Abstract
Background: In a previous study we demonstrated that high-frequency oscillations (HFOs) elicited by median nerve
stimulation are significantly correlated to clinical fluctuations of migraine. We aimed at verifying whether clinical fluctuations
and HFO changes are correlated to N20 somatosensory evoked potential (SEP) recovery cycle, which is likely to
reflect the functional refractoriness of primary somatosensory cortex neurons.
Methods: We analysed both HFOs and N20 SEP recovery cycle to paired stimulation in 21 migraine patients and 18
healthy volunteers.
Results: Shortened recovery cycle correlated with low-amplitude HFOs as well as with clinical worsening. By contrast,
prolonged recovery cycle correlated with enhanced HFOs, as well as with spontaneous clinical improvement.
Conclusions: In our migraine patients the strict relationship between presynaptic HFO amplitude and N20 recovery
function suggests that changes of both parameters might be caused by modifications of the thalamo-cortical drive.
Our findings suggest that the thalamo-cortical drive during interictal stages could fluctuate from abnormally high to
abnormally low levels, depending on mechanisms which reduce cortical excitability in spontaneously improving patients,
and increase cortical excitability in spontaneously worsening ones.
Lingua originale | English |
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pagine (da-a) | 1035-1047 |
Rivista | Cephalalgia |
Volume | 33 |
DOI | |
Stato di pubblicazione | Pubblicato - 2013 |
Keywords
- migraine