Abstract
Primary myelofibrosis (PMF) is a rare myeloproliferative neoplasm characterized by clonal
proliferation of mature myeloid lineages derived from stem cells (erythrocytes, leukocytes and
magakaryocytes) with variable megakaryocyte atypia associated with reticulin and / or collagen
bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary
hematopoiesis and abnormal expression of cytokines.
Allogeneic hemopoietic stem cell transplantation (alloHSCT) is currently the only curative approach
for patients with myelofibrosis, and for this reason the number of allografts for this indications have
been growing over the past years.
Unfortunately relapse of myelofibrosis (MF) after an alloHSCT occurs in 10-40% of cases: patients
usually present with a declining donor chimerism, and a reappearance of driver mutations if
present; a bone marrow (BM) biopsy is usually consistent with typical megakaryocyte abnormalities
and stromal fibrosis. Ultimately BM cells exhibit progressive loss of donor chimerism, and the
relapse is therefore of recipient origin. Here we report two allografted MF patients who relapsed in
donor cells
Lingua originale | English |
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pagine (da-a) | 77-78 |
Numero di pagine | 2 |
Rivista | Haematologica |
Stato di pubblicazione | Pubblicato - 2019 |
Keywords
- Donor cell-derived myelofibrosis relapse after allogeneic