Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

V. Trapani; F Wolf

doi:10.1016/j.ceca.2019.102078

Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

V. Trapani^*, F Wolf

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

10 Citazioni (Scopus)

Abstract

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

Lingua originale	Inglese
pagine (da-a)	102078-N/A
Rivista	Cell Calcium
Numero di pubblicazione	83
DOI	https://doi.org/10.1016/j.ceca.2019.102078
Stato di pubblicazione	Pubblicato - 2019
Pubblicato esternamente	Sì

All Science Journal Classification (ASJC) codes

Fisiologia
Biologia Molecolare
Biologia Cellulare

Keywords

Cyclin M
Invasion
Metabolism
Proliferation
Solute carrier
Transient receptor potential melastatin type

OSS delle Nazioni Unite

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10.1016/j.ceca.2019.102078

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abstract = "Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.",

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AU - Trapani, V.

AU - Wolf, F

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AB - Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

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KW - Invasion

KW - Metabolism

KW - Proliferation

KW - Solute carrier

KW - Transient receptor potential melastatin type

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KW - Invasion

KW - Metabolism

KW - Proliferation

KW - Solute carrier

KW - Transient receptor potential melastatin type

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Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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