Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

Federica Wolf; Valentina Trapani

doi:10.1016/j.ceca.2019.102078

Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

Federica Wolf, Valentina Trapani

Risultato della ricerca: Contributo in rivista › Articolo in rivista

8 Citazioni (Scopus)

Abstract

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

Lingua originale	English
pagine (da-a)	102078-N/A
Rivista	Cell Calcium
DOI	https://doi.org/10.1016/j.ceca.2019.102078
Stato di pubblicazione	Pubblicato - 2019

Keywords

Cyclin M
Invasion
Metabolism
Proliferation
Solute carrier
Transient receptor potential melastatin type

Accesso al documento

10.1016/j.ceca.2019.102078

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abstract = "Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.",

keywords = "Cyclin M, Invasion, Metabolism, Proliferation, Solute carrier, Transient receptor potential melastatin type, Cyclin M, Invasion, Metabolism, Proliferation, Solute carrier, Transient receptor potential melastatin type",

author = "Federica Wolf and Valentina Trapani",

year = "2019",

doi = "10.1016/j.ceca.2019.102078",

language = "English",

pages = "102078--N/A",

journal = "Cell Calcium",

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T1 - Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

AU - Wolf, Federica

AU - Trapani, Valentina

PY - 2019

Y1 - 2019

N2 - Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

AB - Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

KW - Cyclin M

KW - Invasion

KW - Metabolism

KW - Proliferation

KW - Solute carrier

KW - Transient receptor potential melastatin type

KW - Cyclin M

KW - Invasion

KW - Metabolism

KW - Proliferation

KW - Solute carrier

KW - Transient receptor potential melastatin type

UR - http://hdl.handle.net/10807/142628

UR - http://www.elsevier-international.com/journals/ceca/

U2 - 10.1016/j.ceca.2019.102078

DO - 10.1016/j.ceca.2019.102078

M3 - Article

SP - 102078-N/A

JO - Cell Calcium

JF - Cell Calcium

SN - 0143-4160

ER -