 8%-25%of paediatric and 7%-54%of adult recipients undergoing allogeneic HSCT. Diagnosis requires the triad of cystitis, macro-haematuria and high urine BKPyV loads > 7 log10copies/mL, and exclusion of other relevant aetiologies. BKPyV viraemia is frequent and may serve as a more specific semiquantitative follow-up marker. No randomized controlled trials are available to inform antiviral prophylaxis or treatment. However, hyper-hydration and/or bladder irrigation showed limited prophylactic value. Fluoroquinolones are not effective for prophylaxis or treatment, but rather increase antibiotic resistance. Hyperbaric oxygen or fibrin glue is marginally effective based on small case series from correspondingly equipped centres. Although cidofovir has been reported to improve and/or reduce BKPyV viraemia or viruria, the current data do not support its regular use. Conclusions: BKPyV-HC remains a disabling unmet clinical need in HSCT that requires novel approaches supported by proper clinical trials.",

keywords = "Infectious Diseases, Pharmacology, Pharmacology (medical), Infectious Diseases, Pharmacology, Pharmacology (medical)",

author = "Simone Cesaro and Tina Dalianis and Rinaldo, {Christine Hanssen} and Minna Koskenvuo and Anna Pegoraro and Hermann Einsele and Catherine Cordonnier and Hirsch, {Hans H.} and Murat Akova and Mahmoud Aljurf and Dina Averbuch and Rosemary Barnes and Ola Blennow and Pierre-Yves Bochud and Emilio Bouza and Stephane Bretagne and Roger Br{\"u}ggemann and Thierry Calandra and Jordi Carratala and Oliver Cornely and {De La Camara}, Rafael and Peter Donnelly and Lubos Drgona and Rafael Duarte and Dan Engelhard and Christopher Fox and Corrado Girmenia and Andreas Groll and Dag Heldal and Jannick Helweg-Larsen and Raoul Herbrecht and Elisabeth Johnson and Galina Klyasova and Katrien Lagrou and Lewis, {Russell E.} and Per Ljungman and Johan Maertens and Malgorzata Mikulska and Marcio Nucci and Christophe Padoin and Livio Pagano and Antonio Pagliuca and Zdenek Racil and Patricia Ribaud and Val{\'e}rie Rizzi-Puechal and Emmanuel Roilides and Christine Robin and Montserrat Rovira and Markus Rupp and Sonia Sanchez and Peter Schellongowski and Peter Sedlacek and Janos Sinko and Monica Slavin and Ferreira, {Isabella Sousa} and Jan Styczynski and Frederic Tissot and Claudio Viscoli and Katherine Ward and Anne-Therese Witschi",

year = "2018",

doi = "10.1093/jac/dkx324",

language = "English",

volume = "73",

pages = "12--21",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485",

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Cesaro, S, Dalianis, T, Rinaldo, CH, Koskenvuo, M, Pegoraro, A, Einsele, H, Cordonnier, C, Hirsch, HH, Akova, M, Aljurf, M, Averbuch, D, Barnes, R, Blennow, O, Bochud, P-Y, Bouza, E, Bretagne, S, Brüggemann, R, Calandra, T, Carratala, J, Cornely, O, De La Camara, R, Donnelly, P, Drgona, L, Duarte, R, Engelhard, D, Fox, C, Girmenia, C, Groll, A, Heldal, D, Helweg-Larsen, J, Herbrecht, R, Johnson, E, Klyasova, G, Lagrou, K, Lewis, RE, Ljungman, P, Maertens, J, Mikulska, M, Nucci, M, Padoin, C, Pagano, L, Pagliuca, A, Racil, Z, Ribaud, P, Rizzi-Puechal, V, Roilides, E, Robin, C, Rovira, M, Rupp, M, Sanchez, S, Schellongowski, P, Sedlacek, P, Sinko, J, Slavin, M, Ferreira, IS, Styczynski, J, Tissot, F, Viscoli, C, Ward, K & Witschi, A-T 2018, 'ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients', Journal of Antimicrobial Chemotherapy, vol. 73, pagg. 12-21. https://doi.org/10.1093/jac/dkx324

ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients. / Cesaro, Simone; Dalianis, Tina; Rinaldo, Christine Hanssen et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 73, 2018, pag. 12-21.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients

AU - Cesaro, Simone

AU - Dalianis, Tina

AU - Rinaldo, Christine Hanssen

AU - Koskenvuo, Minna

AU - Pegoraro, Anna

AU - Einsele, Hermann

AU - Cordonnier, Catherine

AU - Hirsch, Hans H.

AU - Akova, Murat

AU - Aljurf, Mahmoud

AU - Averbuch, Dina

AU - Barnes, Rosemary

AU - Blennow, Ola

AU - Bochud, Pierre-Yves

AU - Bouza, Emilio

AU - Bretagne, Stephane

AU - Brüggemann, Roger

AU - Calandra, Thierry

AU - Carratala, Jordi

AU - Cornely, Oliver

AU - De La Camara, Rafael

AU - Donnelly, Peter

AU - Drgona, Lubos

AU - Duarte, Rafael

AU - Engelhard, Dan

AU - Fox, Christopher

AU - Girmenia, Corrado

AU - Groll, Andreas

AU - Heldal, Dag

AU - Helweg-Larsen, Jannick

AU - Herbrecht, Raoul

AU - Johnson, Elisabeth

AU - Klyasova, Galina

AU - Lagrou, Katrien

AU - Lewis, Russell E.

AU - Ljungman, Per

AU - Maertens, Johan

AU - Mikulska, Malgorzata

AU - Nucci, Marcio

AU - Padoin, Christophe

AU - Pagano, Livio

AU - Pagliuca, Antonio

AU - Racil, Zdenek

AU - Ribaud, Patricia

AU - Rizzi-Puechal, Valérie

AU - Roilides, Emmanuel

AU - Robin, Christine

AU - Rovira, Montserrat

AU - Rupp, Markus

AU - Sanchez, Sonia

AU - Schellongowski, Peter

AU - Sedlacek, Peter

AU - Sinko, Janos

AU - Slavin, Monica

AU - Ferreira, Isabella Sousa

AU - Styczynski, Jan

AU - Tissot, Frederic

AU - Viscoli, Claudio

AU - Ward, Katherine

AU - Witschi, Anne-Therese

PY - 2018

Y1 - 2018

N2 - Objectives: To define guidelines for BK polyomavirus (BKPyV)-associated haemorrhagic cystitis (BKPyV-HC) after paediatric and adult HSCT. Methods: Review of English literature and evidence-based recommendations by expert consensus. Results: BKPyV-HC occurs in 8%-25%of paediatric and 7%-54%of adult recipients undergoing allogeneic HSCT. Diagnosis requires the triad of cystitis, macro-haematuria and high urine BKPyV loads > 7 log10copies/mL, and exclusion of other relevant aetiologies. BKPyV viraemia is frequent and may serve as a more specific semiquantitative follow-up marker. No randomized controlled trials are available to inform antiviral prophylaxis or treatment. However, hyper-hydration and/or bladder irrigation showed limited prophylactic value. Fluoroquinolones are not effective for prophylaxis or treatment, but rather increase antibiotic resistance. Hyperbaric oxygen or fibrin glue is marginally effective based on small case series from correspondingly equipped centres. Although cidofovir has been reported to improve and/or reduce BKPyV viraemia or viruria, the current data do not support its regular use. Conclusions: BKPyV-HC remains a disabling unmet clinical need in HSCT that requires novel approaches supported by proper clinical trials.

AB - Objectives: To define guidelines for BK polyomavirus (BKPyV)-associated haemorrhagic cystitis (BKPyV-HC) after paediatric and adult HSCT. Methods: Review of English literature and evidence-based recommendations by expert consensus. Results: BKPyV-HC occurs in 8%-25%of paediatric and 7%-54%of adult recipients undergoing allogeneic HSCT. Diagnosis requires the triad of cystitis, macro-haematuria and high urine BKPyV loads > 7 log10copies/mL, and exclusion of other relevant aetiologies. BKPyV viraemia is frequent and may serve as a more specific semiquantitative follow-up marker. No randomized controlled trials are available to inform antiviral prophylaxis or treatment. However, hyper-hydration and/or bladder irrigation showed limited prophylactic value. Fluoroquinolones are not effective for prophylaxis or treatment, but rather increase antibiotic resistance. Hyperbaric oxygen or fibrin glue is marginally effective based on small case series from correspondingly equipped centres. Although cidofovir has been reported to improve and/or reduce BKPyV viraemia or viruria, the current data do not support its regular use. Conclusions: BKPyV-HC remains a disabling unmet clinical need in HSCT that requires novel approaches supported by proper clinical trials.

KW - Infectious Diseases

KW - Pharmacology

KW - Pharmacology (medical)

KW - Infectious Diseases

KW - Pharmacology

KW - Pharmacology (medical)

UR - http://hdl.handle.net/10807/111929

UR - http://jac.oxfordjournals.org/

U2 - 10.1093/jac/dkx324

DO - 10.1093/jac/dkx324

M3 - Article

SN - 0305-7453

VL - 73

SP - 12

EP - 21

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

ER -

ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients

Abstract

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