Abstract
Here we compared the effects of cortistatin and somatostatin on the production of
prostanoids from primary cultures of rat cortical microglia and astrocytes. We
found that both cortistatin and somatostatin do not modify basal PGE(2) release
from cultured astrocytes in 24-h experiments. Somatostatin further enhanced the
increase in PGE(2) release induced by IL-1beta, whereas cortistatin inhibited
such increase. Experiments on microglia showed that somatostatin has no effect on
basal and IL-1beta-stimulated PGE(2) release, whereas cortistatin reduced
baseline prostanoids production and abolished stimulation elicited by IL-1beta.
The latter effect was associated to the inhibition of COX-2 gene over-expression
induced by the cytokine.
Lingua originale | English |
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pagine (da-a) | 78-83 |
Numero di pagine | 6 |
Rivista | Journal of Neuroimmunology |
Volume | 213 |
DOI | |
Stato di pubblicazione | Pubblicato - 2009 |
Keywords
- astrocytes
- cortistatin
- cycloxygenase
- microglia
- prostaglandin E2
- somatostatin