TY - JOUR
T1 - Diagnostic accuracy of positron emission tomography/computed tomography-driven biopsy for the diagnosis of lymphoma
AU - Broccoli, Alessandro
AU - Nanni, Cristina
AU - Cappelli, Alberta
AU - Bacci, Francesco
AU - Gasbarrini, Alessandro
AU - Gasbarrini, Antonio
AU - Tabacchi, Elena
AU - Piovani, Carlo
AU - Argnani, Lisa
AU - Ghermandi, Riccardo
AU - Sabattini, Elena
AU - Golfieri, Rita
AU - Fanti, Stefano
AU - Zinzani, Pier Luigi
PY - 2020
Y1 - 2020
N2 - Introduction: Biopsy of affected tissue is required for lymphoma diagnosis and to plan treatment. Open incisional biopsy is traditionally the method of choice. Nevertheless, it requires hospitalization, availability of an operating room, and sometimes general anesthesia, and it is associated with several drawbacks. Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) can be potentially used to drive biopsy to the most metabolically active area within a lymph node or extranodal masses. Methods: A study of diagnostic accuracy was conducted to assess the performance of a PET-driven needle biopsy in patients with suspect active lymphoma. Results: Overall, 99 procedures have been performed: three (3.0%) were interrupted because of pain but were successfully repeated in two cases. Median SUVmax of target lesions was 10.7. In 84/96 cases, the tissue was considered adequate to formulate a diagnosis (diagnostic yield of 87.5%) and to guide the following clinical decision. The target specimen was a lymph node in 60 cases and an extranodal site in 36. No serious adverse events occurred. The sensitivity of this procedure was 96%, with a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 75%. Conclusion: Patients can benefit from a minimally invasive procedure which allows a timely and accurate diagnosis of lymphoma at onset or relapse.
AB - Introduction: Biopsy of affected tissue is required for lymphoma diagnosis and to plan treatment. Open incisional biopsy is traditionally the method of choice. Nevertheless, it requires hospitalization, availability of an operating room, and sometimes general anesthesia, and it is associated with several drawbacks. Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) can be potentially used to drive biopsy to the most metabolically active area within a lymph node or extranodal masses. Methods: A study of diagnostic accuracy was conducted to assess the performance of a PET-driven needle biopsy in patients with suspect active lymphoma. Results: Overall, 99 procedures have been performed: three (3.0%) were interrupted because of pain but were successfully repeated in two cases. Median SUVmax of target lesions was 10.7. In 84/96 cases, the tissue was considered adequate to formulate a diagnosis (diagnostic yield of 87.5%) and to guide the following clinical decision. The target specimen was a lymph node in 60 cases and an extranodal site in 36. No serious adverse events occurred. The sensitivity of this procedure was 96%, with a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 75%. Conclusion: Patients can benefit from a minimally invasive procedure which allows a timely and accurate diagnosis of lymphoma at onset or relapse.
KW - Biopsy
KW - Computed tomography
KW - Diagnosis
KW - Diagnostic accuracy
KW - Driven biopsy
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Lymphoma
KW - Neoplasm Recurrence, Local
KW - Positron Emission Tomography Computed Tomography
KW - Positron emission tomography
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Retrospective Studies
KW - Biopsy
KW - Computed tomography
KW - Diagnosis
KW - Diagnostic accuracy
KW - Driven biopsy
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Lymphoma
KW - Neoplasm Recurrence, Local
KW - Positron Emission Tomography Computed Tomography
KW - Positron emission tomography
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Retrospective Studies
UR - http://hdl.handle.net/10807/205609
U2 - 10.1007/s00259-020-04913-9
DO - 10.1007/s00259-020-04913-9
M3 - Article
SN - 1619-7070
VL - 47
SP - 3058
EP - 3065
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
ER -