Early Detection of Central Visual Function Decline in Cone-Rod Dystrophy by the Use of Macular Focal Cone Electroretinogram

Angelo Maria Minnella, Benedetto Falsini, Lucia Galli-Resta, Lucia Ziccardi, Antonello Fadda, Giovanni Resta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

PURPOSE. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS. A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 +/- 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 188 of visual field. RESULTS. Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and-in 50% of the cases-fERG loss anticipated acuity loss of several years. CONCLUSIONS. Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
Lingua originaleEnglish
pagine (da-a)6560-6569
Numero di pagine10
RivistaINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume54
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • cone–rod dystrophy, focal ERG, visual acuity

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