Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

Roberto Bergamaschi; Ettore Beghi; Cristina Bosetti; Michela Ponzio; Claudia Santucci; Vito Lepore; Paola Mosconi; U Aguglia; M P Amato; A L Ancona; B Ardito; C Avolio; R Balgera; P Banfi; V Barcella; P Barone; P Bellantonio; A Berardinelli; R Bergamaschi; P Bertora; M Bianchi; P Bramanti; V Brescia Morra; G Brichetto; A M Brioschi; M Buccafusca; S Bucello; V Busillo; B Calchetti; R Cantello; M Capobianco; F Capone; L Capone; D Cargnelutti; M Carrozzi; E Cartechini; G Cavaletti; P Cavalla; M G Celani; R Clerici; M Clerico; E Cocco; P Confalonieri; M G Coniglio; A Conte; F Corea; S Cottone; P Crociani; F D'Andrea; M C Danni; G De Luca; D de Pascalis; M De Riz; F De Robertis; G De Rosa; N De Stefano; M Della Corte; A Di Sapio; R Docimo; M Falcini; N Falcone; S Fermi; E Ferraro; M T Ferrò; M Fortunato; M Foschi; A Gajofatto; A Gallo; P Gallo; M Gatto; P Gazzola; A Giordano; F Granella; M F Grasso; M G Grasso; L M E Grimaldi; P Iaffaldano; D Imperiale; M Inglese; R Iodice; S Leva; V Luezzi; A Lugaresi; G Lus; D Maimone; L Mancinelli; G T Maniscalco; G A Marfia; B Marini; A Marson; N Mascoli; L Massacesi; F Melani; M Merello; G Meucci; Massimiliano Mirabella; S Montepietra; D Nasuelli; P Nicolao; F Passantino; F Patti; M Peresson; I Pesci; C Piantadosi; M L Piras; M Pizzorno; K Plewnia; C Pozzilli; A Protti; R Quatrale; S Realmuto; G Ribizzi; S Rinalduzzi; A Rini; S Romano; M Romeo; M Ronzoni; P Rossi; M Rovaris; G Salemi; G Santangelo; M Santangelo; G Santuccio; P Sarchielli; L Sinisi; P Sola; C Solaro; D Spitaleri; S Strumia; T Tassinari; S Tonietti; C Tortorella; R Totaro; A Tozzo; G Trivelli; M Ulivelli; P Valentino; S Venturi; M Vianello; M Zaffaroni; R Zarbo; Maria Trojano; Mario Alberto Battaglia; Marco Capobianco; Maura Pugliatti; Monica Ulivelli; Paola Mosconi; Claudio Gasperini; Francesco Patti; Maria Pia Amato; Roberto Bergamaschi; Giancarlo Comi

doi:10.1007/s10072-022-06169-7

Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

Roberto Bergamaschi, Ettore Beghi, Cristina Bosetti, Michela Ponzio, Claudia Santucci, Vito Lepore, Paola Mosconi^*, U Aguglia, M P Amato, A L Ancona, B Ardito, C Avolio, R Balgera, P Banfi, V Barcella, P Barone, P Bellantonio, A Berardinelli, R Bergamaschi, P BertoraM Bianchi, P Bramanti, V Brescia Morra, G Brichetto, A M Brioschi, M Buccafusca, S Bucello, V Busillo, B Calchetti, R Cantello, M Capobianco, F Capone, L Capone, D Cargnelutti, M Carrozzi, E Cartechini, G Cavaletti, P Cavalla, M G Celani, R Clerici, M Clerico, E Cocco, P Confalonieri, M G Coniglio, A Conte, F Corea, S Cottone, P Crociani, F D'Andrea, M C Danni, G De Luca, D de Pascalis, M De Riz, F De Robertis, G De Rosa, N De Stefano, M Della Corte, A Di Sapio, R Docimo, M Falcini, N Falcone, S Fermi, E Ferraro, M T Ferrò, M Fortunato, M Foschi, A Gajofatto, A Gallo, P Gallo, M Gatto, P Gazzola, A Giordano, F Granella, M F Grasso, M G Grasso, L M E Grimaldi, P Iaffaldano, D Imperiale, M Inglese, R Iodice, S Leva, V Luezzi, A Lugaresi, G Lus, D Maimone, L Mancinelli, G T Maniscalco, G A Marfia, B Marini, A Marson, N Mascoli, L Massacesi, F Melani, M Merello, G Meucci, Massimiliano Mirabella, S Montepietra, D Nasuelli, P Nicolao, F Passantino, F Patti, M Peresson, I Pesci, C Piantadosi, M L Piras, M Pizzorno, K Plewnia, C Pozzilli, A Protti, R Quatrale, S Realmuto, G Ribizzi, S Rinalduzzi, A Rini, S Romano, M Romeo, M Ronzoni, P Rossi, M Rovaris, G Salemi, G Santangelo, M Santangelo, G Santuccio, P Sarchielli, L Sinisi, P Sola, C Solaro, D Spitaleri, S Strumia, T Tassinari, S Tonietti, C Tortorella, R Totaro, A Tozzo, G Trivelli, M Ulivelli, P Valentino, S Venturi, M Vianello, M Zaffaroni, R Zarbo, Maria Trojano, Mario Alberto Battaglia, Marco Capobianco, Maura Pugliatti, Monica Ulivelli, Paola Mosconi^*, Claudio Gasperini, Francesco Patti, Maria Pia Amato, Roberto Bergamaschi, Giancarlo Comi

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part.Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000-2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing-remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers' characteristics, geographic macro-areas, and Deprivation Index. We computed the odds ratios (OR) for CIS, PP/PR, and SP phenotypes, compared to the RR, using multivariate, multinomial, mixed effects logistic regression models.Results In all 35,243 patients from 106 centers were included. The OR of presenting more advanced MS phenotypes than the RR phenotype at first visit significantly diminished in relation to calendar period. Females were at a significantly lower risk of a PP/PR or SP phenotype. Older age was associated with CIS, PP/PR, and SP. The risk of a longer interval between disease onset and first visit was lower for the CIS phenotype, but higher for PP/PR and SP. The probability of SP at first visit was greater in the South of Italy.Discussion Differences in the phenotype of MS patients first seen in Italian centers can be only partly explained by differences in the centers' characteristics. The demographic and socio-economic characteristics of MS patients seem to be the main determinants of the phenotypes at first referral.

Lingua originale	Inglese
pagine (da-a)	5459-5469
Numero di pagine	11
Rivista	Neurological Sciences
Volume	43
Numero di pubblicazione	Sep
DOI	https://doi.org/10.1007/s10072-022-06169-7
Stato di pubblicazione	Pubblicato - 2022

All Science Journal Classification (ASJC) codes

Dermatologia
Neurologia (clinica)
Psichiatria e Salute Mentale

Keywords

Centers’ characteristics
Italian Multiple Sclerosis Register
Multiple sclerosis phenotypes
Real-world data

Accesso al documento

10.1007/s10072-022-06169-7

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Bergamaschi, R., Beghi, E., Bosetti, C., Ponzio, M., Santucci, C., Lepore, V., Mosconi, P., Aguglia, U., Amato, M. P., Ancona, A. L., Ardito, B., Avolio, C., Balgera, R., Banfi, P., Barcella, V., Barone, P., Bellantonio, P., Berardinelli, A., Bergamaschi, R., ... Comi, G. (2022). Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register. Neurological Sciences, 43(Sep), 5459-5469. https://doi.org/10.1007/s10072-022-06169-7

@article{b37dd46303e04eba9a214bd3488db55e,

title = "Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register",

abstract = "Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part.Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000-2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing-remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers' characteristics, geographic macro-areas, and Deprivation Index. We computed the odds ratios (OR) for CIS, PP/PR, and SP phenotypes, compared to the RR, using multivariate, multinomial, mixed effects logistic regression models.Results In all 35,243 patients from 106 centers were included. The OR of presenting more advanced MS phenotypes than the RR phenotype at first visit significantly diminished in relation to calendar period. Females were at a significantly lower risk of a PP/PR or SP phenotype. Older age was associated with CIS, PP/PR, and SP. The risk of a longer interval between disease onset and first visit was lower for the CIS phenotype, but higher for PP/PR and SP. The probability of SP at first visit was greater in the South of Italy.Discussion Differences in the phenotype of MS patients first seen in Italian centers can be only partly explained by differences in the centers' characteristics. The demographic and socio-economic characteristics of MS patients seem to be the main determinants of the phenotypes at first referral.",

keywords = "Centers{\textquoteright} characteristics, Italian Multiple Sclerosis Register, Multiple sclerosis phenotypes, Real-world data, Centers{\textquoteright} characteristics, Italian Multiple Sclerosis Register, Multiple sclerosis phenotypes, Real-world data",

author = "Roberto Bergamaschi and Ettore Beghi and Cristina Bosetti and Michela Ponzio and Claudia Santucci and Vito Lepore and Paola Mosconi and U Aguglia and Amato, {M P} and Ancona, {A L} and B Ardito and C Avolio and R Balgera and P Banfi and V Barcella and P Barone and P Bellantonio and A Berardinelli and R Bergamaschi and P Bertora and M Bianchi and P Bramanti and Morra, {V Brescia} and G Brichetto and Brioschi, {A M} and M Buccafusca and S Bucello and V Busillo and B Calchetti and R Cantello and M Capobianco and F Capone and L Capone and D Cargnelutti and M Carrozzi and E Cartechini and G Cavaletti and P Cavalla and Celani, {M G} and R Clerici and M Clerico and E Cocco and P Confalonieri and Coniglio, {M G} and A Conte and F Corea and S Cottone and P Crociani and F D'Andrea and Danni, {M C} and {De Luca}, G and {de Pascalis}, D and {De Riz}, M and {De Robertis}, F and {De Rosa}, G and {De Stefano}, N and Corte, {M Della} and {Di Sapio}, A and R Docimo and M Falcini and N Falcone and S Fermi and E Ferraro and Ferr{\`o}, {M T} and M Fortunato and M Foschi and A Gajofatto and A Gallo and P Gallo and M Gatto and P Gazzola and A Giordano and F Granella and Grasso, {M F} and Grasso, {M G} and Grimaldi, {L M E} and P Iaffaldano and D Imperiale and M Inglese and R Iodice and S Leva and V Luezzi and A Lugaresi and G Lus and D Maimone and L Mancinelli and Maniscalco, {G T} and Marfia, {G A} and B Marini and A Marson and N Mascoli and L Massacesi and F Melani and M Merello and G Meucci and Massimiliano Mirabella and S Montepietra and D Nasuelli and P Nicolao and F Passantino and F Patti and M Peresson and I Pesci and C Piantadosi and Piras, {M L} and M Pizzorno and K Plewnia and C Pozzilli and A Protti and R Quatrale and S Realmuto and G Ribizzi and S Rinalduzzi and A Rini and S Romano and M Romeo and M Ronzoni and P Rossi and M Rovaris and G Salemi and G Santangelo and M Santangelo and G Santuccio and P Sarchielli and L Sinisi and P Sola and C Solaro and D Spitaleri and S Strumia and T Tassinari and S Tonietti and C Tortorella and R Totaro and A Tozzo and G Trivelli and M Ulivelli and P Valentino and S Venturi and M Vianello and M Zaffaroni and R Zarbo and Maria Trojano and Battaglia, {Mario Alberto} and Marco Capobianco and Maura Pugliatti and Monica Ulivelli and Paola Mosconi and Claudio Gasperini and Francesco Patti and Amato, {Maria Pia} and Roberto Bergamaschi and Giancarlo Comi",

year = "2022",

doi = "10.1007/s10072-022-06169-7",

language = "English",

volume = "43",

pages = "5459--5469",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia s.r.l.",

number = "Sep",

}

Bergamaschi, R, Beghi, E, Bosetti, C, Ponzio, M, Santucci, C, Lepore, V, Mosconi, P, Aguglia, U, Amato, MP, Ancona, AL, Ardito, B, Avolio, C, Balgera, R, Banfi, P, Barcella, V, Barone, P, Bellantonio, P, Berardinelli, A, Bergamaschi, R, Bertora, P, Bianchi, M, Bramanti, P, Morra, VB, Brichetto, G, Brioschi, AM, Buccafusca, M, Bucello, S, Busillo, V, Calchetti, B, Cantello, R, Capobianco, M, Capone, F, Capone, L, Cargnelutti, D, Carrozzi, M, Cartechini, E, Cavaletti, G, Cavalla, P, Celani, MG, Clerici, R, Clerico, M, Cocco, E, Confalonieri, P, Coniglio, MG, Conte, A, Corea, F, Cottone, S, Crociani, P, D'Andrea, F, Danni, MC, De Luca, G, de Pascalis, D, De Riz, M, De Robertis, F, De Rosa, G, De Stefano, N, Corte, MD, Di Sapio, A, Docimo, R, Falcini, M, Falcone, N, Fermi, S, Ferraro, E, Ferrò, MT, Fortunato, M, Foschi, M, Gajofatto, A, Gallo, A, Gallo, P, Gatto, M, Gazzola, P, Giordano, A, Granella, F, Grasso, MF, Grasso, MG, Grimaldi, LME, Iaffaldano, P, Imperiale, D, Inglese, M, Iodice, R, Leva, S, Luezzi, V, Lugaresi, A, Lus, G, Maimone, D, Mancinelli, L, Maniscalco, GT, Marfia, GA, Marini, B, Marson, A, Mascoli, N, Massacesi, L, Melani, F, Merello, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Nicolao, P, Passantino, F, Patti, F, Peresson, M, Pesci, I, Piantadosi, C, Piras, ML, Pizzorno, M, Plewnia, K, Pozzilli, C, Protti, A, Quatrale, R, Realmuto, S, Ribizzi, G, Rinalduzzi, S, Rini, A, Romano, S, Romeo, M, Ronzoni, M, Rossi, P, Rovaris, M, Salemi, G, Santangelo, G, Santangelo, M, Santuccio, G, Sarchielli, P, Sinisi, L, Sola, P, Solaro, C, Spitaleri, D, Strumia, S, Tassinari, T, Tonietti, S, Tortorella, C, Totaro, R, Tozzo, A, Trivelli, G, Ulivelli, M, Valentino, P, Venturi, S, Vianello, M, Zaffaroni, M, Zarbo, R, Trojano, M, Battaglia, MA, Capobianco, M, Pugliatti, M, Ulivelli, M, Mosconi, P, Gasperini, C, Patti, F, Amato, MP, Bergamaschi, R & Comi, G 2022, 'Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register', Neurological Sciences, vol. 43, n. Sep, pagg. 5459-5469. https://doi.org/10.1007/s10072-022-06169-7

TY - JOUR

T1 - Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

AU - Bergamaschi, Roberto

AU - Beghi, Ettore

AU - Bosetti, Cristina

AU - Ponzio, Michela

AU - Santucci, Claudia

AU - Lepore, Vito

AU - Mosconi, Paola

AU - Aguglia, U

AU - Amato, M P

AU - Ancona, A L

AU - Ardito, B

AU - Avolio, C

AU - Balgera, R

AU - Banfi, P

AU - Barcella, V

AU - Barone, P

AU - Bellantonio, P

AU - Berardinelli, A

AU - Bergamaschi, R

AU - Bertora, P

AU - Bianchi, M

AU - Bramanti, P

AU - Morra, V Brescia

AU - Brichetto, G

AU - Brioschi, A M

AU - Buccafusca, M

AU - Bucello, S

AU - Busillo, V

AU - Calchetti, B

AU - Cantello, R

AU - Capobianco, M

AU - Capone, F

AU - Capone, L

AU - Cargnelutti, D

AU - Carrozzi, M

AU - Cartechini, E

AU - Cavaletti, G

AU - Cavalla, P

AU - Celani, M G

AU - Clerici, R

AU - Clerico, M

AU - Cocco, E

AU - Confalonieri, P

AU - Coniglio, M G

AU - Conte, A

AU - Corea, F

AU - Cottone, S

AU - Crociani, P

AU - D'Andrea, F

AU - Danni, M C

AU - De Luca, G

AU - de Pascalis, D

AU - De Riz, M

AU - De Robertis, F

AU - De Rosa, G

AU - De Stefano, N

AU - Corte, M Della

AU - Di Sapio, A

AU - Docimo, R

AU - Falcini, M

AU - Falcone, N

AU - Fermi, S

AU - Ferraro, E

AU - Ferrò, M T

AU - Fortunato, M

AU - Foschi, M

AU - Gajofatto, A

AU - Gallo, A

AU - Gallo, P

AU - Gatto, M

AU - Gazzola, P

AU - Giordano, A

AU - Granella, F

AU - Grasso, M F

AU - Grasso, M G

AU - Grimaldi, L M E

AU - Iaffaldano, P

AU - Imperiale, D

AU - Inglese, M

AU - Iodice, R

AU - Leva, S

AU - Luezzi, V

AU - Lugaresi, A

AU - Lus, G

AU - Maimone, D

AU - Mancinelli, L

AU - Maniscalco, G T

AU - Marfia, G A

AU - Marini, B

AU - Marson, A

AU - Mascoli, N

AU - Massacesi, L

AU - Melani, F

AU - Merello, M

AU - Meucci, G

AU - Mirabella, Massimiliano

AU - Montepietra, S

AU - Nasuelli, D

AU - Nicolao, P

AU - Passantino, F

AU - Patti, F

AU - Peresson, M

AU - Pesci, I

AU - Piantadosi, C

AU - Piras, M L

AU - Pizzorno, M

AU - Plewnia, K

AU - Pozzilli, C

AU - Protti, A

AU - Quatrale, R

AU - Realmuto, S

AU - Ribizzi, G

AU - Rinalduzzi, S

AU - Rini, A

AU - Romano, S

AU - Romeo, M

AU - Ronzoni, M

AU - Rossi, P

AU - Rovaris, M

AU - Salemi, G

AU - Santangelo, G

AU - Santangelo, M

AU - Santuccio, G

AU - Sarchielli, P

AU - Sinisi, L

AU - Sola, P

AU - Solaro, C

AU - Spitaleri, D

AU - Strumia, S

AU - Tassinari, T

AU - Tonietti, S

AU - Tortorella, C

AU - Totaro, R

AU - Tozzo, A

AU - Trivelli, G

AU - Ulivelli, M

AU - Valentino, P

AU - Venturi, S

AU - Vianello, M

AU - Zaffaroni, M

AU - Zarbo, R

AU - Trojano, Maria

AU - Battaglia, Mario Alberto

AU - Capobianco, Marco

AU - Pugliatti, Maura

AU - Ulivelli, Monica

AU - Mosconi, Paola

AU - Gasperini, Claudio

AU - Patti, Francesco

AU - Amato, Maria Pia

AU - Bergamaschi, Roberto

AU - Comi, Giancarlo

PY - 2022

Y1 - 2022

N2 - Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part.Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000-2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing-remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers' characteristics, geographic macro-areas, and Deprivation Index. We computed the odds ratios (OR) for CIS, PP/PR, and SP phenotypes, compared to the RR, using multivariate, multinomial, mixed effects logistic regression models.Results In all 35,243 patients from 106 centers were included. The OR of presenting more advanced MS phenotypes than the RR phenotype at first visit significantly diminished in relation to calendar period. Females were at a significantly lower risk of a PP/PR or SP phenotype. Older age was associated with CIS, PP/PR, and SP. The risk of a longer interval between disease onset and first visit was lower for the CIS phenotype, but higher for PP/PR and SP. The probability of SP at first visit was greater in the South of Italy.Discussion Differences in the phenotype of MS patients first seen in Italian centers can be only partly explained by differences in the centers' characteristics. The demographic and socio-economic characteristics of MS patients seem to be the main determinants of the phenotypes at first referral.

AB - Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part.Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000-2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing-remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers' characteristics, geographic macro-areas, and Deprivation Index. We computed the odds ratios (OR) for CIS, PP/PR, and SP phenotypes, compared to the RR, using multivariate, multinomial, mixed effects logistic regression models.Results In all 35,243 patients from 106 centers were included. The OR of presenting more advanced MS phenotypes than the RR phenotype at first visit significantly diminished in relation to calendar period. Females were at a significantly lower risk of a PP/PR or SP phenotype. Older age was associated with CIS, PP/PR, and SP. The risk of a longer interval between disease onset and first visit was lower for the CIS phenotype, but higher for PP/PR and SP. The probability of SP at first visit was greater in the South of Italy.Discussion Differences in the phenotype of MS patients first seen in Italian centers can be only partly explained by differences in the centers' characteristics. The demographic and socio-economic characteristics of MS patients seem to be the main determinants of the phenotypes at first referral.

KW - Centers’ characteristics

KW - Italian Multiple Sclerosis Register

KW - Multiple sclerosis phenotypes

KW - Real-world data

KW - Centers’ characteristics

KW - Italian Multiple Sclerosis Register

KW - Multiple sclerosis phenotypes

KW - Real-world data

UR - https://publicatt.unicatt.it/handle/10807/214488

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85147033862&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147033862&origin=inward

U2 - 10.1007/s10072-022-06169-7

DO - 10.1007/s10072-022-06169-7

M3 - Article

SN - 1590-1874

VL - 43

SP - 5459

EP - 5469

JO - Neurological Sciences

JF - Neurological Sciences

IS - Sep

ER -

Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

Abstract

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Keywords

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