Early prenatal diagnosis and therapy of fetal hypothyroid goiter

Marco De Santis, Lucia Masini, Salvatore Mancuso, Giuseppe Noia, Giovanni Francesco Livio D'Errico, Alfredo Bianchi, Costantino Romagnoli, Alessandro Caruso, A Tocci, Ml Maussier

Risultato della ricerca: Contributo in rivistaArticolo in rivista

26 Citazioni (Scopus)

Abstract

We report a case of early diagnosis of iodide-induced fetal hypothyroidism at 22 weeks of gestation, confirmed at 29 weeks by cordocentesis and successfully treated intra-amniotically. The ultrasonographic feature was the presence of two echogenic masses in the fetal neck; polyhydramnios was absent. Mild hypothyroidism was diagnosed based on fetal serum obtained by percutaneous umbilical blood sampling at 29 weeks of gestation. The persistence of fetal hypothyroidism in spite of maternal thyroid improvement was confirmed by a second cordocentesis at 35 weeks of gestation, and a single injection of intra-amniotic levothyroxine (250 micrograms) was performed. The serial ultrasonographic examinations showed disappearance of the fetal goiter. A healthy female baby (3,630 g) was delivered at term. At birth, the thyroid gland was not enlarged, and neonatal thyroid hormones were within the normal range. This case suggests that cordocentesis is a reliable method to assess the fetal thyroid status; moreover a single injection of intra-amniotic thyroxine was effective in treating fetal hypothyroid goiter.
Lingua originaleEnglish
pagine (da-a)138-143
Numero di pagine6
RivistaFetal Diagnosis and Therapy
Volume7
Stato di pubblicazionePubblicato - 1992

Keywords

  • Adult
  • Amniotic Fluid
  • Congenital Hypothyroidism
  • Female
  • Fetal Diseases
  • Goiter
  • Humans
  • Hypothyroidism
  • Infant, Newborn
  • Pregnancy
  • Prenatal Diagnosis
  • Thyroid Hormones
  • Thyroxine

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