Distinct lymphocytes subsets in IgM-related neuropathy: clinical-immunological correlations

Mario Sabatelli, Valentina Damato, Raffaele Iorio, Alessandra Del Grande, Giulia Bisogni, Domenico Plantone, Alessandro Marti, Giovanni Frisullo, Angela Romano, Paolo Maria Rossini, Marco Luigetti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

IgM-related neuropathy generally presents as a late-onset demyelinating polyneuropathy with predominant sensory loss and ataxia. However, we recently reported the clinical, neurophysiological and pathological findings from our cohort and identified in about a third of patients an atypical phenotype. We analyzed by flow cytometry the different lymphocytes subsets in the peripheral blood of patients affected by IgM-related neuropathy, chronic inflammatory demyelinating polyneuropathy (CIDP), monoclonal gammopathy of undetermined significance and healthy subjects, to investigate whether different immunological patterns may differentiate the classical phenotype from atypical forms. IFN-gamma producing CD4+ and CD8+ T lymphocytes, as well as CD4+ and CD8+ T cells expressing T-bet (T-helper type 1, Th1) were increased in CIDP patients. The percentage of circulating CD4+ and CD8+ T cells producing IL-10 as well as the percentage of CD19+ cells expressing Blimp-1 were higher in patients with IgM-neuropathy. We did not find any significant differences in the different lymphocytes subsets in the IgM-related neuropathy between patients with classical and atypical phenotype. Th1 cells are increased in CIDP patients while a T helper type 2-phenotype seems to prevail in patients with IgM-neuropathy. Further studies involving a larger patient population are needed to evaluate if different lymphocytes subset may be involved in different clinical phenotypes of IgM-related neuropathy.
Lingua originaleEnglish
pagine (da-a)303-308
Numero di pagine6
RivistaNeurological Sciences
Volume36
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Anti-MAG
  • Clinical phenotype
  • Cytokine
  • IgM-related neuropathy
  • Immunology
  • Neuroscience

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