Diagnostic and Prognostic Role of HBME-1, Galectin-3, and β-Catenin in Poorly Differentiated and Anaplastic Thyroid Carcinomas.

Luca Revelli, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda, E Rossi, P Straccia, M Palumbo, E Stigliano, G Santeusanio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

AIM:: Thyroid cancer represents the first endocrine malignant neoplasm, accounting for 1% of human malignancy. The majority of which are well-differentiated cancer representing up to 90% of thyroid cancer and pursuing a favorable clinical course. The groups of poorly differentiated thyroid cancer (PDC) and anaplastic thyroid cancer (ATC) have a poor outcome and need a strict clinical surveillance. MATERIALS AND METHODS:: Thirty-four cases including 23 PDC/insular cancer and 9 ATC were examined for the expression of an immunohistochemical panel made up by HBME-1, galectin-3, and β-catenin and correlated either with histologic prognostic parameters or the overall surveillance. RESULTS:: HBME-1 and galectin-3 were expressed in 100% of the PDC/insular cases and in none of the ATC cases. The data for β-catenin pointed out an 80% expression (12/15) in the PDCs and only a focal and nonspecific positivity in the ATCs. A β-catenin-positive expression was found in all patients with a worse outcome/death and in the presence of vascular invasion and metastatic disease. All 3 PDC patients with β-catenin negativity are alive, whereas only 41% (5/12) are alive in the β-catenin-positive group. CONCLUSIONS:: Our data set up the idea that PDC represents an intermediate step in the biological process of dedifferentiation of thyroid tumors toward ATC. This shift is underlined by the β-catenin expression, which seems to be related to a worse prognostic behavior. HBME-1 and galectin-3 show a similar pattern in PDC compared with well-differentiated carcinoma, whereas they are not expressed, as well as β-catenin, in anaplastic carcinomas.
Lingua originaleEnglish
pagine (da-a)1-2
Numero di pagine2
RivistaApplied Immunohistochemistry and Molecular Morphology
Stato di pubblicazionePubblicato - 2012

Keywords

  • HBME-1, Galectin-3, and β-Catenin in
  • Poorly Differentiated and Anaplastic Thyroid Carcinomas

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