Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia

Luca Laurenti, Alessandra Tedeschi, Concetta Conticello, Rita Rizzi, Giulia Benevolo, Maria Teresa Petrucci, Francesco Zaja, Marzia Varettoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Firstly, to provide a framework of the broad spectrum of IgM-associated disorders: (1) monoclonal gammopathy of undetermined significance (MGUS); (2) Waldenström macroglobulinemia (WM); (3) IgM-related disorders (among which hyperviscosity syndrome, light chain amyloidosis, cold agglutinin disease, cryoglobulinaemia, IgM neuropathy, Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome, Castleman disease); (4) IgM-secreting multiple myeloma (IgM-MM); and (5) other lymphoproliferative disorders which may be associated with IgM (such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and B-cell non Hodgkin lymphoma). Secondly, to give a detailed insight regarding diagnosis and treatment of WM.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaHematological Oncology
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • IgM monoclonal gammopathy
  • IgM-related disorders
  • IgM-secreting multiple myeloma
  • Waldenström macroglobulinemia

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