Early Noise-Induced Hearing Loss Accelerates Presbycusis Altering Aging Processes in the Cochlea

Fabiola Paciello, Gaetano Paludetti, Claudio Grassi, Anna Rita Fetoni, Anna Pisani, Rolando Rolesi, Diana Troiani, Andrea Viziano, Arturo Moleti, Renata Sisto

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Several studies identified hearing loss as a risk factor for aging-related processes, including neurodegenerative diseases, as dementia and age-related hearing loss (ARHL). Although the association between hearing impairment in midlife and ARHL has been widely documented by epidemiological and experimental studies, the molecular mechanisms underlying this association are not fully understood. In this study, we used an established animal model of ARHL (C57BL/6 mice) to evaluate if early noise-induced hearing loss (NIHL) could affect the onset or progression of age-related cochlear dysfunction. We found that hearing loss can exacerbate ARHL, damaging sensory-neural cochlear epithelium and causing synaptopathy. Moreover, we studied common pathological markers shared between hearing loss and ARHL, demonstrating that noise exposure can worsen/accelerate redox status imbalance [increase of reactive oxygen species (ROS) production, lipid peroxidation, and dysregulation of endogenous antioxidant response] and vascular dysfunction [increased expression of hypoxia-inducible factor-1alpha (HIF-1α) and vascular endothelial growth factor C (VEGFC)] in the cochlea. Unveiling the molecular mechanisms underlying the link between hearing loss and aging processes could be valuable to identify effective therapeutic strategies to limit the effect of environmental risk factors on age-related diseases.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaFrontiers in Aging Neuroscience
Volume14
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • acoustic trauma
  • age-related hearing loss
  • vascular dysfunction
  • hearing loss
  • oxidative stress
  • aging

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