Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits

Geltrude Mingrone, Av Greco, A Ciardiello, S Passo, M. Nazzro Porro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

A direct cytotoxic effect of azelaic acid on melanocytes of human melanoma has been demonstrated. In view of a possible future therapeutic employment of this drug in the treatment of primary ocular melanoma, we investigated the route of choice of azelaic acid administration in rabbits. Our results evidenced a suden and direct blood absorption of topically (by retrobulbar injection) administered azelaic acid. This is in agreement with the high water solubility of azelaic acid sodium salt. These preliminary reports indicate that the elective route of azelaic administration in primitive eye melanoma is intravenously by continuous infusion.
Lingua originaleEnglish
pagine (da-a)85-88
Numero di pagine4
RivistaExperimental Pathology
Volume25
Stato di pubblicazionePubblicato - 1984

Keywords

  • Animals
  • Antineoplastic Agents
  • Aqueous Humor
  • Dicarboxylic Acids
  • Eye
  • Eye Neoplasms
  • Male
  • Melanoma
  • Rabbits
  • Tissue Distribution
  • Vitreous Body

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