Drug-induced hair colour changes

Francesco Ricci, Clara De Simone, Laura Del Regno, Ketty Peris

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)


Hair colour modifications comprise lightening/graying, darkening, or even a complete hair colour change, which may involve the scalp and/or all body hair. Systemic medications may cause hair loss or hypertrichosis, while hair colour change is an uncommon adverse effect. The rapidly increasing use of new target therapies will make the observation of these side effects more frequent. A clear relationship between drug intake and hair colour modification may be difficult to demonstrate and the underlying mechanisms of hair changes are often unknown. To assess whether a side effect is determined by a specific drug, different algorithms or scores (e.g. Naranjo, Karch, Kramer, and Begaud) have been developed. The knowledge of previous similar reports on drug reactions is a key point of most algorithms, therefore all adverse events should be recognised and reported to the scientific community. Furthermore, even if hair colour change is not a life-threatening side effect, it is of deep concern for patient's quality of life and adherence to treatment. We performed a review of the literature on systemic drugs which may induce changes in hair colour.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEuropean Journal of Dermatology
Stato di pubblicazionePubblicato - 2016


  • drug
  • hair colour changes
  • hair depigmentation
  • hair hyperpigmentation


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