Early-stage cervical cancer: tumor delineation by magnetic resonance imaging and ultrasound - a European multicenter trial

Antonia Carla Testa, Gian Franco Zannoni, Alessia Di Legge, Anna Lia Valentini, Benedetta Gui, Elisabeth Epstein, Adrius Gaurilcikas, Liveke Ameye, Vaida Atstupenaite, Nils-Olof Wallengren, Sonja Pudaric, Arvydas Cizauskas, Anna Måsbäck, Päivi Kannisto, Michal Zikan, Ivana Pinkavova, Andrea Burgetova, Pavel Dundr, Kristyna Nemejcova, David CibulaDaniela Fischerova

Risultato della ricerca: Contributo in rivistaArticolo in rivista

89 Citazioni (Scopus)


Objective. To compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) in the preoperative assessment of early-stage cervical cancer using pathologic findings as the reference standard. Patients and methods. Prospectivemulti-center trial enrolling 209 consecutivewomen with early-stage cervical cancer (FIGO IA2–IIA) scheduled for surgery. The following parameterswere assessed on US andMRI and compared to pathology: remaining tumor, size, tumor stromal invasionb2/3 (superficial) or ≥2/3 (deep), and parametrial invasion. Results. Complete data were available for 182 patients. The agreement between US and pathologywas excellent for detecting tumors, correctly classifying bulky tumors (>4 cm), and detecting deep stromal invasion (kappa values 0.84, 0.82, and 0.81 respectively); and good for classifying small tumors (b2 cm) and detecting parametrial invasion (kappa values 0.78 and 0.75, respectively). The agreement between MRI and histology was good for classifying tumors as b2 cm, or >4 cm, and detecting deep stromal invasion (kappa values 0.71, 0.76, and 0.77, respectively). It was moderately accurate in tumor detection, and in assessing parametrial invasion (kappa values 0.52 and 0.45, respectively). The agreement between histology and US was significantly better in assessing residual tumor (pb0.001) and parametrial invasion (pb0.001) than the results obtained by MRI. Imaging methods were not significantly influenced by previous cone biopsy.
Lingua originaleEnglish
pagine (da-a)449-453
Numero di pagine4
RivistaGynecologic Oncology
Stato di pubblicazionePubblicato - 2013


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