Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

V. Trapani*, F Wolf

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

10 Citazioni (Scopus)

Abstract

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.
Lingua originaleInglese
pagine (da-a)102078-N/A
RivistaCell Calcium
Numero di pubblicazione83
DOI
Stato di pubblicazionePubblicato - 2019
Pubblicato esternamente

All Science Journal Classification (ASJC) codes

  • Fisiologia
  • Biologia Molecolare
  • Biologia Cellulare

Keywords

  • Cyclin M
  • Invasion
  • Metabolism
  • Proliferation
  • Solute carrier
  • Transient receptor potential melastatin type

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