Driving chronicity in rheumatoid arthritis: Perpetuating role of myeloid cells

Stefano Alivernini, Elisa Gremese, Barbara Tolusso, Gianfranco Ferraccioli, M. Kurowska-Stolarska, I. B. Mcinnes

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Acute inflammation is a complex and tightly regulated homeostatic process that includes leucocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair. However, if inflammation is uncontrolled as in chronic diseases such as rheumatoid arthritis (RA), it leads to tissue damage and disability. Synovial tissue inflammation in RA patients is maintained by sustained activation of multiple inflammatory positive-feedback regulatory pathways in a variety of cells, including myeloid cells. In this review, we will highlight recent evidence uncovering biological mechanisms contributing to the aberrant activation of myeloid cells that contributes to perpetuation of inflammation in RA, and discuss emerging data on anti-inflammatory mediators contributing to sustained remission that may inform a novel category of therapeutic targets.
Lingua originaleEnglish
pagine (da-a)13-23
RivistaClinical and Experimental Immunology
Volume193
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • arthritis (including rheumatoid arthritis)
  • cytokines
  • inflammation
  • macrophage

Fingerprint

Entra nei temi di ricerca di 'Driving chronicity in rheumatoid arthritis: Perpetuating role of myeloid cells'. Insieme formano una fingerprint unica.

Cita questo