Direct and indirect comparison meta-analysis demonstrates the superiority of sirolimus- versus paclitaxel-eluting stents across 5854 patients.

Francesco Burzotta, Filippo Crea, Giuseppe Biondi Zoccai, Marzia Lotrionte, Antonio Abbate, Luca Testa, M Valgimigli, P. Agostoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

There is ongoing debate to identify the most effective, safe and cost-beneficial drug-eluting stent, between the two currently approved and used devices, i.e. sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES). To date, head-to-head comparison studies of SES vs PES have been however limited by relatively small sample sizes and the low number of events typically associated with these highly effective coronary devices. To overcome the drawbacks of single trials, direct and indirect comparison meta-analyses have been designed and conducted to thoroughly compare sirolimus- vs paclitaxel eluting-stents. This article provides results of a pooled analysis of such indirect and direct comparisons, definitively demonstrating across 5854 patients the superiority of SES in comparison to PES (odds ratio 0.62 [95% confidence interval 0.50-0.75], p<0.0001 for binary angiographic restenosis, and odds ratio 0.66 [0.52-0.84], p=0.0008 for target lesion revascularization). Indeed, such combination of direct and indirect comparisons should also be envisaged to soundly and timely appraise the next generation of drug-eluting stents.
Lingua originaleEnglish
pagine (da-a)104-105
Numero di pagine2
RivistaINTERNATIONAL JOURNAL OF CARDIOLOGY
Stato di pubblicazionePubblicato - 2007

Keywords

  • PES
  • SES

Fingerprint

Entra nei temi di ricerca di 'Direct and indirect comparison meta-analysis demonstrates the superiority of sirolimus- versus paclitaxel-eluting stents across 5854 patients.'. Insieme formano una fingerprint unica.

Cita questo