Early-onset myasthenia gravis: clinical characteristics and response to therapy

Anna Paola Batocchi, Amelia Evoli Stampanoni-B, Mt Palmisani, Mauro Lo Monaco, Emanuela Bartoccioni, Pietro Attilio Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

48 Citazioni (Scopus)


We studied 59 children with myasthenia gravis (MG). Disease onset was pre-pubertal in 26 patients and post-pubertal in 33. The male to female ratio was 0.62 in the early- and 0.17 in the late-onset groups. The frequency of ocular MG was higher in patients with prepubertal onset. Patients with generalized MG generally showed a good response to thymectomy and corticosteroid therapy proved effective with no major side-effects. In our experience early-onset MG has the same course as in adult life. We recommend thymectomy for generalized disease in childhood, except in very young children on account of possible long-term effects on immunological development. Immunosuppressive therapy should be considered in severely affected patients who do not respond adequately to other therapies.
Lingua originaleEnglish
pagine (da-a)66-68
Numero di pagine3
RivistaEuropean Journal of Pediatrics
Stato di pubblicazionePubblicato - 1990


  • Age Factors
  • Child
  • Infant
  • Myasthenia Gravis
  • Plasma Exchange
  • Prednisone


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