Drug coated balloons and their role in bifurcation coronary angioplasty: appraisal of the current evidence and future directions

Francesco Burzotta, Sudhir Rathore, Shana Tehrani, Deiti Prvulovic, Mario Araya, Thierry Lefèvre, Adrian P Banning, Gianluca Rigatelli, Juan Luis Gutierrez-Chico, Klaus Bonaventura, Bernard Chevalier, Yoshihisa Kinoshita, Jozica Sikic, Fernando Alfonso, Yves Louvard, Goran Stankovic

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Introduction: Coronary Bifurcation lesions are technically more challenging and Bifurcation percutaneous coronary intervention (PCI) remains a challenge with unpredictable and sub-optimal clinical and angiographic results. Drug-Coated Balloons (DCB) are emerging devices in the field of coronary intervention with promising results that may overcome some of drug eluting stents limitations and may have potential advantages in complex bifurcation PCI. Areas covered: We have performed a re-appraisal about the issues with current bifurcation PCI techniques and the use of DCB in the treatment of Bifurcation lesions. Several studies performed utilizing DCB are described and critically appraised. Over the recent years, there have been tremendous developments in the DCB technology, lesion preparation, clinical experience, and clinical data during bifurcation PCI. The current review describes the advances in the DCB technology, pharmacokinetics, role of excipients, and optimization of the technique. Special emphasis in lesion preparation and potential pathway of using DCB in bifurcation PCI is proposed. Expert opinion: Although different proof of concept and pilot studies have shown promising results in treatment of bifurcation lesions with DCB, larger randomized trials and/or international consensus papers are required to enable worldwide translation of this idea to clinical practice.
Lingua originaleEnglish
pagine (da-a)1021-1033
Numero di pagine13
RivistaExpert Review of Medical Devices
Volume17
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • coronary bifurcation lesions
  • Drug coated balloon
  • future directions
  • target lesion revascularization
  • mace
  • outcomes
  • lesion preparation

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