TY - JOUR
T1 - Differences in ultrasound features of papillations in unilocular-solid adnexal cysts: a retrospective international multicenter study
AU - Landolfo, C.
AU - Valentin, L.
AU - Franchi, D.
AU - Van Holsbeke, C.
AU - Fruscio, R.
AU - Froyman, W.
AU - Sladkevicius, P.
AU - Kaijser, J.
AU - Ameye, L.
AU - Bourne, T.
AU - Savelli, L.
AU - Coosemans, A.
AU - Testa, Antonia Carla
AU - Timmerman, D.
PY - 2018
Y1 - 2018
N2 - Objectives: To identify ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. Methods: From the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers, we identified patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components. All patients had undergone transvaginal ultrasound between 1999 and 2007 or 2009 and 2012, by an experienced examiner following the IOTA research protocol. Information on four ultrasound features of papillations had been collected prospectively. Information on a further seven ultrasound features was collected retrospectively from electronic or paper ultrasound images of good quality. The histological diagnosis of the surgically removed adnexal lesion was considered the gold standard. Results: Of 204 masses included, 131 (64.2%) were benign, 42 (20.6%) were borderline tumors, 30 (14.7%) were primary invasive tumors and one (0.5%) was a metastasis. Multivariate logistic regression analysis showed the following ultrasound features to be associated independently with malignancy: height of the largest papillation, presence of blood flow in papillations, papillation confluence or dissemination, and shadows behind papillations. Shadows decreased the odds of malignancy, while the other features increased them. Conclusion: We have identified ultrasound features that can help to discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. Our results need to be confirmed in prospective studies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
AB - Objectives: To identify ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. Methods: From the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers, we identified patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components. All patients had undergone transvaginal ultrasound between 1999 and 2007 or 2009 and 2012, by an experienced examiner following the IOTA research protocol. Information on four ultrasound features of papillations had been collected prospectively. Information on a further seven ultrasound features was collected retrospectively from electronic or paper ultrasound images of good quality. The histological diagnosis of the surgically removed adnexal lesion was considered the gold standard. Results: Of 204 masses included, 131 (64.2%) were benign, 42 (20.6%) were borderline tumors, 30 (14.7%) were primary invasive tumors and one (0.5%) was a metastasis. Multivariate logistic regression analysis showed the following ultrasound features to be associated independently with malignancy: height of the largest papillation, presence of blood flow in papillations, papillation confluence or dissemination, and shadows behind papillations. Shadows decreased the odds of malignancy, while the other features increased them. Conclusion: We have identified ultrasound features that can help to discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. Our results need to be confirmed in prospective studies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
KW - Adnexa Uteri
KW - Adnexal Diseases
KW - Adult
KW - Cysts
KW - Diagnosis, Differential
KW - Female
KW - Humans
KW - Middle Aged
KW - Obstetrics and Gynecology
KW - Ovarian Neoplasms
KW - Predictive Value of Tests
KW - Radiological and Ultrasound Technology
KW - Radiology, Nuclear Medicine and Imaging
KW - Reproductive Medicine
KW - Retrospective Studies
KW - Ultrasonography, Doppler, Color
KW - ovarian neoplasm
KW - papillary projection
KW - ultrasonography
KW - Adnexa Uteri
KW - Adnexal Diseases
KW - Adult
KW - Cysts
KW - Diagnosis, Differential
KW - Female
KW - Humans
KW - Middle Aged
KW - Obstetrics and Gynecology
KW - Ovarian Neoplasms
KW - Predictive Value of Tests
KW - Radiological and Ultrasound Technology
KW - Radiology, Nuclear Medicine and Imaging
KW - Reproductive Medicine
KW - Retrospective Studies
KW - Ultrasonography, Doppler, Color
KW - ovarian neoplasm
KW - papillary projection
KW - ultrasonography
UR - http://hdl.handle.net/10807/127655
UR - http://obgyn.onlinelibrary.wiley.com/hub/journal/10.1002/(issn)1469-0705/
U2 - 10.1002/uog.18951
DO - 10.1002/uog.18951
M3 - Article
SN - 0960-7692
VL - 52
SP - 269
EP - 278
JO - ULTRASOUND IN OBSTETRICS & GYNECOLOGY
JF - ULTRASOUND IN OBSTETRICS & GYNECOLOGY
ER -