Dose-dense weekly chemotherapy in advanced ovarian cancer: An updated meta-analysis of randomized controlled trials

Claudia Marchetti, F. De Felice, A. Di Pinto, O. D'Oria, N. Aleksa, A. Musella, I. Palaia, L. Muzii, V. Tombolini, P. Benedetti Panici

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Objective: The use of dose-dense weekly chemotherapy in the management of advanced ovarian cancer (OC) remains controversial. The aim of this meta-analysis was to evaluate the efficacy of dose-dense regimen to improve clinical outcomes in OC patients with the inclusion of new trials. Methods: For this updated meta-analysis, PubMed Medline and Scopus databases and meeting proceedings were searched for eligible studies with the limitation of randomized controlled trials, comparing dose-dense chemotherapy versus standard treatment. Trials were grouped in two types of dose-dense chemotherapy: weekly dose-dense (both paclitaxel and carboplatin weekly administration) and semi-weekly dose-dense (weekly paclitaxel and three weekly carboplatin administration). Data were extracted independently and were analyzed using RevMan statistical software version 5.3 ( Primary end-point was progression-free survival (PFS). Results: Four randomized controlled trials comprising 3698 patients were identified as eligible. Dose-dense chemotherapy had not a significant benefit on PFS (HR 0.92, 95% CI 0.81–1.04, p = 0.20). When the analysis was restricted to both weekly and semi-weekly dose-dense data, a no significant interaction between dose-dense and standard regimen was confirmed (HR 1.01, 95% CI 0.93–1.10 and HR 0.82, 95% CI 0.63–1.08, respectively). Conclusions: In the absence of PFS superiority of dose-dense schedule, three weekly schedule should remain the standard of care for advanced OC.
Lingua originaleEnglish
pagine (da-a)30-34
Numero di pagine5
Stato di pubblicazionePubblicato - 2018


  • Anemia
  • Chemotherapy
  • Dose-dense
  • Ovarian cancer
  • Surgery
  • Survival
  • Toxicity
  • Weekly


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