Early beneficial effects of drug-eluting stents in vein grafts wane during long term follow-up: A Case-Control Study

Vincenzo Pasceri, Giandomenico Tarsia, Giampaolo Niccoli, Nicola Viceconte, Italo Porto, Antonio Maria Leone, Carlo Trani, Giulio Speciale, Pasquale Lisanti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)


Objectives The aim of the study was to compare outcomes of drug-eluting stents (DES) versus bare-metal stents (BMS) in saphenous vein graft (SVG) interventions in a case-control study with a long-term follow-up. Background Safety and efficacy of DES in SVG interventions are still controversial. Methods We performed a multicenter registry assessing clinical outcomes with DES vs. BMS. We included 311 patients (239 men, age 68 ± 8 years) who underwent percutaneous coronary interventions (PCI) of SVG lesions with DES (n = 138) or BMS (n = 173) with a 2-year follow-up. Results The two groups were similar for age, sex, main risk factors, incidence of diabetes, use of IIb/IIIa antagonists, use of aspiration devices or filters, number of stents, and total stent length. Overall, at 9 months follow-up incidence of major adverse cardiac events (MACE) and target vessel revascularization (TVR) were significantly lower in the DES group compared with the BMS group (10.9% vs. 22.0%, P = 0.014 and 8.7% vs. 19.1% in DES and BMS respectively, P = 0.015), while there was no significant difference in incidence of myocardial infarction (5.1% vs. 5.2%, P = 0.96) or death (2.2% vs. 4%, respectively, P = 0.54). However, at 24-month follow-up incidence of MACE was 29.7% in the DES group and 37.0% in BMS group (P = 0.29); incidence of TVR (23.2% vs. 28.9% P = 0.39), myocardial infarction (9.4% vs. 9.2%), death (7.2% vs. 6.9%) were also similar in the two groups. Conclusions Although DES appear safe, our findings suggest that the early benefit of DES in SVG may rapidly wane during long-term follow-up. Copyright © 2012 Wiley Periodicals, Inc.
Lingua originaleEnglish
pagine (da-a)1112-1117
Numero di pagine6
RivistaCatheterization and Cardiovascular Interventions
Stato di pubblicazionePubblicato - 2012


  • Aged
  • Case-Control Studies
  • Chi-Square Distribution
  • Coronary Artery Bypass
  • Disease-Free Survival
  • Drug-Eluting Stents
  • Female
  • Graft Occlusion, Vascular
  • Humans
  • Incidence
  • Italy
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction
  • Percutaneous Coronary Intervention
  • Propensity Score
  • Prospective Studies
  • Prosthesis Design
  • Registries
  • Risk Factors
  • Saphenous Vein
  • Time Factors
  • Treatment Outcome
  • bypass grafts - coronary (GRFT)
  • percutaneous coronary intervention (PCI)
  • restenosis (RSTN)


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