Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

S Corrao; C Argano; G Natoli; A Nobili; GR Corazza; PM Mannucci; F Perticone; D Prisco; E Silvestri; G Emmi; A Bettiol; C Caterina; G Biolo; M Zanetti; M Guadagni; M Zaccari; M Chiuch; M Zaccari; M Vanoli; G Grignani; EA Pulixi; M Bernardi; SL Bassi; L Santi; G Zaccherini; G Lupattelli; E Mannarino; V Bianconi; F Paciullo; R Alcidi; R Nuti; R Valenti; M Ruvio; S Cappelli; A Palazzuoli; D Girelli; F Busti; G Marchi; M Barbagallo; L Dominguez; F Cocita; V Beneduce; L Plances; S Corrao; G Natoli; S Mularo; M Raspanti; F Cavallaro; M Zoli; I Lazzari; M Brunori; E Fabbri; D Magalotti; R Arno; FL Pasini; PL Capecchi; G Palasciano; ME Modeo; C Di Gennaro; MD Cappellini; D Maira; V Di Stefano; G Fabio; S Seghezzi; M Mancarella; MM De Amicis; G De Luca; N Scaramellini; M Cesari; PD Rossi; S Damanti; M Clerici; F Conti; G Bonini; BB Ottolini; A Di Sabatino; E Miceli; MV Lenti; M Pisati; CC Dominioni; G Murialdo; A Marra; F Cattaneo; R Pontremoli; V Beccati; G Nobili; MB Secchi; D Ghelfi; L Anastasio; L Sofia; M Carbone; L Anastasio; L Sofia; M Carbone; F Cipollone; MT Guagnano; E Valeriani; I Rossi; G Mancuso; D Calipari; M Bartone; G Delitala; M Berria; C Pes; A Delitala; M Muscaritoli; A Molfino; E Petrillo; G Zuccala; G D'Aurizio; G Romanelli; A Marengoni; A Zucchelli; F Manzoni; A Volpini; A Picardi; UV Gentilucci; P Gallo; C Dell'Unto; G Annoni; M Corsi; G Bellelli; S Zazzetta; P Mazzola; H Szabo; A Bonfanti; F Arturi; E Succurro; M Rubino; B Tassone; G Sesti; MG Serra; MA Bleve; L Gasbarrone; MR Sajeva; A Brucato; S Ghidoni; F Fabris; I Bertozzi; G Bogoni; MV Rabuini; E Cosi; P Scarinzi; A Amabile; E Omenetto; T Prandini; R Manfredini; F Fabbian; B Boari; A De Giorgi; R Tiseo; R De Giorgio; G Paolisso; MR Rizzo; C Borghi; E Strocchi; E Ianniello; M Soldati; C Sabba; FS Vella; P Suppressa; P Agosti; A Schilardi; F Loparco; GM De Vincenzo; A Comitangelo; E Amoruso; L Fenoglio; A Falcetta; C Bracco; AL Fracanzani; S Fargion; S Tiraboschi; A Cespiati; G Oberti; G Sigon; F Peyvandi; R Rossio; B Ferrari; G Colombo; V Monzani; V Savojardo; C Folli; G Ceriani; F Salerno; G Pallini; F Dallegri; L Ottonello; L Liberale; L Caserza; K Salam; NL Liberato; T Tognin; GB Bianchi; S Giaquinto; F Purrello; A Di Pino; S Piro; R Rozzini; L Falanga; E Spazzini; C Ferrandina; G Montrucchio; P Petitti; P Peasso; E Favale; C Poletto; R Salmi; P Gaudenzi; F Violi; L Perri; R Landolfi; Massimo Montalto; A Mirijello; L Guasti; L Castiglioni; A Maresca; A Squizzato; L Campiotti; A Grossi; M Bertolotti; C Mussi; G Lancellotti; MV Libbra; G Dondi; E Pellegrini; L Carulli; M Galassi; Y Grassi; F Perticone; M Perticone; R Battaglia; M FIlice; R Maio; V Stanghellini; E Ruggeri; S del Vecchio; A Salvi; R Leonardi; G Damiani; W Capeci; A Gabrielli; M Mattioli; GP Martino; L Biondi; P Pettinari; R Ghio; A Dal Col; S Minisola; L Colangelo; M Cilli; G Labbadia; A Afeltra; B Marigliano; ME Pipita; P Castellino; L Zanoli; S Pignataro; A Gennaro; J Blanco; V Saracco; M Fogliati; C Bussolino; F Mete; M Gino; A Cittadini; C Vigorito; M Arcopinto; A Salzano; E Bobbio; AM Marra; D Sirico; G Moreo; F Gasparini; S Prolo; G Pina; A Ballestrero; F Ferrando; S Berra; S Dassi; MC Nava; B Graziella; S Baldassarre; S Fragapani; G Gruden; G Galanti; G Mascherini; C Petri; L Stefani; M Girino; V Piccinelli; F Nasso; V Gioffre; M Pasquale; G Scattolin; S Martinelli; M Turrin; L Sechi; C Catena; G Colussi; N Passariello; L Rinaldi; F Berti; G Famularo; P Tarsitani; R Castello; M Pasino; GP Ceda; MG Maggio; S Morganti; A Artoni; S Del Giacco; D Firinu; F Losa; G Paoletti; G Costanzo; G Montalto; A Licata; V Malerba; FA Montalto; A Lasco; G Basile; A Catalano; L Malatino; B Stancanelli; V Terranova; S Di Marca; R Di Quattro; L La Malfa; R Caruso; P Mecocci; C Ruggiero; V Boccardi; T Meschi; F Lauretani; A Ticinesi; A Nouvenne; P Minuz; L Fondrieschi; M Pirisi; GP Fra; D Sola; M Porta; P Riva; R Quadri; E Larovere; M Novelli; G Scanzi; C Mengoli; S Provini; L Ricevuti; E Simeone; R Scurti; F Tolloso; R Tarquini; A Valoriani; S Dolenti; G Vannini; A Tedeschi; L Trotta; R Volpi; P Bocchi; A Vignali; S Harari; C Lonati; M Cattaneo; RD Nieves; MM Alberto; AR Pedro; LP Vanessa; T Lara; CV Xavier; F Francesc; DM Jesus; BT Esperanza; DCB Esther; SP Maria; M Romero; PL Blanca; LGC Cristina; VGM Victoria; L Saez; J Bosco; SB Susana; AG Marta; GB Concepcion; FM Antonio; MG Hernandez; MP Borrego; PC Raquel; PR Florencia; GO Beatriz; CG Sara; GCC Alfonso; PM Marta; RC Alberto; AA Antonio; GG Montserrat; BRM Angel; MJ Manuel; NV Ignacio; AS Lucia; L Alfonso; RB David; VI Iniguez; RP Monica

doi:10.1016/j.ejim.2018.04.012

Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

S Corrao^*, C Argano, G Natoli, A Nobili, GR Corazza, PM Mannucci, F Perticone, D Prisco, E Silvestri, G Emmi, A Bettiol, C Caterina, G Biolo, M Zanetti, M Guadagni, M Zaccari, M Chiuch, M Zaccari, M Vanoli, G GrignaniEA Pulixi, M Bernardi, SL Bassi, L Santi, G Zaccherini, G Lupattelli, E Mannarino, V Bianconi, F Paciullo, R Alcidi, R Nuti, R Valenti, M Ruvio, S Cappelli, A Palazzuoli, D Girelli, F Busti, G Marchi, M Barbagallo, L Dominguez, F Cocita, V Beneduce, L Plances, S Corrao^*, G Natoli, S Mularo, M Raspanti, F Cavallaro, M Zoli, I Lazzari, M Brunori, E Fabbri, D Magalotti, R Arno, FL Pasini, PL Capecchi, G Palasciano, ME Modeo, C Di Gennaro, MD Cappellini, D Maira, V Di Stefano, G Fabio, S Seghezzi, M Mancarella, MM De Amicis, G De Luca, N Scaramellini, M Cesari, PD Rossi, S Damanti, M Clerici, F Conti, G Bonini, BB Ottolini, A Di Sabatino, E Miceli, MV Lenti, M Pisati, CC Dominioni, G Murialdo, A Marra, F Cattaneo, R Pontremoli, V Beccati, G Nobili, MB Secchi, D Ghelfi, L Anastasio, L Sofia, M Carbone, L Anastasio, L Sofia, M Carbone, F Cipollone, MT Guagnano, E Valeriani, I Rossi, G Mancuso, D Calipari, M Bartone, G Delitala, M Berria, C Pes, A Delitala, M Muscaritoli, A Molfino, E Petrillo, G Zuccala, G D'Aurizio, G Romanelli, A Marengoni, A Zucchelli, F Manzoni, A Volpini, A Picardi, UV Gentilucci, P Gallo, C Dell'Unto, G Annoni, M Corsi, G Bellelli, S Zazzetta, P Mazzola, H Szabo, A Bonfanti, F Arturi, E Succurro, M Rubino, B Tassone, G Sesti, MG Serra, MA Bleve, L Gasbarrone, MR Sajeva, A Brucato, S Ghidoni, F Fabris, I Bertozzi, G Bogoni, MV Rabuini, E Cosi, P Scarinzi, A Amabile, E Omenetto, T Prandini, R Manfredini, F Fabbian, B Boari, A De Giorgi, R Tiseo, R De Giorgio, G Paolisso, MR Rizzo, C Borghi, E Strocchi, E Ianniello, M Soldati, C Sabba, FS Vella, P Suppressa, P Agosti, A Schilardi, F Loparco, GM De Vincenzo, A Comitangelo, E Amoruso, L Fenoglio, A Falcetta, C Bracco, AL Fracanzani, S Fargion, S Tiraboschi, A Cespiati, G Oberti, G Sigon, F Peyvandi, R Rossio, B Ferrari, G Colombo, V Monzani, V Savojardo, C Folli, G Ceriani, F Salerno, G Pallini, F Dallegri, L Ottonello, L Liberale, L Caserza, K Salam, NL Liberato, T Tognin, GB Bianchi, S Giaquinto, F Purrello, A Di Pino, S Piro, R Rozzini, L Falanga, E Spazzini, C Ferrandina, G Montrucchio, P Petitti, P Peasso, E Favale, C Poletto, R Salmi, P Gaudenzi, F Violi, L Perri, R Landolfi, Massimo Montalto, A Mirijello, L Guasti, L Castiglioni, A Maresca, A Squizzato, L Campiotti, A Grossi, M Bertolotti, C Mussi, G Lancellotti, MV Libbra, G Dondi, E Pellegrini, L Carulli, M Galassi, Y Grassi, F Perticone, M Perticone, R Battaglia, M FIlice, R Maio, V Stanghellini, E Ruggeri, S del Vecchio, A Salvi, R Leonardi, G Damiani, W Capeci, A Gabrielli, M Mattioli, GP Martino, L Biondi, P Pettinari, R Ghio, A Dal Col, S Minisola, L Colangelo, M Cilli, G Labbadia, A Afeltra, B Marigliano, ME Pipita, P Castellino, L Zanoli, S Pignataro, A Gennaro, J Blanco, V Saracco, M Fogliati, C Bussolino, F Mete, M Gino, A Cittadini, C Vigorito, M Arcopinto, A Salzano, E Bobbio, AM Marra, D Sirico, G Moreo, F Gasparini, S Prolo, G Pina, A Ballestrero, F Ferrando, S Berra, S Dassi, MC Nava, B Graziella, S Baldassarre, S Fragapani, G Gruden, G Galanti, G Mascherini, C Petri, L Stefani, M Girino, V Piccinelli, F Nasso, V Gioffre, M Pasquale, G Scattolin, S Martinelli, M Turrin, L Sechi, C Catena, G Colussi, N Passariello, L Rinaldi, F Berti, G Famularo, P Tarsitani, R Castello, M Pasino, GP Ceda, MG Maggio, S Morganti, A Artoni, S Del Giacco, D Firinu, F Losa, G Paoletti, G Costanzo, G Montalto, A Licata, V Malerba, FA Montalto, A Lasco, G Basile, A Catalano, L Malatino, B Stancanelli, V Terranova, S Di Marca, R Di Quattro, L La Malfa, R Caruso, P Mecocci, C Ruggiero, V Boccardi, T Meschi, F Lauretani, A Ticinesi, A Nouvenne, P Minuz, L Fondrieschi, M Pirisi, GP Fra, D Sola, M Porta, P Riva, R Quadri, E Larovere, M Novelli, G Scanzi, C Mengoli, S Provini, L Ricevuti, E Simeone, R Scurti, F Tolloso, R Tarquini, A Valoriani, S Dolenti, G Vannini, A Tedeschi, L Trotta, R Volpi, P Bocchi, A Vignali, S Harari, C Lonati, M Cattaneo, RD Nieves, MM Alberto, AR Pedro, LP Vanessa, T Lara, CV Xavier, F Francesc, DM Jesus, BT Esperanza, DCB Esther, SP Maria, M Romero, PL Blanca, LGC Cristina, VGM Victoria, L Saez, J Bosco, SB Susana, AG Marta, GB Concepcion, FM Antonio, MG Hernandez, MP Borrego, PC Raquel, PR Florencia, GO Beatriz, CG Sara, GCC Alfonso, PM Marta, RC Alberto, AA Antonio, GG Montserrat, BRM Angel, MJ Manuel, NV Ignacio, AS Lucia, L Alfonso, RB David, VI Iniguez, RP Monica

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

10 Citazioni (Scopus)

Abstract

Background: Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register.Methods: We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects with pneumonia. Multivariate logistic analysis was used to explore the relationship between variables and mortality.Results: Among 4714 patients 284 had pneumonia. 52.8% were males and the mean age was 80 years old. 19.8% of these patients had a Barthel Index <= 40 (p < 0.0001), as well as 43.2% had a short blessed test >= 10 (p < 0.0117). In these subjects a significant CIRS for the evaluation of severity and comorbidity indexes (p < 0.0001) were present. Although a higher fasting glucose level was identified in people with pneumonia, in the multivariate logistic analysis diabetes was not independently associated with in-hospital, 3-month and 1-year mortality, whereas patients with lower Barthel Index had a higher mortality risk (odds ratio being 9.45, 6.84, 19.55 in hospital, at 3 and 12 months).Conclusion: Elderly hospitalized patients affected by pneumonia with a clinically significant disability had a higher mortality risk while diabetes does not represent an important determinant of short and long-term outcome.

Lingua originale	Inglese
pagine (da-a)	53-59
Numero di pagine	7
Rivista	European Journal of Internal Medicine
Volume	54
Numero di pubblicazione	n.d
DOI	https://doi.org/10.1016/j.ejim.2018.04.012
Stato di pubblicazione	Pubblicato - 2018

All Science Journal Classification (ASJC) codes

Medicina Interna

Keywords

Comorbidity
Diabetes
Disability
Elderly
Pneumonia

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Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1016/j.ejim.2018.04.012

Altri file e collegamenti

Cita questo

Corrao, S., Argano, C., Natoli, G., Nobili, A., Corazza, GR., Mannucci, PM., Perticone, F., Prisco, D., Silvestri, E., Emmi, G., Bettiol, A., Caterina, C., Biolo, G., Zanetti, M., Guadagni, M., Zaccari, M., Chiuch, M., Zaccari, M., Vanoli, M., ... Monica, RP. (2018). Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia. European Journal of Internal Medicine, 54(n.d), 53-59. https://doi.org/10.1016/j.ejim.2018.04.012

@article{edc84a1d760a492a8e23bd0193208131,

title = "Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia",

abstract = "Background: Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register.Methods: We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects with pneumonia. Multivariate logistic analysis was used to explore the relationship between variables and mortality.Results: Among 4714 patients 284 had pneumonia. 52.8\% were males and the mean age was 80 years old. 19.8\% of these patients had a Barthel Index <= 40 (p < 0.0001), as well as 43.2\% had a short blessed test >= 10 (p < 0.0117). In these subjects a significant CIRS for the evaluation of severity and comorbidity indexes (p < 0.0001) were present. Although a higher fasting glucose level was identified in people with pneumonia, in the multivariate logistic analysis diabetes was not independently associated with in-hospital, 3-month and 1-year mortality, whereas patients with lower Barthel Index had a higher mortality risk (odds ratio being 9.45, 6.84, 19.55 in hospital, at 3 and 12 months).Conclusion: Elderly hospitalized patients affected by pneumonia with a clinically significant disability had a higher mortality risk while diabetes does not represent an important determinant of short and long-term outcome.",

keywords = "Comorbidity, Diabetes, Disability, Elderly, Pneumonia, Comorbidity, Diabetes, Disability, Elderly, Pneumonia",

author = "S Corrao and C Argano and G Natoli and A Nobili and GR Corazza and PM Mannucci and F Perticone and D Prisco and E Silvestri and G Emmi and A Bettiol and C Caterina and G Biolo and M Zanetti and M Guadagni and M Zaccari and M Chiuch and M Zaccari and M Vanoli and G Grignani and EA Pulixi and M Bernardi and SL Bassi and L Santi and G Zaccherini and G Lupattelli and E Mannarino and V Bianconi and F Paciullo and R Alcidi and R Nuti and R Valenti and M Ruvio and S Cappelli and A Palazzuoli and D Girelli and F Busti and G Marchi and M Barbagallo and L Dominguez and F Cocita and V Beneduce and L Plances and S Corrao and G Natoli and S Mularo and M Raspanti and F Cavallaro and M Zoli and I Lazzari and M Brunori and E Fabbri and D Magalotti and R Arno and FL Pasini and PL Capecchi and G Palasciano and ME Modeo and \{Di Gennaro\}, C and MD Cappellini and D Maira and \{Di Stefano\}, V and G Fabio and S Seghezzi and M Mancarella and \{De Amicis\}, MM and \{De Luca\}, G and N Scaramellini and M Cesari and PD Rossi and S Damanti and M Clerici and F Conti and G Bonini and BB Ottolini and \{Di Sabatino\}, A and E Miceli and MV Lenti and M Pisati and CC Dominioni and G Murialdo and A Marra and F Cattaneo and R Pontremoli and V Beccati and G Nobili and MB Secchi and D Ghelfi and L Anastasio and L Sofia and M Carbone and L Anastasio and L Sofia and M Carbone and F Cipollone and MT Guagnano and E Valeriani and I Rossi and G Mancuso and D Calipari and M Bartone and G Delitala and M Berria and C Pes and A Delitala and M Muscaritoli and A Molfino and E Petrillo and G Zuccala and G D'Aurizio and G Romanelli and A Marengoni and A Zucchelli and F Manzoni and A Volpini and A Picardi and UV Gentilucci and P Gallo and C Dell'Unto and G Annoni and M Corsi and G Bellelli and S Zazzetta and P Mazzola and H Szabo and A Bonfanti and F Arturi and E Succurro and M Rubino and B Tassone and G Sesti and MG Serra and MA Bleve and L Gasbarrone and MR Sajeva and A Brucato and S Ghidoni and F Fabris and I Bertozzi and G Bogoni and MV Rabuini and E Cosi and P Scarinzi and A Amabile and E Omenetto and T Prandini and R Manfredini and F Fabbian and B Boari and \{De Giorgi\}, A and R Tiseo and \{De Giorgio\}, R and G Paolisso and MR Rizzo and C Borghi and E Strocchi and E Ianniello and M Soldati and C Sabba and FS Vella and P Suppressa and P Agosti and A Schilardi and F Loparco and \{De Vincenzo\}, GM and A Comitangelo and E Amoruso and L Fenoglio and A Falcetta and C Bracco and AL Fracanzani and S Fargion and S Tiraboschi and A Cespiati and G Oberti and G Sigon and F Peyvandi and R Rossio and B Ferrari and G Colombo and V Monzani and V Savojardo and C Folli and G Ceriani and F Salerno and G Pallini and F Dallegri and L Ottonello and L Liberale and L Caserza and K Salam and NL Liberato and T Tognin and GB Bianchi and S Giaquinto and F Purrello and \{Di Pino\}, A and S Piro and R Rozzini and L Falanga and E Spazzini and C Ferrandina and G Montrucchio and P Petitti and P Peasso and E Favale and C Poletto and R Salmi and P Gaudenzi and F Violi and L Perri and R Landolfi and Massimo Montalto and A Mirijello and L Guasti and L Castiglioni and A Maresca and A Squizzato and L Campiotti and A Grossi and M Bertolotti and C Mussi and G Lancellotti and MV Libbra and G Dondi and E Pellegrini and L Carulli and M Galassi and Y Grassi and F Perticone and M Perticone and R Battaglia and M FIlice and R Maio and V Stanghellini and E Ruggeri and \{del Vecchio\}, S and A Salvi and R Leonardi and G Damiani and W Capeci and A Gabrielli and M Mattioli and GP Martino and L Biondi and P Pettinari and R Ghio and \{Dal Col\}, A and S Minisola and L Colangelo and M Cilli and G Labbadia and A Afeltra and B Marigliano and ME Pipita and P Castellino and L Zanoli and S Pignataro and A Gennaro and J Blanco and V Saracco and M Fogliati and C Bussolino and F Mete and M Gino and A Cittadini and C Vigorito and M Arcopinto and A Salzano and E Bobbio and AM Marra and D Sirico and G Moreo and F Gasparini and S Prolo and G Pina and A Ballestrero and F Ferrando and S Berra and S Dassi and MC Nava and B Graziella and S Baldassarre and S Fragapani and G Gruden and G Galanti and G Mascherini and C Petri and L Stefani and M Girino and V Piccinelli and F Nasso and V Gioffre and M Pasquale and G Scattolin and S Martinelli and M Turrin and L Sechi and C Catena and G Colussi and N Passariello and L Rinaldi and F Berti and G Famularo and P Tarsitani and R Castello and M Pasino and GP Ceda and MG Maggio and S Morganti and A Artoni and \{Del Giacco\}, S and D Firinu and F Losa and G Paoletti and G Costanzo and G Montalto and A Licata and V Malerba and FA Montalto and A Lasco and G Basile and A Catalano and L Malatino and B Stancanelli and V Terranova and \{Di Marca\}, S and \{Di Quattro\}, R and \{La Malfa\}, L and R Caruso and P Mecocci and C Ruggiero and V Boccardi and T Meschi and F Lauretani and A Ticinesi and A Nouvenne and P Minuz and L Fondrieschi and M Pirisi and GP Fra and D Sola and M Porta and P Riva and R Quadri and E Larovere and M Novelli and G Scanzi and C Mengoli and S Provini and L Ricevuti and E Simeone and R Scurti and F Tolloso and R Tarquini and A Valoriani and S Dolenti and G Vannini and A Tedeschi and L Trotta and R Volpi and P Bocchi and A Vignali and S Harari and C Lonati and M Cattaneo and RD Nieves and MM Alberto and AR Pedro and LP Vanessa and T Lara and CV Xavier and F Francesc and DM Jesus and BT Esperanza and DCB Esther and SP Maria and M Romero and PL Blanca and LGC Cristina and VGM Victoria and L Saez and J Bosco and SB Susana and AG Marta and GB Concepcion and FM Antonio and MG Hernandez and MP Borrego and PC Raquel and PR Florencia and GO Beatriz and CG Sara and GCC Alfonso and PM Marta and RC Alberto and AA Antonio and GG Montserrat and BRM Angel and MJ Manuel and NV Ignacio and AS Lucia and L Alfonso and RB David and VI Iniguez and RP Monica",

year = "2018",

doi = "10.1016/j.ejim.2018.04.012",

language = "English",

volume = "54",

pages = "53--59",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

publisher = "Elsevier B.V.",

number = "n.d",

}

Corrao, S, Argano, C, Natoli, G, Nobili, A, Corazza, GR, Mannucci, PM, Perticone, F, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Caterina, C, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Chiuch, M, Zaccari, M, Vanoli, M, Grignani, G, Pulixi, EA, Bernardi, M, Bassi, SL, Santi, L, Zaccherini, G, Lupattelli, G, Mannarino, E, Bianconi, V, Paciullo, F, Alcidi, R, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Corrao, S, Natoli, G, Mularo, S, Raspanti, M, Cavallaro, F, Zoli, M, Lazzari, I, Brunori, M, Fabbri, E, Magalotti, D, Arno, R, Pasini, FL, Capecchi, PL, Palasciano, G, Modeo, ME, Di Gennaro, C, Cappellini, MD, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, De Amicis, MM, De Luca, G, Scaramellini, N, Cesari, M, Rossi, PD, Damanti, S, Clerici, M, Conti, F, Bonini, G, Ottolini, BB, Di Sabatino, A, Miceli, E, Lenti, MV, Pisati, M, Dominioni, CC, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Beccati, V, Nobili, G, Secchi, MB, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, MT, Valeriani, E, Rossi, I, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Pes, C, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Marengoni, A, Zucchelli, A, Manzoni, F, Volpini, A, Picardi, A, Gentilucci, UV, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Tassone, B, Sesti, G, Serra, MG, Bleve, MA, Gasbarrone, L, Sajeva, MR, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, MV, Cosi, E, Scarinzi, P, Amabile, A, Omenetto, E, Prandini, T, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, De Giorgio, R, Paolisso, G, Rizzo, MR, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Sabba, C, Vella, FS, Suppressa, P, Agosti, P, Schilardi, A, Loparco, F, De Vincenzo, GM, Comitangelo, A, Amoruso, E, Fenoglio, L, Falcetta, A, Bracco, C, Fracanzani, AL, Fargion, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Salerno, F, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, NL, Tognin, T, Bianchi, GB, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Peasso, P, Favale, E, Poletto, C, Salmi, R, Gaudenzi, P, Violi, F, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, MV, Dondi, G, Pellegrini, E, Carulli, L, Galassi, M, Grassi, Y, Perticone, F, Perticone, M, Battaglia, R, FIlice, M, Maio, R, Stanghellini, V, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Capeci, W, Gabrielli, A, Mattioli, M, Martino, GP, Biondi, L, Pettinari, P, Ghio, R, Dal Col, A, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, ME, Castellino, P, Zanoli, L, Pignataro, S, Gennaro, A, Blanco, J, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Marra, AM, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, MC, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffre, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Ceda, GP, Maggio, MG, Morganti, S, Artoni, A, Del Giacco, S, Firinu, D, Losa, F, Paoletti, G, Costanzo, G, Montalto, G, Licata, A, Malerba, V, Montalto, FA, Lasco, A, Basile, G, Catalano, A, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, GP, Sola, D, Porta, M, Riva, P, Quadri, R, Larovere, E, Novelli, M, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Nieves, RD, Alberto, MM, Pedro, AR, Vanessa, LP, Lara, T, Xavier, CV, Francesc, F, Jesus, DM, Esperanza, BT, Esther, DCB, Maria, SP, Romero, M, Blanca, PL, Cristina, LGC, Victoria, VGM, Saez, L, Bosco, J, Susana, SB, Marta, AG, Concepcion, GB, Antonio, FM, Hernandez, MG, Borrego, MP, Raquel, PC, Florencia, PR, Beatriz, GO, Sara, CG, Alfonso, GCC, Marta, PM, Alberto, RC, Antonio, AA, Montserrat, GG, Angel, BRM, Manuel, MJ, Ignacio, NV, Lucia, AS, Alfonso, L, David, RB, Iniguez, VI & Monica, RP 2018, 'Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia', European Journal of Internal Medicine, vol. 54, n. n.d, pagg. 53-59. https://doi.org/10.1016/j.ejim.2018.04.012

TY - JOUR

T1 - Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

AU - Corrao, S

AU - Argano, C

AU - Natoli, G

AU - Nobili, A

AU - Corazza, GR

AU - Mannucci, PM

AU - Perticone, F

AU - Prisco, D

AU - Silvestri, E

AU - Emmi, G

AU - Bettiol, A

AU - Caterina, C

AU - Biolo, G

AU - Zanetti, M

AU - Guadagni, M

AU - Zaccari, M

AU - Chiuch, M

AU - Zaccari, M

AU - Vanoli, M

AU - Grignani, G

AU - Pulixi, EA

AU - Bernardi, M

AU - Bassi, SL

AU - Santi, L

AU - Zaccherini, G

AU - Lupattelli, G

AU - Mannarino, E

AU - Bianconi, V

AU - Paciullo, F

AU - Alcidi, R

AU - Nuti, R

AU - Valenti, R

AU - Ruvio, M

AU - Cappelli, S

AU - Palazzuoli, A

AU - Girelli, D

AU - Busti, F

AU - Marchi, G

AU - Barbagallo, M

AU - Dominguez, L

AU - Cocita, F

AU - Beneduce, V

AU - Plances, L

AU - Corrao, S

AU - Natoli, G

AU - Mularo, S

AU - Raspanti, M

AU - Cavallaro, F

AU - Zoli, M

AU - Lazzari, I

AU - Brunori, M

AU - Fabbri, E

AU - Magalotti, D

AU - Arno, R

AU - Pasini, FL

AU - Capecchi, PL

AU - Palasciano, G

AU - Modeo, ME

AU - Di Gennaro, C

AU - Cappellini, MD

AU - Maira, D

AU - Di Stefano, V

AU - Fabio, G

AU - Seghezzi, S

AU - Mancarella, M

AU - De Amicis, MM

AU - De Luca, G

AU - Scaramellini, N

AU - Cesari, M

AU - Rossi, PD

AU - Damanti, S

AU - Clerici, M

AU - Conti, F

AU - Bonini, G

AU - Ottolini, BB

AU - Di Sabatino, A

AU - Miceli, E

AU - Lenti, MV

AU - Pisati, M

AU - Dominioni, CC

AU - Murialdo, G

AU - Marra, A

AU - Cattaneo, F

AU - Pontremoli, R

AU - Beccati, V

AU - Nobili, G

AU - Secchi, MB

AU - Ghelfi, D

AU - Anastasio, L

AU - Sofia, L

AU - Carbone, M

AU - Anastasio, L

AU - Sofia, L

AU - Carbone, M

AU - Cipollone, F

AU - Guagnano, MT

AU - Valeriani, E

AU - Rossi, I

AU - Mancuso, G

AU - Calipari, D

AU - Bartone, M

AU - Delitala, G

AU - Berria, M

AU - Pes, C

AU - Delitala, A

AU - Muscaritoli, M

AU - Molfino, A

AU - Petrillo, E

AU - Zuccala, G

AU - D'Aurizio, G

AU - Romanelli, G

AU - Marengoni, A

AU - Zucchelli, A

AU - Manzoni, F

AU - Volpini, A

AU - Picardi, A

AU - Gentilucci, UV

AU - Gallo, P

AU - Dell'Unto, C

AU - Annoni, G

AU - Corsi, M

AU - Bellelli, G

AU - Zazzetta, S

AU - Mazzola, P

AU - Szabo, H

AU - Bonfanti, A

AU - Arturi, F

AU - Succurro, E

AU - Rubino, M

AU - Tassone, B

AU - Sesti, G

AU - Serra, MG

AU - Bleve, MA

AU - Gasbarrone, L

AU - Sajeva, MR

AU - Brucato, A

AU - Ghidoni, S

AU - Fabris, F

AU - Bertozzi, I

AU - Bogoni, G

AU - Rabuini, MV

AU - Cosi, E

AU - Scarinzi, P

AU - Amabile, A

AU - Omenetto, E

AU - Prandini, T

AU - Manfredini, R

AU - Fabbian, F

AU - Boari, B

AU - De Giorgi, A

AU - Tiseo, R

AU - De Giorgio, R

AU - Paolisso, G

AU - Rizzo, MR

AU - Borghi, C

AU - Strocchi, E

AU - Ianniello, E

AU - Soldati, M

AU - Sabba, C

AU - Vella, FS

AU - Suppressa, P

AU - Agosti, P

AU - Schilardi, A

AU - Loparco, F

AU - De Vincenzo, GM

AU - Comitangelo, A

AU - Amoruso, E

AU - Fenoglio, L

AU - Falcetta, A

AU - Bracco, C

AU - Fracanzani, AL

AU - Fargion, S

AU - Tiraboschi, S

AU - Cespiati, A

AU - Oberti, G

AU - Sigon, G

AU - Peyvandi, F

AU - Rossio, R

AU - Ferrari, B

AU - Colombo, G

AU - Monzani, V

AU - Savojardo, V

AU - Folli, C

AU - Ceriani, G

AU - Salerno, F

AU - Pallini, G

AU - Dallegri, F

AU - Ottonello, L

AU - Liberale, L

AU - Caserza, L

AU - Salam, K

AU - Liberato, NL

AU - Tognin, T

AU - Bianchi, GB

AU - Giaquinto, S

AU - Purrello, F

AU - Di Pino, A

AU - Piro, S

AU - Rozzini, R

AU - Falanga, L

AU - Spazzini, E

AU - Ferrandina, C

AU - Montrucchio, G

AU - Petitti, P

AU - Peasso, P

AU - Favale, E

AU - Poletto, C

AU - Salmi, R

AU - Gaudenzi, P

AU - Violi, F

AU - Perri, L

AU - Landolfi, R

AU - Montalto, Massimo

AU - Mirijello, A

AU - Guasti, L

AU - Castiglioni, L

AU - Maresca, A

AU - Squizzato, A

AU - Campiotti, L

AU - Grossi, A

AU - Bertolotti, M

AU - Mussi, C

AU - Lancellotti, G

AU - Libbra, MV

AU - Dondi, G

AU - Pellegrini, E

AU - Carulli, L

AU - Galassi, M

AU - Grassi, Y

AU - Perticone, F

AU - Perticone, M

AU - Battaglia, R

AU - FIlice, M

AU - Maio, R

AU - Stanghellini, V

AU - Ruggeri, E

AU - del Vecchio, S

AU - Salvi, A

AU - Leonardi, R

AU - Damiani, G

AU - Capeci, W

AU - Gabrielli, A

AU - Mattioli, M

AU - Martino, GP

AU - Biondi, L

AU - Pettinari, P

AU - Ghio, R

AU - Dal Col, A

AU - Minisola, S

AU - Colangelo, L

AU - Cilli, M

AU - Labbadia, G

AU - Afeltra, A

AU - Marigliano, B

AU - Pipita, ME

AU - Castellino, P

AU - Zanoli, L

AU - Pignataro, S

AU - Gennaro, A

AU - Blanco, J

AU - Saracco, V

AU - Fogliati, M

AU - Bussolino, C

AU - Mete, F

AU - Gino, M

AU - Cittadini, A

AU - Vigorito, C

AU - Arcopinto, M

AU - Salzano, A

AU - Bobbio, E

AU - Marra, AM

AU - Sirico, D

AU - Moreo, G

AU - Gasparini, F

AU - Prolo, S

AU - Pina, G

AU - Ballestrero, A

AU - Ferrando, F

AU - Berra, S

AU - Dassi, S

AU - Nava, MC

AU - Graziella, B

AU - Baldassarre, S

AU - Fragapani, S

AU - Gruden, G

AU - Galanti, G

AU - Mascherini, G

AU - Petri, C

AU - Stefani, L

AU - Girino, M

AU - Piccinelli, V

AU - Nasso, F

AU - Gioffre, V

AU - Pasquale, M

AU - Scattolin, G

AU - Martinelli, S

AU - Turrin, M

AU - Sechi, L

AU - Catena, C

AU - Colussi, G

AU - Passariello, N

AU - Rinaldi, L

AU - Berti, F

AU - Famularo, G

AU - Tarsitani, P

AU - Castello, R

AU - Pasino, M

AU - Ceda, GP

AU - Maggio, MG

AU - Morganti, S

AU - Artoni, A

AU - Del Giacco, S

AU - Firinu, D

AU - Losa, F

AU - Paoletti, G

AU - Costanzo, G

AU - Montalto, G

AU - Licata, A

AU - Malerba, V

AU - Montalto, FA

AU - Lasco, A

AU - Basile, G

AU - Catalano, A

AU - Malatino, L

AU - Stancanelli, B

AU - Terranova, V

AU - Di Marca, S

AU - Di Quattro, R

AU - La Malfa, L

AU - Caruso, R

AU - Mecocci, P

AU - Ruggiero, C

AU - Boccardi, V

AU - Meschi, T

AU - Lauretani, F

AU - Ticinesi, A

AU - Nouvenne, A

AU - Minuz, P

AU - Fondrieschi, L

AU - Pirisi, M

AU - Fra, GP

AU - Sola, D

AU - Porta, M

AU - Riva, P

AU - Quadri, R

AU - Larovere, E

AU - Novelli, M

AU - Scanzi, G

AU - Mengoli, C

AU - Provini, S

AU - Ricevuti, L

AU - Simeone, E

AU - Scurti, R

AU - Tolloso, F

AU - Tarquini, R

AU - Valoriani, A

AU - Dolenti, S

AU - Vannini, G

AU - Tedeschi, A

AU - Trotta, L

AU - Volpi, R

AU - Bocchi, P

AU - Vignali, A

AU - Harari, S

AU - Lonati, C

AU - Cattaneo, M

AU - Nieves, RD

AU - Alberto, MM

AU - Pedro, AR

AU - Vanessa, LP

AU - Lara, T

AU - Xavier, CV

AU - Francesc, F

AU - Jesus, DM

AU - Esperanza, BT

AU - Esther, DCB

AU - Maria, SP

AU - Romero, M

AU - Blanca, PL

AU - Cristina, LGC

AU - Victoria, VGM

AU - Saez, L

AU - Bosco, J

AU - Susana, SB

AU - Marta, AG

AU - Concepcion, GB

AU - Antonio, FM

AU - Hernandez, MG

AU - Borrego, MP

AU - Raquel, PC

AU - Florencia, PR

AU - Beatriz, GO

AU - Sara, CG

AU - Alfonso, GCC

AU - Marta, PM

AU - Alberto, RC

AU - Antonio, AA

AU - Montserrat, GG

AU - Angel, BRM

AU - Manuel, MJ

AU - Ignacio, NV

AU - Lucia, AS

AU - Alfonso, L

AU - David, RB

AU - Iniguez, VI

AU - Monica, RP

PY - 2018

Y1 - 2018

N2 - Background: Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register.Methods: We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects with pneumonia. Multivariate logistic analysis was used to explore the relationship between variables and mortality.Results: Among 4714 patients 284 had pneumonia. 52.8% were males and the mean age was 80 years old. 19.8% of these patients had a Barthel Index <= 40 (p < 0.0001), as well as 43.2% had a short blessed test >= 10 (p < 0.0117). In these subjects a significant CIRS for the evaluation of severity and comorbidity indexes (p < 0.0001) were present. Although a higher fasting glucose level was identified in people with pneumonia, in the multivariate logistic analysis diabetes was not independently associated with in-hospital, 3-month and 1-year mortality, whereas patients with lower Barthel Index had a higher mortality risk (odds ratio being 9.45, 6.84, 19.55 in hospital, at 3 and 12 months).Conclusion: Elderly hospitalized patients affected by pneumonia with a clinically significant disability had a higher mortality risk while diabetes does not represent an important determinant of short and long-term outcome.

AB - Background: Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register.Methods: We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects with pneumonia. Multivariate logistic analysis was used to explore the relationship between variables and mortality.Results: Among 4714 patients 284 had pneumonia. 52.8% were males and the mean age was 80 years old. 19.8% of these patients had a Barthel Index <= 40 (p < 0.0001), as well as 43.2% had a short blessed test >= 10 (p < 0.0117). In these subjects a significant CIRS for the evaluation of severity and comorbidity indexes (p < 0.0001) were present. Although a higher fasting glucose level was identified in people with pneumonia, in the multivariate logistic analysis diabetes was not independently associated with in-hospital, 3-month and 1-year mortality, whereas patients with lower Barthel Index had a higher mortality risk (odds ratio being 9.45, 6.84, 19.55 in hospital, at 3 and 12 months).Conclusion: Elderly hospitalized patients affected by pneumonia with a clinically significant disability had a higher mortality risk while diabetes does not represent an important determinant of short and long-term outcome.

KW - Comorbidity

KW - Diabetes

KW - Disability

KW - Elderly

KW - Pneumonia

KW - Comorbidity

KW - Diabetes

KW - Disability

KW - Elderly

KW - Pneumonia

UR - https://publicatt.unicatt.it/handle/10807/172402

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85046353419&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046353419&origin=inward

U2 - 10.1016/j.ejim.2018.04.012

DO - 10.1016/j.ejim.2018.04.012

M3 - Article

SN - 0953-6205

VL - 54

SP - 53

EP - 59

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

IS - n.d

ER -

Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

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