Donor risk index and organ patient index as predictors of graft survival after liver transplantation

Alfonso Wolfango Avolio, Antonio Gasbarrini, Salvatore Agnes, Massimo Siciliano, Raffaella Barbarino, Erida Nure, Marco Castagneto, Be Annicchiarico

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)

Abstract

In liver transplantation the identification of risk factors and the risk quantification for each single case represent a field of great interest. There are donor-related and recipient-related risk factors. Donor risk index (DRI) was retrospectively calculated in 223 liver transplant cases. We did not include patients with preoperative diagnosis of hepatocarcinoma and retransplants. The cases were stratified into two classes according to the DRI (low risk, DRI<1.7, and high risk, DRI >or= 1.7). A new index, namely the organ patient index (OPI) was calculated adding the Model for End-stage Liver Disease (MELD) score to the DRI. Patients were stratified into two classes according to the OPI (low risk, OPI <or= 2.85, and high risk, OPI>2.85). The cases with low DRI (n=144) showed better survival than the cases with high DRI (n=82; P< .02). The cases with low OPI (n=173) showed better survival than cases with high OPI (n=50; P< .01). The OPI predicted outcomes better than DRI, increasing the gap in the long-term graft survival between the low- and the high-risk class. The inclusion of the MELD in the new index allowed better prediction of graft survival.
Lingua originaleEnglish
pagine (da-a)1899-1902
Numero di pagine4
RivistaTransplantation Proceedings
Volume40
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • Graft Survival
  • Humans
  • Liver Transplantation
  • Patient Selection
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Assessment
  • Tissue Donors

Fingerprint Entra nei temi di ricerca di 'Donor risk index and organ patient index as predictors of graft survival after liver transplantation'. Insieme formano una fingerprint unica.

Cita questo