Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters

Edy Ippolito; Francesco Deodato; Gabriella Macchia; Mariangela Massaccesi; Cinzia Digesu'; Ga Pirozzi; Gianluca Spera; Stefani Marangi; E Annoscia; Savino Cilla; Angelo Piermattei; Vincenzo Valentini; Numa Cellini; Marcello Ingrosso; Alessio Giuseppe Morganti

doi:10.1016/j.radonc.2012.05.010

Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters

Edy Ippolito, Francesco Deodato, Gabriella Macchia, Mariangela Massaccesi, Cinzia Digesu', Ga Pirozzi, Gianluca Spera, Stefani Marangi, E Annoscia, Savino Cilla, Angelo Piermattei, Vincenzo Valentini, Numa Cellini, Marcello Ingrosso, Alessio Giuseppe Morganti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

BACKGROUND AND PURPOSE: Late rectal complications are assessed according to different scoring systems. Endoscopy can provide a more sensitive estimation of early radiation damage. The aim of this paper is to investigate the correlation between dosimetric parameters and rectal mucosal changes after radiotherapy (RT). MATERIALS AND METHODS: Patients with prostate adenocarcinoma treated with curative or adjuvant RT underwent endoscopy 1year after RT. Receiver operating characteristics (ROC) analysis was performed to analyze the predictive capability of the dosimetric variables in determining mucosal changes classified by Vienna Rectoscopy Score (VRS). RESULTS: The best dosimetric predictors of grade ⩾2 telangiectasia were rectal (r) V(60 Gy) (p=0.014), rV(70 Gy) (p=0.017) and rD(mean) (p=0.018). Similar results were obtained for grade ⩾2 VRS. The set of rV(60 Gy)<34.4%, rV(70 Gy)<16.7% and rD(mean)<57.5Gy was associated with a decreased risk of grade ⩾2 telangiectasia and VRS. CONCLUSIONS: rV(60 Gy), rV(70 Gy) and rD(mean) were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.

Lingua originale	English
pagine (da-a)	103-108
Numero di pagine	6
Rivista	Radiotherapy and Oncology
Volume	104(1)
DOI	https://doi.org/10.1016/j.radonc.2012.05.010
Stato di pubblicazione	Pubblicato - 2012

Keywords

dosimetry

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10.1016/j.radonc.2012.05.010

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Ippolito, E., Deodato, F., Macchia, G., Massaccesi, M., Digesu', C., Pirozzi, G., Spera, G., Marangi, S., Annoscia, E., Cilla, S., Piermattei, A., Valentini, V., Cellini, N., Ingrosso, M., & Morganti, A. G. (2012). Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters. Radiotherapy and Oncology, 104(1), 103-108. https://doi.org/10.1016/j.radonc.2012.05.010

@article{60945d6c8e9a4cb9b63e74e54fcd4a91,

title = "Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters",

abstract = "BACKGROUND AND PURPOSE: Late rectal complications are assessed according to different scoring systems. Endoscopy can provide a more sensitive estimation of early radiation damage. The aim of this paper is to investigate the correlation between dosimetric parameters and rectal mucosal changes after radiotherapy (RT). MATERIALS AND METHODS: Patients with prostate adenocarcinoma treated with curative or adjuvant RT underwent endoscopy 1year after RT. Receiver operating characteristics (ROC) analysis was performed to analyze the predictive capability of the dosimetric variables in determining mucosal changes classified by Vienna Rectoscopy Score (VRS). RESULTS: The best dosimetric predictors of grade ⩾2 telangiectasia were rectal (r) V(60 Gy) (p=0.014), rV(70 Gy) (p=0.017) and rD(mean) (p=0.018). Similar results were obtained for grade ⩾2 VRS. The set of rV(60 Gy)<34.4%, rV(70 Gy)<16.7% and rD(mean)<57.5Gy was associated with a decreased risk of grade ⩾2 telangiectasia and VRS. CONCLUSIONS: rV(60 Gy), rV(70 Gy) and rD(mean) were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.",

keywords = "dosimetry, dosimetry",

author = "Edy Ippolito and Francesco Deodato and Gabriella Macchia and Mariangela Massaccesi and Cinzia Digesu' and Ga Pirozzi and Gianluca Spera and Stefani Marangi and E Annoscia and Savino Cilla and Angelo Piermattei and Vincenzo Valentini and Numa Cellini and Marcello Ingrosso and Morganti, {Alessio Giuseppe}",

year = "2012",

doi = "10.1016/j.radonc.2012.05.010",

language = "English",

volume = "104(1)",

pages = "103--108",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114",

}

Ippolito, E, Deodato, F, Macchia, G, Massaccesi, M, Digesu', C, Pirozzi, G, Spera, G, Marangi, S, Annoscia, E, Cilla, S, Piermattei, A, Valentini, V, Cellini, N, Ingrosso, M & Morganti, AG 2012, 'Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters', Radiotherapy and Oncology, vol. 104(1), pagg. 103-108. https://doi.org/10.1016/j.radonc.2012.05.010

TY - JOUR

T1 - Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters

AU - Ippolito, Edy

AU - Deodato, Francesco

AU - Macchia, Gabriella

AU - Massaccesi, Mariangela

AU - Digesu', Cinzia

AU - Pirozzi, Ga

AU - Spera, Gianluca

AU - Marangi, Stefani

AU - Annoscia, E

AU - Cilla, Savino

AU - Piermattei, Angelo

AU - Valentini, Vincenzo

AU - Cellini, Numa

AU - Ingrosso, Marcello

AU - Morganti, Alessio Giuseppe

PY - 2012

Y1 - 2012

N2 - BACKGROUND AND PURPOSE: Late rectal complications are assessed according to different scoring systems. Endoscopy can provide a more sensitive estimation of early radiation damage. The aim of this paper is to investigate the correlation between dosimetric parameters and rectal mucosal changes after radiotherapy (RT). MATERIALS AND METHODS: Patients with prostate adenocarcinoma treated with curative or adjuvant RT underwent endoscopy 1year after RT. Receiver operating characteristics (ROC) analysis was performed to analyze the predictive capability of the dosimetric variables in determining mucosal changes classified by Vienna Rectoscopy Score (VRS). RESULTS: The best dosimetric predictors of grade ⩾2 telangiectasia were rectal (r) V(60 Gy) (p=0.014), rV(70 Gy) (p=0.017) and rD(mean) (p=0.018). Similar results were obtained for grade ⩾2 VRS. The set of rV(60 Gy)<34.4%, rV(70 Gy)<16.7% and rD(mean)<57.5Gy was associated with a decreased risk of grade ⩾2 telangiectasia and VRS. CONCLUSIONS: rV(60 Gy), rV(70 Gy) and rD(mean) were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.

AB - BACKGROUND AND PURPOSE: Late rectal complications are assessed according to different scoring systems. Endoscopy can provide a more sensitive estimation of early radiation damage. The aim of this paper is to investigate the correlation between dosimetric parameters and rectal mucosal changes after radiotherapy (RT). MATERIALS AND METHODS: Patients with prostate adenocarcinoma treated with curative or adjuvant RT underwent endoscopy 1year after RT. Receiver operating characteristics (ROC) analysis was performed to analyze the predictive capability of the dosimetric variables in determining mucosal changes classified by Vienna Rectoscopy Score (VRS). RESULTS: The best dosimetric predictors of grade ⩾2 telangiectasia were rectal (r) V(60 Gy) (p=0.014), rV(70 Gy) (p=0.017) and rD(mean) (p=0.018). Similar results were obtained for grade ⩾2 VRS. The set of rV(60 Gy)<34.4%, rV(70 Gy)<16.7% and rD(mean)<57.5Gy was associated with a decreased risk of grade ⩾2 telangiectasia and VRS. CONCLUSIONS: rV(60 Gy), rV(70 Gy) and rD(mean) were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.

KW - dosimetry

UR - http://hdl.handle.net/10807/32838

U2 - 10.1016/j.radonc.2012.05.010

DO - 10.1016/j.radonc.2012.05.010

M3 - Article

SN - 0167-8140

VL - 104(1)

SP - 103

EP - 108

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters

Abstract

Keywords

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