DNA Damage in Stem Cells

Ruggero De Maria Marchiano, Ilio Vitale, Gwenola Manic, Guido Kroemer, Lorenzo Galluzzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

109 Citazioni (Scopus)

Abstract

Both embryonic and adult stem cells are endowed with a superior capacity to prevent the accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells, which would be particularly detrimental to the whole organism. Inducible pluripotent stem cells also display a robust DNA damage response, but the stability of their genome is often conditioned by the mutational history of the cell population of origin, which constitutes an obstacle to clinical applications. Cancer stem cells are particularly tolerant to DNA damage and fail to undergo senescence or regulated cell death upon accumulation of genetic lesions. Such a resistance contributes to the genetic drift of evolving tumors as well as to their limited sensitivity to chemo- and radiotherapy. Here, we discuss the pathophysiological and therapeutic implications of the molecular pathways through which stem cells cope with DNA damage.
Lingua originaleEnglish
pagine (da-a)306-319
Numero di pagine14
RivistaMolecular Cell
Volume66
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Adult Stem Cells
  • Animals
  • Cell Biology
  • DNA Damage
  • DNA Repair
  • DNA mismatch repair
  • DNA synthesis
  • Embryonic Stem Cells
  • Genetic Drift
  • Genomic Instability
  • Humans
  • Molecular Biology
  • Mutation
  • Neoplasms
  • Neoplastic Stem Cells
  • Pluripotent Stem Cells
  • Radiation Tolerance
  • autophagy
  • base excision repair
  • homologous recombination
  • non-homologous end joining
  • nucleotide excision repair
  • p53
  • reactive oxygen species
  • regulated cell death translation

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