Divergent clonal selection dominates medulloblastoma at recurrence

A. Sorana Morrissy; Livia Garzia; David J. H. Shih; Scott Zuyderduyn; Xi Huang; Patryk Skowron; Marc Remke; Florence M. G. Cavalli; Vijay Ramaswamy; Patricia E. Lindsay; Salomeh Jelveh; Laura K. Donovan; Xin Wang; Betty Luu; Kory Zayne; Yisu Li; Chelsea Mayoh; Nina Thiessen; Eloi Mercier; Karen L. Mungall; Yusanne Ma; Kane Tse; Thomas Zeng; Karey Shumansky; Andrew J. L. Roth; Sohrab Shah; Hamza Farooq; Noriyuki Kijima; Borja L. Holgado; John J. Y. Lee; Stuart Matan-Lithwick; Jessica Liu; Stephen C. Mack; Alex Manno; K. A. Michealraj; Carolina Nor; John Peacock; Lei Qin; Juri Reimand; Adi Rolider; Yuan Y. Thompson; Xiaochong Wu; Trevor Pugh; Adrian Ally; Mikhail Bilenky; Yaron S. N. Butterfield; Rebecca Carlsen; Young Cheng; Eric Chuah; Richard D. Corbett; Noreen Dhalla; An He; Darlene Lee; Haiyan I. Li; William Long; Michael Mayo; Patrick Plettner; Jenny Q. Qian; Jacqueline E. Schein; Angela Tam; Tina Wong; Inanc Birol; Yongjun Zhao; Claudia C. Faria; José Pimentel; Sofia Nunes; Tarek Shalaby; Michael Grotzer; Ian F. Pollack; Ronald L. Hamilton; Xiao-Nan Li; Anne E. Bendel; Daniel W. Fults; Andrew W. Walter; Toshihiro Kumabe; Teiji Tominaga; V. Peter Collins; Yoon-Jae Cho; Caitlin Hoffman; David Lyden; Jeffrey H. Wisoff; James H. Garvin; Duncan S. Stearns; Luca Massimi; Ulrich Schüller; Jaroslav Sterba; Karel Zitterbart; Stephanie Puget; Olivier Ayrault; Sandra E. Dunn; Daniela P. C. Tirapelli; Carlos G. Carlotti; Helen Wheeler; Andrew R. Hallahan; Wendy Ingram; Tobey J. Macdonald; Jeffrey J. Olson; Erwin G. Van Meir; Ji-Yeoun Lee; Kyu-Chang Wang; Seung-Ki Kim; Byung-Kyu Cho; Torsten Pietsch; Gudrun Fleischhack; Stephan Tippelt; Young Shin Ra; Simon Bailey; Janet C. Lindsey; Steven C. Clifford; Charles G. Eberhart; Michael K. Cooper; Roger J. Packer; Maura Massimino; Maria Luisa Garre; Ute Bartels; Uri Tabori; Cynthia E. Hawkins; Peter Dirks; Eric Bouffet; James T. Rutka; Robert J. Wechsler-Reya; William A. Weiss; Lara S. Collier; Adam J. Dupuy; Andrey Korshunov; David T. W. Jones; Marcel Kool; Paul A. Northcott; Stefan M. Pfister; David A. Largaespada; Andrew J. Mungall; Richard A. Moore; Nada Jabado; Gary D. Bader; Steven J. M. Jones; David Malkin; Marco A. Marra; Michael D. Taylor

doi:10.1038/nature16478

Divergent clonal selection dominates medulloblastoma at recurrence

A. Sorana Morrissy, Livia Garzia, David J. H. Shih, Scott Zuyderduyn, Xi Huang, Patryk Skowron, Marc Remke, Florence M. G. Cavalli, Vijay Ramaswamy, Patricia E. Lindsay, Salomeh Jelveh, Laura K. Donovan, Xin Wang, Betty Luu, Kory Zayne, Yisu Li, Chelsea Mayoh, Nina Thiessen, Eloi Mercier, Karen L. MungallYusanne Ma, Kane Tse, Thomas Zeng, Karey Shumansky, Andrew J. L. Roth, Sohrab Shah, Hamza Farooq, Noriyuki Kijima, Borja L. Holgado, John J. Y. Lee, Stuart Matan-Lithwick, Jessica Liu, Stephen C. Mack, Alex Manno, K. A. Michealraj, Carolina Nor, John Peacock, Lei Qin, Juri Reimand, Adi Rolider, Yuan Y. Thompson, Xiaochong Wu, Trevor Pugh, Adrian Ally, Mikhail Bilenky, Yaron S. N. Butterfield, Rebecca Carlsen, Young Cheng, Eric Chuah, Richard D. Corbett, Noreen Dhalla, An He, Darlene Lee, Haiyan I. Li, William Long, Michael Mayo, Patrick Plettner, Jenny Q. Qian, Jacqueline E. Schein, Angela Tam, Tina Wong, Inanc Birol, Yongjun Zhao, Claudia C. Faria, José Pimentel, Sofia Nunes, Tarek Shalaby, Michael Grotzer, Ian F. Pollack, Ronald L. Hamilton, Xiao-Nan Li, Anne E. Bendel, Daniel W. Fults, Andrew W. Walter, Toshihiro Kumabe, Teiji Tominaga, V. Peter Collins, Yoon-Jae Cho, Caitlin Hoffman, David Lyden, Jeffrey H. Wisoff, James H. Garvin, Duncan S. Stearns, Luca Massimi, Ulrich Schüller, Jaroslav Sterba, Karel Zitterbart, Stephanie Puget, Olivier Ayrault, Sandra E. Dunn, Daniela P. C. Tirapelli, Carlos G. Carlotti, Helen Wheeler, Andrew R. Hallahan, Wendy Ingram, Tobey J. Macdonald, Jeffrey J. Olson, Erwin G. Van Meir, Ji-Yeoun Lee, Kyu-Chang Wang, Seung-Ki Kim, Byung-Kyu Cho, Torsten Pietsch, Gudrun Fleischhack, Stephan Tippelt, Young Shin Ra, Simon Bailey, Janet C. Lindsey, Steven C. Clifford, Charles G. Eberhart, Michael K. Cooper, Roger J. Packer, Maura Massimino, Maria Luisa Garre, Ute Bartels, Uri Tabori, Cynthia E. Hawkins, Peter Dirks, Eric Bouffet, James T. Rutka, Robert J. Wechsler-Reya, William A. Weiss, Lara S. Collier, Adam J. Dupuy, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Stefan M. Pfister, David A. Largaespada, Andrew J. Mungall, Richard A. Moore, Nada Jabado, Gary D. Bader, Steven J. M. Jones, David Malkin, Marco A. Marra, Michael D. Taylor

Risultato della ricerca: Contributo in rivista › Articolo in rivista

173 Citazioni (Scopus)

Abstract

The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.

Lingua originale	English
pagine (da-a)	351-357
Numero di pagine	7
Rivista	Nature
Volume	529
DOI	https://doi.org/10.1038/nature16478
Stato di pubblicazione	Pubblicato - 2016

Keywords

Animals
Cerebellar Neoplasms
Clone Cells
Craniospinal Irradiation
DNA Mutational Analysis
Disease Models, Animal
Drosophila melanogaster
Female
Genome, Human
Humans
Male
Medulloblastoma
Mice
Molecular Targeted Therapy
Multidisciplinary
Neoplasm Recurrence, Local
Radiotherapy, Image-Guided
Selection, Genetic
Signal Transduction
Xenograft Model Antitumor Assays

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Morrissy, A. S., Garzia, L., Shih, D. J. H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M. G., Ramaswamy, V., Lindsay, P. E., Jelveh, S., Donovan, L. K., Wang, X., Luu, B., Zayne, K., Li, Y., Mayoh, C., Thiessen, N., Mercier, E., ... Taylor, M. D. (2016). Divergent clonal selection dominates medulloblastoma at recurrence. Nature, 529, 351-357. https://doi.org/10.1038/nature16478

@article{8036deeb32004361b3650d2061280ea9,

title = "Divergent clonal selection dominates medulloblastoma at recurrence",

abstract = "The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.",

keywords = "Animals, Cerebellar Neoplasms, Clone Cells, Craniospinal Irradiation, DNA Mutational Analysis, Disease Models, Animal, Drosophila melanogaster, Female, Genome, Human, Humans, Male, Medulloblastoma, Mice, Molecular Targeted Therapy, Multidisciplinary, Neoplasm Recurrence, Local, Radiotherapy, Image-Guided, Selection, Genetic, Signal Transduction, Xenograft Model Antitumor Assays, Animals, Cerebellar Neoplasms, Clone Cells, Craniospinal Irradiation, DNA Mutational Analysis, Disease Models, Animal, Drosophila melanogaster, Female, Genome, Human, Humans, Male, Medulloblastoma, Mice, Molecular Targeted Therapy, Multidisciplinary, Neoplasm Recurrence, Local, Radiotherapy, Image-Guided, Selection, Genetic, Signal Transduction, Xenograft Model Antitumor Assays",

author = "Morrissy, {A. Sorana} and Livia Garzia and Shih, {David J. H.} and Scott Zuyderduyn and Xi Huang and Patryk Skowron and Marc Remke and Cavalli, {Florence M. G.} and Vijay Ramaswamy and Lindsay, {Patricia E.} and Salomeh Jelveh and Donovan, {Laura K.} and Xin Wang and Betty Luu and Kory Zayne and Yisu Li and Chelsea Mayoh and Nina Thiessen and Eloi Mercier and Mungall, {Karen L.} and Yusanne Ma and Kane Tse and Thomas Zeng and Karey Shumansky and Roth, {Andrew J. L.} and Sohrab Shah and Hamza Farooq and Noriyuki Kijima and Holgado, {Borja L.} and Lee, {John J. Y.} and Stuart Matan-Lithwick and Jessica Liu and Mack, {Stephen C.} and Alex Manno and Michealraj, {K. A.} and Carolina Nor and John Peacock and Lei Qin and Juri Reimand and Adi Rolider and Thompson, {Yuan Y.} and Xiaochong Wu and Trevor Pugh and Adrian Ally and Mikhail Bilenky and Butterfield, {Yaron S. N.} and Rebecca Carlsen and Young Cheng and Eric Chuah and Corbett, {Richard D.} and Noreen Dhalla and An He and Darlene Lee and Li, {Haiyan I.} and William Long and Michael Mayo and Patrick Plettner and Qian, {Jenny Q.} and Schein, {Jacqueline E.} and Angela Tam and Tina Wong and Inanc Birol and Yongjun Zhao and Faria, {Claudia C.} and Jos{\'e} Pimentel and Sofia Nunes and Tarek Shalaby and Michael Grotzer and Pollack, {Ian F.} and Hamilton, {Ronald L.} and Xiao-Nan Li and Bendel, {Anne E.} and Fults, {Daniel W.} and Walter, {Andrew W.} and Toshihiro Kumabe and Teiji Tominaga and Collins, {V. Peter} and Yoon-Jae Cho and Caitlin Hoffman and David Lyden and Wisoff, {Jeffrey H.} and Garvin, {James H.} and Stearns, {Duncan S.} and Luca Massimi and Ulrich Sch{\"u}ller and Jaroslav Sterba and Karel Zitterbart and Stephanie Puget and Olivier Ayrault and Dunn, {Sandra E.} and Tirapelli, {Daniela P. C.} and Carlotti, {Carlos G.} and Helen Wheeler and Hallahan, {Andrew R.} and Wendy Ingram and Macdonald, {Tobey J.} and Olson, {Jeffrey J.} and {Van Meir}, {Erwin G.} and Ji-Yeoun Lee and Kyu-Chang Wang and Seung-Ki Kim and Byung-Kyu Cho and Torsten Pietsch and Gudrun Fleischhack and Stephan Tippelt and Ra, {Young Shin} and Simon Bailey and Lindsey, {Janet C.} and Clifford, {Steven C.} and Eberhart, {Charles G.} and Cooper, {Michael K.} and Packer, {Roger J.} and Maura Massimino and Garre, {Maria Luisa} and Ute Bartels and Uri Tabori and Hawkins, {Cynthia E.} and Peter Dirks and Eric Bouffet and Rutka, {James T.} and Wechsler-Reya, {Robert J.} and Weiss, {William A.} and Collier, {Lara S.} and Dupuy, {Adam J.} and Andrey Korshunov and Jones, {David T. W.} and Marcel Kool and Northcott, {Paul A.} and Pfister, {Stefan M.} and Largaespada, {David A.} and Mungall, {Andrew J.} and Moore, {Richard A.} and Nada Jabado and Bader, {Gary D.} and Jones, {Steven J. M.} and David Malkin and Marra, {Marco A.} and Taylor, {Michael D.}",

year = "2016",

doi = "10.1038/nature16478",

language = "English",

volume = "529",

pages = "351--357",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

}

Morrissy, AS, Garzia, L, Shih, DJH, Zuyderduyn, S, Huang, X, Skowron, P, Remke, M, Cavalli, FMG, Ramaswamy, V, Lindsay, PE, Jelveh, S, Donovan, LK, Wang, X, Luu, B, Zayne, K, Li, Y, Mayoh, C, Thiessen, N, Mercier, E, Mungall, KL, Ma, Y, Tse, K, Zeng, T, Shumansky, K, Roth, AJL, Shah, S, Farooq, H, Kijima, N, Holgado, BL, Lee, JJY, Matan-Lithwick, S, Liu, J, Mack, SC, Manno, A, Michealraj, KA, Nor, C, Peacock, J, Qin, L, Reimand, J, Rolider, A, Thompson, YY, Wu, X, Pugh, T, Ally, A, Bilenky, M, Butterfield, YSN, Carlsen, R, Cheng, Y, Chuah, E, Corbett, RD, Dhalla, N, He, A, Lee, D, Li, HI, Long, W, Mayo, M, Plettner, P, Qian, JQ, Schein, JE, Tam, A, Wong, T, Birol, I, Zhao, Y, Faria, CC, Pimentel, J, Nunes, S, Shalaby, T, Grotzer, M, Pollack, IF, Hamilton, RL, Li, X-N, Bendel, AE, Fults, DW, Walter, AW, Kumabe, T, Tominaga, T, Collins, VP, Cho, Y-J, Hoffman, C, Lyden, D, Wisoff, JH, Garvin, JH, Stearns, DS, Massimi, L, Schüller, U, Sterba, J, Zitterbart, K, Puget, S, Ayrault, O, Dunn, SE, Tirapelli, DPC, Carlotti, CG, Wheeler, H, Hallahan, AR, Ingram, W, Macdonald, TJ, Olson, JJ, Van Meir, EG, Lee, J-Y, Wang, K-C, Kim, S-K, Cho, B-K, Pietsch, T, Fleischhack, G, Tippelt, S, Ra, YS, Bailey, S, Lindsey, JC, Clifford, SC, Eberhart, CG, Cooper, MK, Packer, RJ, Massimino, M, Garre, ML, Bartels, U, Tabori, U, Hawkins, CE, Dirks, P, Bouffet, E, Rutka, JT, Wechsler-Reya, RJ, Weiss, WA, Collier, LS, Dupuy, AJ, Korshunov, A, Jones, DTW, Kool, M, Northcott, PA, Pfister, SM, Largaespada, DA, Mungall, AJ, Moore, RA, Jabado, N, Bader, GD, Jones, SJM, Malkin, D, Marra, MA & Taylor, MD 2016, 'Divergent clonal selection dominates medulloblastoma at recurrence', Nature, vol. 529, pagg. 351-357. https://doi.org/10.1038/nature16478

TY - JOUR

T1 - Divergent clonal selection dominates medulloblastoma at recurrence

AU - Morrissy, A. Sorana

AU - Garzia, Livia

AU - Shih, David J. H.

AU - Zuyderduyn, Scott

AU - Huang, Xi

AU - Skowron, Patryk

AU - Remke, Marc

AU - Cavalli, Florence M. G.

AU - Ramaswamy, Vijay

AU - Lindsay, Patricia E.

AU - Jelveh, Salomeh

AU - Donovan, Laura K.

AU - Wang, Xin

AU - Luu, Betty

AU - Zayne, Kory

AU - Li, Yisu

AU - Mayoh, Chelsea

AU - Thiessen, Nina

AU - Mercier, Eloi

AU - Mungall, Karen L.

AU - Ma, Yusanne

AU - Tse, Kane

AU - Zeng, Thomas

AU - Shumansky, Karey

AU - Roth, Andrew J. L.

AU - Shah, Sohrab

AU - Farooq, Hamza

AU - Kijima, Noriyuki

AU - Holgado, Borja L.

AU - Lee, John J. Y.

AU - Matan-Lithwick, Stuart

AU - Liu, Jessica

AU - Mack, Stephen C.

AU - Manno, Alex

AU - Michealraj, K. A.

AU - Nor, Carolina

AU - Peacock, John

AU - Qin, Lei

AU - Reimand, Juri

AU - Rolider, Adi

AU - Thompson, Yuan Y.

AU - Wu, Xiaochong

AU - Pugh, Trevor

AU - Ally, Adrian

AU - Bilenky, Mikhail

AU - Butterfield, Yaron S. N.

AU - Carlsen, Rebecca

AU - Cheng, Young

AU - Chuah, Eric

AU - Corbett, Richard D.

AU - Dhalla, Noreen

AU - He, An

AU - Lee, Darlene

AU - Li, Haiyan I.

AU - Long, William

AU - Mayo, Michael

AU - Plettner, Patrick

AU - Qian, Jenny Q.

AU - Schein, Jacqueline E.

AU - Tam, Angela

AU - Wong, Tina

AU - Birol, Inanc

AU - Zhao, Yongjun

AU - Faria, Claudia C.

AU - Pimentel, José

AU - Nunes, Sofia

AU - Shalaby, Tarek

AU - Grotzer, Michael

AU - Pollack, Ian F.

AU - Hamilton, Ronald L.

AU - Li, Xiao-Nan

AU - Bendel, Anne E.

AU - Fults, Daniel W.

AU - Walter, Andrew W.

AU - Kumabe, Toshihiro

AU - Tominaga, Teiji

AU - Collins, V. Peter

AU - Cho, Yoon-Jae

AU - Hoffman, Caitlin

AU - Lyden, David

AU - Wisoff, Jeffrey H.

AU - Garvin, James H.

AU - Stearns, Duncan S.

AU - Massimi, Luca

AU - Schüller, Ulrich

AU - Sterba, Jaroslav

AU - Zitterbart, Karel

AU - Puget, Stephanie

AU - Ayrault, Olivier

AU - Dunn, Sandra E.

AU - Tirapelli, Daniela P. C.

AU - Carlotti, Carlos G.

AU - Wheeler, Helen

AU - Hallahan, Andrew R.

AU - Ingram, Wendy

AU - Macdonald, Tobey J.

AU - Olson, Jeffrey J.

AU - Van Meir, Erwin G.

AU - Lee, Ji-Yeoun

AU - Wang, Kyu-Chang

AU - Kim, Seung-Ki

AU - Cho, Byung-Kyu

AU - Pietsch, Torsten

AU - Fleischhack, Gudrun

AU - Tippelt, Stephan

AU - Ra, Young Shin

AU - Bailey, Simon

AU - Lindsey, Janet C.

AU - Clifford, Steven C.

AU - Eberhart, Charles G.

AU - Cooper, Michael K.

AU - Packer, Roger J.

AU - Massimino, Maura

AU - Garre, Maria Luisa

AU - Bartels, Ute

AU - Tabori, Uri

AU - Hawkins, Cynthia E.

AU - Dirks, Peter

AU - Bouffet, Eric

AU - Rutka, James T.

AU - Wechsler-Reya, Robert J.

AU - Weiss, William A.

AU - Collier, Lara S.

AU - Dupuy, Adam J.

AU - Korshunov, Andrey

AU - Jones, David T. W.

AU - Kool, Marcel

AU - Northcott, Paul A.

AU - Pfister, Stefan M.

AU - Largaespada, David A.

AU - Mungall, Andrew J.

AU - Moore, Richard A.

AU - Jabado, Nada

AU - Bader, Gary D.

AU - Jones, Steven J. M.

AU - Malkin, David

AU - Marra, Marco A.

AU - Taylor, Michael D.

PY - 2016

Y1 - 2016

N2 - The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.

AB - The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.

KW - Animals

KW - Cerebellar Neoplasms

KW - Clone Cells

KW - Craniospinal Irradiation

KW - DNA Mutational Analysis

KW - Disease Models, Animal

KW - Drosophila melanogaster

KW - Female

KW - Genome, Human

KW - Humans

KW - Male

KW - Medulloblastoma

KW - Mice

KW - Molecular Targeted Therapy

KW - Multidisciplinary

KW - Neoplasm Recurrence, Local

KW - Radiotherapy, Image-Guided

KW - Selection, Genetic

KW - Signal Transduction

KW - Xenograft Model Antitumor Assays

KW - Animals

KW - Cerebellar Neoplasms

KW - Clone Cells

KW - Craniospinal Irradiation

KW - DNA Mutational Analysis

KW - Disease Models, Animal

KW - Drosophila melanogaster

KW - Female

KW - Genome, Human

KW - Humans

KW - Male

KW - Medulloblastoma

KW - Mice

KW - Molecular Targeted Therapy

KW - Multidisciplinary

KW - Neoplasm Recurrence, Local

KW - Radiotherapy, Image-Guided

KW - Selection, Genetic

KW - Signal Transduction

KW - Xenograft Model Antitumor Assays

UR - http://hdl.handle.net/10807/124199

UR - http://www.nature.com/nature/index.html

U2 - 10.1038/nature16478

DO - 10.1038/nature16478

M3 - Article

SN - 0028-0836

VL - 529

SP - 351

EP - 357

JO - Nature

JF - Nature

ER -

Divergent clonal selection dominates medulloblastoma at recurrence

Abstract

Keywords

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