Drug use and upper gastrointestinal complications in children: a case-control study

Nadia Mores, Antonio Chiaretti, Costantino Romagnoli, Giulia Bersani, Alessia De Nisco, Riccardo Riccardi, Francesca Menniti-Ippolito, Roberto Da Cas, Luciano Sagliocca, Giuseppe Traversa, Fernanda Ferrazin, Carmela Santuccio, Loriana Tartaglia, Francesco Trotta, Pasquale Di Pietro, Salvatore Renna, Rossella Rossi, Bianca Domenichini, Stefania Gamba, Francesco TrovatoPier-Angelo Tovo, Manuela Bianciotto, Carmelina Calitri, Clara Gabiano, Irene Raffaldi, Antonio Urbino, Liviana Da Dalt, Valentina Favero, Laura Giordano, Maura Baraldi, Federica Bertuola, Eleonora Lorenzon, Francesca Parata, Giorgio Perilongo, Silvia Vendramin, Monica Frassineti, Anna Maria Calvani, Elena Chiappini, Maurizio De Martino, Claudia Fancelli, Francesco Mannelli, Rachele Mazzantini, Sara Sollai, Elisabetta Venturini, Nicola Pirozzi, Umberto Raucci, Antonino Reale, Rossella Rossi, Vincenzo Tipo, Michele Dinardo, Teresa Pisapia, Annalisa Capuano, Elisabetta Parretta, Concita Rafaniello, Fortunata Fucà, Eleonora Di Rosa

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

27 Citazioni (Scopus)

Abstract

OBJECTIVE: To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. METHODS: This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. RESULTS: 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1-8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs. CONCLUSIONS: NSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.
Lingua originaleEnglish
pagine (da-a)218-221
Numero di pagine4
RivistaArchives of Disease in Childhood
Volume98
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Acetaminophen
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Gastrointestinal Diseases
  • Humans
  • Infant
  • Italy
  • Logistic Models
  • Male
  • Prospective Studies
  • Risk
  • Upper Gastrointestinal Tract

Fingerprint Entra nei temi di ricerca di 'Drug use and upper gastrointestinal complications in children: a case-control study'. Insieme formano una fingerprint unica.

Cita questo