Early vasoreactive profile of skeletonized versus pedicled internal thoracic artery grafts

Carlo Trani, Mario Fulvio Luigi Gaudino, Franco Glieca, Francesco Alessandrini, Giovanni Schiavoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)


Background: No data are available on the early vasoreactive profile of skeletonized internal thoracic artery grafts. Methods: Fifteen patients undergoing primary isolated coronary artery bypass grafting were randomly assigned to receive a skeletonized or pedicled internal thoracic artery graft. On the second postoperative day all patients were subjected to follow-up angiography and endovascular infusion of serotonin, acetylcholine, and isosorbide dinitrate. Results: Internal thoracic artery grafts were widely patent in all cases. Mean diameters of the internal thoracic artery were 1.95 ± 0.17 mm in the pedicled group and 2.26 ± 0.40 mm in the skeletonized group. After serotonin challenge, mean internal thoracic artery diameters were reduced to 1.44 ± 0.34 mm and 1.64 ± 0.14 mm, respectively; acetylcholine challenge lead to a moderate degree of vasoconstriction (1.55 ± 0.59 mm in the pedicled group and 1.84 ± 0.15 mm in the skeletonized group). No statistically significant difference was evident between the two groups at any step. Conclusion: Skeletonization does not affect the early vasoreactive profile of internal thoracic artery grafts used for surgical myocardial revascularization.
Lingua originaleEnglish
pagine (da-a)638-641
Numero di pagine4
RivistaJournal of Thoracic and Cardiovascular Surgery
Stato di pubblicazionePubblicato - 2003


  • Acetylcholine
  • Aged
  • Coronary Angiography
  • Dissection
  • Female
  • Humans
  • Internal Mammary-Coronary Artery Anastomosis
  • Isosorbide Dinitrate
  • Male
  • Middle Aged
  • Serotonin
  • Surgical Flaps
  • Thoracic Arteries
  • Tissue and Organ Harvesting
  • Treatment Outcome
  • Vascular Patency
  • Vasoconstriction
  • Vasodilation
  • Vasodilator Agents


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