Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

Walsh SLF; Maher TM; M Kolb; V Poletti; R Nusser; Luca Richeldi; C Vancheri; Wilsher ML; Antoniou KM; J Behr; E Bendstrup; K Brown; L Calandriello; Corte TJ; V Cottin; B Crestani; K Flaherty; I Glaspole; J Grutters; Y Inoue; M Kokosi; Y Kondoh; V Kouranos; M Kreuter; K Johannson; E Judge; B Ley; G Margaritopoulos; Martinez FJ; M Molina-Molina; A Morais; H Nunes; G Raghu; Ryerson CJ; M Selman; P Spagnolo; H Taniguchi; S Tomassetti; D Valeyre; M Wijsenbeek; W Wuyts; D Hansell; A Wells; Zhu PS; Y Yuan; Fukuda C Yoshito; Y Yoshimatsu; A Xaubet; Wong AM; P White; G Westney; A West; T Wessendorf; Y Waseda; C Wang; Vienna JM; Ivanov J Videnovic; Zygmunt V Vicens; Venero Caceres MC; Pinto G Velasquez; E Veitch; M Vasakova; F Varone; Varela BE; Hal P Van; De Ven M Van; Der Lee I Van; Den Toorn L Van; Gajate A Urrutia; J Urban; Ugarte Fornell LG; A Tzouvelekis; K Twohig; A Turner; S. Trujillo; A Triani; D Traila; V Torres; H Tomioka; K Tomii; R Tomic; C Toma; Akyil F Tokgoz; K Tobino; R Tobar; A Tiwari; R Tibana; X Tian; M Thillai; W Tham; F Teo; Trkanjec J Tekavec; P Teixeira; D Tarpey; L Tapias; K Tanizawa; Y Tanino; T Takada; G Tabaj; E Szolnoki; R Swarnakar; I Strambu; M Sterclova; K Spinks; Soo CI; A Soltani; S Solanki; E Sobh; Soares MR; J Smith; B Smith; P Slocum; H Slabbynck; I Sivokozov; A Shifren; Shen SM; C Sharp; A Shanmuganathan; A Sebastiani; S Scarlata; R Savas; S Sasaki; J Santeliz; Santana ANC; R Sanchez; M Salinas; S Saito; F Ryan; Royo Prats JA; E Rosi; H Rokadia; Perez A Robles; Ortega P Rivera; Ramirez M Rio; S Righetti; C Reichner; C Ravaglia; P Ratanawatkul; V Ramalingam; A Rajasekaran; E Radzikowska; Ra SW; S Quadrelli; J Precerutti; J Prasad; D Popa; S Pizzalato; W Piotrowski; A Pineiro; D Piloni; Golubicic T Peros; R Perez; C Pereira; B Pereira; M Perch; N Patel; D Patel; I Papanikolaou; D Papakosta; E Panselinas; Pang YK; P Pandya; E Padrao; Kumbasar O Ozdemir; Overbeek MJ; Minasian A Otto; D O'Riordan; J Ora; J Oldham; O Okutan; S Ohshimo; Oguzulgen IK; T Ogura; T O'Donnell; C O'Dochartaigh; S O'Beirne; L Novikova; L Novelli; I Noth; Mendes Neto N Nogueira; M Niroumand; A Nieto; A Neves; A Nambiar; S Nair; R Nadama; E Murtagh; M Mura; Quernheim J Muller; A Mukhopadhyay; S Mukherjee; J Morisset; O Moran; J Mooney; J Moller; N Mogulkoc; A Miyamoto; B Milenkovic; S Mette; M Mejia; F Mei; M Mazzei; T Matsuda; C Mason; Frances M Martinez; S Mannarino; E Mancuzo; F Malli; P Malhotra; M Maillo; J Maia; M Mahdavian; F Madsen; T Luckhardt; W Lucht; Low SY; Lopez Miguel CP; R Lipchik; S Levy; K Levin; Lee KL; D Lederer; Lammi MR; Kwan HY; S Kukreja; A Kruavit; M Kotecki; L Kolilekas; H Knoop; E Kiyan; T Kishaba; Biggs M King; Khor YH; A Khan; N Khalil; R Kedia; N Kebba; Dourado L Kawano; K Kapitan; C. D Kan; A. F Kalyoncu; M Kalluri; Y Kabasakal; S Jyothula; Juretschke MA; D Jovanovic; R Jonkers; H Jo; S Izumi; H Ishii; S Ikeda; A Ibrahim; C Hyldgaard; G Hunninghake; T Huie; A Hufton; X Hu; W. C Hseih; R Hoyos; R Hoyles; Rodriguez O Holguin; M. P Hogan; U Hodgson; Sogoloff H Hilkin; E Herrera; B. M Henry; M Hellemons; A Hecimovic; R Hayashi; S Hart; S Harari; S Haney; N Hambly; R Hakkim; M Gutierrez; R Gripaldo; A Gomez; N Goh; R Godoy; C Gilbert; I Giannarakis; S Gasparini; P Garcha; S Furtado; A Fois; Page P Flood; S Fletcher; E Fiss; Casas J Figueroa; Casas M Figueroa; Fiddler CA; G Ferrara; Casares M Fernandez; C Felton; P Faverio; Fabro AT; A Estrada; P Errhalt; N Enomoto; Enghelmayer JI; Kersh K El; G Eiger; A Dubaniewicz; F Drakopanagiotakis; S Disayabutr; A Dijkstra; Diaz Patino JC; Diaz Castanon JJ; S Dhooria; Dhasmana DJ; Rosa M De; Luca S De; A Delobbe; D Delgado; C Delgado; La Fuente I De; Kruif M De; Gier M De; Andrade J De; Davidsen JR; B Daoud; K Dalhoff; Cotera Solano JV; Costa AN; S Coronel; M Confalonieri; L Conemans; A Comellas; S Colella; S Clemente; J Clark; M Ciuffreda; Chung CL; Chong SG; D Chirita; Chen PL; N Chaudhuri; D Chambers; G Chalmers; D Chairman; Chai GT; Chaves R Chacon; V Cetinsu; M Ceruti; Ceballos Zuniga CO; D Castillo; Carbone RG; A Caminati; Callejas Gonzalez FJ; M Butler; C Bustos; M Bukowczan; I Buendia; G Brunetti; B Brockway; P Bresser; J Breseghello; D Bouros; Botero Zaccour JA; G Borzone; R Borie; Blum HC; J Blank; A Biswas; D Bennett; M Benjamin; Belaconi IN; P Beirne; L Beckert; S Bastiampillai; R Bascom; B Bartholmai; M Barros; Ban AYL; E Balestro; B Baldi; Martinez J Baddini; A Baburao; S Babu; A Averyanov; S Avdeev; R Athanazio; E Atahan; B Asuquo; D Assayag; J Antuni; S Antillon; Anderson KC; A Anderson; F Alwani; G Altinisik; N Alsouofi; Allam JS; Jahdali H Al; Farttoosi A Al; T Alfaro; Busaidi N Al; Foumani A Alavi; Agreda Vedia MG; A Agarwal; F Afridi; Adeyeye OO; A Adegunsoye; H Adamali; A Abedini

doi:10.1183/13993003.00936-2017

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

Walsh SLF^*, Maher TM, M Kolb, V Poletti, R Nusser, Luca Richeldi, C Vancheri, Wilsher ML, Antoniou KM, J Behr, E Bendstrup, K Brown, L Calandriello, Corte TJ, V Cottin, B Crestani, K Flaherty, I Glaspole, J Grutters, Y InoueM Kokosi, Y Kondoh, V Kouranos, M Kreuter, K Johannson, E Judge, B Ley, G Margaritopoulos, Martinez FJ, M Molina-Molina, A Morais, H Nunes, G Raghu, Ryerson CJ, M Selman, P Spagnolo, H Taniguchi, S Tomassetti, D Valeyre, M Wijsenbeek, W Wuyts, D Hansell, A Wells, Zhu PS, Y Yuan, Fukuda C Yoshito, Y Yoshimatsu, A Xaubet, Wong AM, P White, G Westney, A West, T Wessendorf, Y Waseda, C Wang, Vienna JM, Ivanov J Videnovic, Zygmunt V Vicens, Venero Caceres MC, Pinto G Velasquez, E Veitch, M Vasakova, F Varone, Varela BE, Hal P Van, De Ven M Van, Der Lee I Van, Den Toorn L Van, Gajate A Urrutia, J Urban, Ugarte Fornell LG, A Tzouvelekis, K Twohig, A Turner, S. Trujillo, A Triani, D Traila, V Torres, H Tomioka, K Tomii, R Tomic, C Toma, Akyil F Tokgoz, K Tobino, R Tobar, A Tiwari, R Tibana, X Tian, M Thillai, W Tham, F Teo, Trkanjec J Tekavec, P Teixeira, D Tarpey, L Tapias, K Tanizawa, Y Tanino, T Takada, G Tabaj, E Szolnoki, R Swarnakar, I Strambu, M Sterclova, K Spinks, Soo CI, A Soltani, S Solanki, E Sobh, Soares MR, J Smith, B Smith, P Slocum, H Slabbynck, I Sivokozov, A Shifren, Shen SM, C Sharp, A Shanmuganathan, A Sebastiani, S Scarlata, R Savas, S Sasaki, J Santeliz, Santana ANC, R Sanchez, M Salinas, S Saito, F Ryan, Royo Prats JA, E Rosi, H Rokadia, Perez A Robles, Ortega P Rivera, Ramirez M Rio, S Righetti, C Reichner, C Ravaglia, P Ratanawatkul, V Ramalingam, A Rajasekaran, E Radzikowska, Ra SW, S Quadrelli, J Precerutti, J Prasad, D Popa, S Pizzalato, W Piotrowski, A Pineiro, D Piloni, Golubicic T Peros, R Perez, C Pereira, B Pereira, M Perch, N Patel, D Patel, I Papanikolaou, D Papakosta, E Panselinas, Pang YK, P Pandya, E Padrao, Kumbasar O Ozdemir, Overbeek MJ, Minasian A Otto, D O'Riordan, J Ora, J Oldham, O Okutan, S Ohshimo, Oguzulgen IK, T Ogura, T O'Donnell, C O'Dochartaigh, S O'Beirne, L Novikova, L Novelli, I Noth, Mendes Neto N Nogueira, M Niroumand, A Nieto, A Neves, A Nambiar, S Nair, R Nadama, E Murtagh, M Mura, Quernheim J Muller, A Mukhopadhyay, S Mukherjee, J Morisset, O Moran, J Mooney, J Moller, N Mogulkoc, A Miyamoto, B Milenkovic, S Mette, M Mejia, F Mei, M Mazzei, T Matsuda, C Mason, Frances M Martinez, S Mannarino, E Mancuzo, F Malli, P Malhotra, M Maillo, J Maia, M Mahdavian, F Madsen, T Luckhardt, W Lucht, Low SY, Lopez Miguel CP, R Lipchik, S Levy, K Levin, Lee KL, D Lederer, Lammi MR, Kwan HY, S Kukreja, A Kruavit, M Kotecki, L Kolilekas, H Knoop, E Kiyan, T Kishaba, Biggs M King, Khor YH, A Khan, N Khalil, R Kedia, N Kebba, Dourado L Kawano, K Kapitan, C. D Kan, A. F Kalyoncu, M Kalluri, Y Kabasakal, S Jyothula, Juretschke MA, D Jovanovic, R Jonkers, H Jo, S Izumi, H Ishii, S Ikeda, A Ibrahim, C Hyldgaard, G Hunninghake, T Huie, A Hufton, X Hu, W. C Hseih, R Hoyos, R Hoyles, Rodriguez O Holguin, M. P Hogan, U Hodgson, Sogoloff H Hilkin, E Herrera, B. M Henry, M Hellemons, A Hecimovic, R Hayashi, S Hart, S Harari, S Haney, N Hambly, R Hakkim, M Gutierrez, R Gripaldo, A Gomez, N Goh, R Godoy, C Gilbert, I Giannarakis, S Gasparini, P Garcha, S Furtado, A Fois, Page P Flood, S Fletcher, E Fiss, Casas J Figueroa, Casas M Figueroa, Fiddler CA, G Ferrara, Casares M Fernandez, C Felton, P Faverio, Fabro AT, A Estrada, P Errhalt, N Enomoto, Enghelmayer JI, Kersh K El, G Eiger, A Dubaniewicz, F Drakopanagiotakis, S Disayabutr, A Dijkstra, Diaz Patino JC, Diaz Castanon JJ, S Dhooria, Dhasmana DJ, Rosa M De, Luca S De, A Delobbe, D Delgado, C Delgado, La Fuente I De, Kruif M De, Gier M De, Andrade J De, Davidsen JR, B Daoud, K Dalhoff, Cotera Solano JV, Costa AN, S Coronel, M Confalonieri, L Conemans, A Comellas, S Colella, S Clemente, J Clark, M Ciuffreda, Chung CL, Chong SG, D Chirita, Chen PL, N Chaudhuri, D Chambers, G Chalmers, D Chairman, Chai GT, Chaves R Chacon, V Cetinsu, M Ceruti, Ceballos Zuniga CO, D Castillo, Carbone RG, A Caminati, Callejas Gonzalez FJ, M Butler, C Bustos, M Bukowczan, I Buendia, G Brunetti, B Brockway, P Bresser, J Breseghello, D Bouros, Botero Zaccour JA, G Borzone, R Borie, Blum HC, J Blank, A Biswas, D Bennett, M Benjamin, Belaconi IN, P Beirne, L Beckert, S Bastiampillai, R Bascom, B Bartholmai, M Barros, Ban AYL, E Balestro, B Baldi, Martinez J Baddini, A Baburao, S Babu, A Averyanov, S Avdeev, R Athanazio, E Atahan, B Asuquo, D Assayag, J Antuni, S Antillon, Anderson KC, A Anderson, F Alwani, G Altinisik, N Alsouofi, Allam JS, Jahdali H Al, Farttoosi A Al, T Alfaro, Busaidi N Al, Foumani A Alavi, Agreda Vedia MG, A Agarwal, F Afridi, Adeyeye OO, A Adegunsoye, H Adamali, A Abedini

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.

Lingua originale	Inglese
pagine (da-a)	1-10
Numero di pagine	10
Rivista	European Respiratory Journal
Volume	50
Numero di pubblicazione	2
DOI	https://doi.org/10.1183/13993003.00936-2017
Stato di pubblicazione	Pubblicato - 2017

All Science Journal Classification (ASJC) codes

Medicina Polmonare e Respiratoria

Keywords

Idiopathic Pulmonary Fibrosis

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Accesso al documento

10.1183/13993003.00936-2017

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SLF, W., TM, M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., ML, W., KM, A., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., TJ, C., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., ... Abedini, A. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study. European Respiratory Journal, 50(2), 1-10. https://doi.org/10.1183/13993003.00936-2017

@article{0d6fa944f2e2454ab61f04c712069150,

title = "Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study",

abstract = "We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.",

keywords = "Idiopathic Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis",

author = "Walsh SLF and Maher TM and M Kolb and V Poletti and R Nusser and Luca Richeldi and C Vancheri and Wilsher ML and Antoniou KM and J Behr and E Bendstrup and K Brown and L Calandriello and Corte TJ and V Cottin and B Crestani and K Flaherty and I Glaspole and J Grutters and Y Inoue and M Kokosi and Y Kondoh and V Kouranos and M Kreuter and K Johannson and E Judge and B Ley and G Margaritopoulos and Martinez FJ and M Molina-Molina and A Morais and H Nunes and G Raghu and Ryerson CJ and M Selman and P Spagnolo and H Taniguchi and S Tomassetti and D Valeyre and M Wijsenbeek and W Wuyts and D Hansell and A Wells and Zhu PS and Y Yuan and Yoshito, \{Fukuda C\} and Y Yoshimatsu and A Xaubet and Wong AM and P White and G Westney and A West and T Wessendorf and Y Waseda and C Wang and Vienna JM and Videnovic, \{Ivanov J\} and Vicens, \{Zygmunt V\} and MC, \{Venero Caceres\} and Velasquez, \{Pinto G\} and E Veitch and M Vasakova and F Varone and Varela BE and Van, \{Hal P\} and Van, \{De Ven M\} and Van, \{Der Lee I\} and Van, \{Den Toorn L\} and Urrutia, \{Gajate A\} and J Urban and LG, \{Ugarte Fornell\} and A Tzouvelekis and K Twohig and A Turner and S. Trujillo and A Triani and D Traila and V Torres and H Tomioka and K Tomii and R Tomic and C Toma and Tokgoz, \{Akyil F\} and K Tobino and R Tobar and A Tiwari and R Tibana and X Tian and M Thillai and W Tham and F Teo and Tekavec, \{Trkanjec J\} and P Teixeira and D Tarpey and L Tapias and K Tanizawa and Y Tanino and T Takada and G Tabaj and E Szolnoki and R Swarnakar and I Strambu and M Sterclova and K Spinks and Soo CI and A Soltani and S Solanki and E Sobh and Soares MR and J Smith and B Smith and P Slocum and H Slabbynck and I Sivokozov and A Shifren and Shen SM and C Sharp and A Shanmuganathan and A Sebastiani and S Scarlata and R Savas and S Sasaki and J Santeliz and Santana ANC and R Sanchez and M Salinas and S Saito and F Ryan and JA, \{Royo Prats\} and E Rosi and H Rokadia and Robles, \{Perez A\} and Rivera, \{Ortega P\} and Rio, \{Ramirez M\} and S Righetti and C Reichner and C Ravaglia and P Ratanawatkul and V Ramalingam and A Rajasekaran and E Radzikowska and Ra SW and S Quadrelli and J Precerutti and J Prasad and D Popa and S Pizzalato and W Piotrowski and A Pineiro and D Piloni and Peros, \{Golubicic T\} and R Perez and C Pereira and B Pereira and M Perch and N Patel and D Patel and I Papanikolaou and D Papakosta and E Panselinas and Pang YK and P Pandya and E Padrao and Ozdemir, \{Kumbasar O\} and Overbeek MJ and Otto, \{Minasian A\} and D O'Riordan and J Ora and J Oldham and O Okutan and S Ohshimo and Oguzulgen IK and T Ogura and T O'Donnell and C O'Dochartaigh and S O'Beirne and L Novikova and L Novelli and I Noth and Nogueira, \{Mendes Neto N\} and M Niroumand and A Nieto and A Neves and A Nambiar and S Nair and R Nadama and E Murtagh and M Mura and Muller, \{Quernheim J\} and A Mukhopadhyay and S Mukherjee and J Morisset and O Moran and J Mooney and J Moller and N Mogulkoc and A Miyamoto and B Milenkovic and S Mette and M Mejia and F Mei and M Mazzei and T Matsuda and C Mason and Martinez, \{Frances M\} and S Mannarino and E Mancuzo and F Malli and P Malhotra and M Maillo and J Maia and M Mahdavian and F Madsen and T Luckhardt and W Lucht and Low SY and CP, \{Lopez Miguel\} and R Lipchik and S Levy and K Levin and Lee KL and D Lederer and Lammi MR and Kwan HY and S Kukreja and A Kruavit and M Kotecki and L Kolilekas and H Knoop and E Kiyan and T Kishaba and King, \{Biggs M\} and Khor YH and A Khan and N Khalil and R Kedia and N Kebba and Kawano, \{Dourado L\} and K Kapitan and Kan, \{C. D\} and Kalyoncu, \{A. F\} and M Kalluri and Y Kabasakal and S Jyothula and Juretschke MA and D Jovanovic and R Jonkers and H Jo and S Izumi and H Ishii and S Ikeda and A Ibrahim and C Hyldgaard and G Hunninghake and T Huie and A Hufton and X Hu and Hseih, \{W. C\} and R Hoyos and R Hoyles and Holguin, \{Rodriguez O\} and Hogan, \{M. P\} and U Hodgson and Hilkin, \{Sogoloff H\} and E Herrera and Henry, \{B. M\} and M Hellemons and A Hecimovic and R Hayashi and S Hart and S Harari and S Haney and N Hambly and R Hakkim and M Gutierrez and R Gripaldo and A Gomez and N Goh and R Godoy and C Gilbert and I Giannarakis and S Gasparini and P Garcha and S Furtado and A Fois and Flood, \{Page P\} and S Fletcher and E Fiss and Figueroa, \{Casas J\} and Figueroa, \{Casas M\} and Fiddler CA and G Ferrara and Fernandez, \{Casares M\} and C Felton and P Faverio and Fabro AT and A Estrada and P Errhalt and N Enomoto and Enghelmayer JI and El, \{Kersh K\} and G Eiger and A Dubaniewicz and F Drakopanagiotakis and S Disayabutr and A Dijkstra and JC, \{Diaz Patino\} and JJ, \{Diaz Castanon\} and S Dhooria and Dhasmana DJ and De, \{Rosa M\} and De, \{Luca S\} and A Delobbe and D Delgado and C Delgado and De, \{La Fuente I\} and De, \{Kruif M\} and De, \{Gier M\} and De, \{Andrade J\} and Davidsen JR and B Daoud and K Dalhoff and JV, \{Cotera Solano\} and Costa AN and S Coronel and M Confalonieri and L Conemans and A Comellas and S Colella and S Clemente and J Clark and M Ciuffreda and Chung CL and Chong SG and D Chirita and Chen PL and N Chaudhuri and D Chambers and G Chalmers and D Chairman and Chai GT and Chacon, \{Chaves R\} and V Cetinsu and M Ceruti and CO, \{Ceballos Zuniga\} and D Castillo and Carbone RG and A Caminati and FJ, \{Callejas Gonzalez\} and M Butler and C Bustos and M Bukowczan and I Buendia and G Brunetti and B Brockway and P Bresser and J Breseghello and D Bouros and JA, \{Botero Zaccour\} and G Borzone and R Borie and Blum HC and J Blank and A Biswas and D Bennett and M Benjamin and Belaconi IN and P Beirne and L Beckert and S Bastiampillai and R Bascom and B Bartholmai and M Barros and Ban AYL and E Balestro and B Baldi and Baddini, \{Martinez J\} and A Baburao and S Babu and A Averyanov and S Avdeev and R Athanazio and E Atahan and B Asuquo and D Assayag and J Antuni and S Antillon and Anderson KC and A Anderson and F Alwani and G Altinisik and N Alsouofi and Allam JS and Al, \{Jahdali H\} and Al, \{Farttoosi A\} and T Alfaro and Al, \{Busaidi N\} and Alavi, \{Foumani A\} and MG, \{Agreda Vedia\} and A Agarwal and F Afridi and Adeyeye OO and A Adegunsoye and H Adamali and A Abedini",

year = "2017",

doi = "10.1183/13993003.00936-2017",

language = "English",

volume = "50",

pages = "1--10",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "2",

}

SLF, W, TM, M, Kolb, M, Poletti, V, Nusser, R, Richeldi, L, Vancheri, C, ML, W, KM, A, Behr, J, Bendstrup, E, Brown, K, Calandriello, L, TJ, C, Cottin, V, Crestani, B, Flaherty, K, Glaspole, I, Grutters, J, Inoue, Y, Kokosi, M, Kondoh, Y, Kouranos, V, Kreuter, M, Johannson, K, Judge, E, Ley, B, Margaritopoulos, G, FJ, M, Molina-Molina, M, Morais, A, Nunes, H, Raghu, G, CJ, R, Selman, M, Spagnolo, P, Taniguchi, H, Tomassetti, S, Valeyre, D, Wijsenbeek, M, Wuyts, W, Hansell, D, Wells, A, PS, Z, Yuan, Y, Yoshito, FC, Yoshimatsu, Y, Xaubet, A, AM, W, White, P, Westney, G, West, A, Wessendorf, T, Waseda, Y, Wang, C, JM, V, Videnovic, IJ, Vicens, ZV, MC, VC, Velasquez, PG, Veitch, E, Vasakova, M, Varone, F, BE, V, Van, HP, Van, DVM, Van, DLI, Van, DTL, Urrutia, GA, Urban, J, LG, UF, Tzouvelekis, A, Twohig, K, Turner, A, Trujillo, S, Triani, A, Traila, D, Torres, V, Tomioka, H, Tomii, K, Tomic, R, Toma, C, Tokgoz, AF, Tobino, K, Tobar, R, Tiwari, A, Tibana, R, Tian, X, Thillai, M, Tham, W, Teo, F, Tekavec, TJ, Teixeira, P, Tarpey, D, Tapias, L, Tanizawa, K, Tanino, Y, Takada, T, Tabaj, G, Szolnoki, E, Swarnakar, R, Strambu, I, Sterclova, M, Spinks, K, CI, S, Soltani, A, Solanki, S, Sobh, E, MR, S, Smith, J, Smith, B, Slocum, P, Slabbynck, H, Sivokozov, I, Shifren, A, SM, S, Sharp, C, Shanmuganathan, A, Sebastiani, A, Scarlata, S, Savas, R, Sasaki, S, Santeliz, J, ANC, S, Sanchez, R, Salinas, M, Saito, S, Ryan, F, JA, RP, Rosi, E, Rokadia, H, Robles, PA, Rivera, OP, Rio, RM, Righetti, S, Reichner, C, Ravaglia, C, Ratanawatkul, P, Ramalingam, V, Rajasekaran, A, Radzikowska, E, SW, R, Quadrelli, S, Precerutti, J, Prasad, J, Popa, D, Pizzalato, S, Piotrowski, W, Pineiro, A, Piloni, D, Peros, GT, Perez, R, Pereira, C, Pereira, B, Perch, M, Patel, N, Patel, D, Papanikolaou, I, Papakosta, D, Panselinas, E, YK, P, Pandya, P, Padrao, E, Ozdemir, KO, MJ, O, Otto, MA, O'Riordan, D, Ora, J, Oldham, J, Okutan, O, Ohshimo, S, IK, O, Ogura, T, O'Donnell, T, O'Dochartaigh, C, O'Beirne, S, Novikova, L, Novelli, L, Noth, I, Nogueira, MNN, Niroumand, M, Nieto, A, Neves, A, Nambiar, A, Nair, S, Nadama, R, Murtagh, E, Mura, M, Muller, QJ, Mukhopadhyay, A, Mukherjee, S, Morisset, J, Moran, O, Mooney, J, Moller, J, Mogulkoc, N, Miyamoto, A, Milenkovic, B, Mette, S, Mejia, M, Mei, F, Mazzei, M, Matsuda, T, Mason, C, Martinez, FM, Mannarino, S, Mancuzo, E, Malli, F, Malhotra, P, Maillo, M, Maia, J, Mahdavian, M, Madsen, F, Luckhardt, T, Lucht, W, SY, L, CP, LM, Lipchik, R, Levy, S, Levin, K, KL, L, Lederer, D, MR, L, HY, K, Kukreja, S, Kruavit, A, Kotecki, M, Kolilekas, L, Knoop, H, Kiyan, E, Kishaba, T, King, BM, YH, K, Khan, A, Khalil, N, Kedia, R, Kebba, N, Kawano, DL, Kapitan, K, Kan, CD, Kalyoncu, AF, Kalluri, M, Kabasakal, Y, Jyothula, S, MA, J, Jovanovic, D, Jonkers, R, Jo, H, Izumi, S, Ishii, H, Ikeda, S, Ibrahim, A, Hyldgaard, C, Hunninghake, G, Huie, T, Hufton, A, Hu, X, Hseih, WC, Hoyos, R, Hoyles, R, Holguin, RO, Hogan, MP, Hodgson, U, Hilkin, SH, Herrera, E, Henry, BM, Hellemons, M, Hecimovic, A, Hayashi, R, Hart, S, Harari, S, Haney, S, Hambly, N, Hakkim, R, Gutierrez, M, Gripaldo, R, Gomez, A, Goh, N, Godoy, R, Gilbert, C, Giannarakis, I, Gasparini, S, Garcha, P, Furtado, S, Fois, A, Flood, PP, Fletcher, S, Fiss, E, Figueroa, CJ, Figueroa, CM, CA, F, Ferrara, G, Fernandez, CM, Felton, C, Faverio, P, AT, F, Estrada, A, Errhalt, P, Enomoto, N, JI, E, El, KK, Eiger, G, Dubaniewicz, A, Drakopanagiotakis, F, Disayabutr, S, Dijkstra, A, JC, DP, JJ, DC, Dhooria, S, DJ, D, De, RM, De, LS, Delobbe, A, Delgado, D, Delgado, C, De, LFI, De, KM, De, GM, De, AJ, JR, D, Daoud, B, Dalhoff, K, JV, CS, AN, C, Coronel, S, Confalonieri, M, Conemans, L, Comellas, A, Colella, S, Clemente, S, Clark, J, Ciuffreda, M, CL, C, SG, C, Chirita, D, PL, C, Chaudhuri, N, Chambers, D, Chalmers, G, Chairman, D, GT, C, Chacon, CR, Cetinsu, V, Ceruti, M, CO, CZ, Castillo, D, RG, C, Caminati, A, FJ, CG, Butler, M, Bustos, C, Bukowczan, M, Buendia, I, Brunetti, G, Brockway, B, Bresser, P, Breseghello, J, Bouros, D, JA, BZ, Borzone, G, Borie, R, HC, B, Blank, J, Biswas, A, Bennett, D, Benjamin, M, IN, B, Beirne, P, Beckert, L, Bastiampillai, S, Bascom, R, Bartholmai, B, Barros, M, AYL, B, Balestro, E, Baldi, B, Baddini, MJ, Baburao, A, Babu, S, Averyanov, A, Avdeev, S, Athanazio, R, Atahan, E, Asuquo, B, Assayag, D, Antuni, J, Antillon, S, KC, A, Anderson, A, Alwani, F, Altinisik, G, Alsouofi, N, JS, A, Al, JH, Al, FA, Alfaro, T, Al, BN, Alavi, FA, MG, AV, Agarwal, A, Afridi, F, OO, A, Adegunsoye, A, Adamali, H & Abedini, A 2017, 'Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study', European Respiratory Journal, vol. 50, n. 2, pagg. 1-10. https://doi.org/10.1183/13993003.00936-2017

TY - JOUR

T1 - Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

AU - SLF, Walsh

AU - TM, Maher

AU - Kolb, M

AU - Poletti, V

AU - Nusser, R

AU - Richeldi, Luca

AU - Vancheri, C

AU - ML, Wilsher

AU - KM, Antoniou

AU - Behr, J

AU - Bendstrup, E

AU - Brown, K

AU - Calandriello, L

AU - TJ, Corte

AU - Cottin, V

AU - Crestani, B

AU - Flaherty, K

AU - Glaspole, I

AU - Grutters, J

AU - Inoue, Y

AU - Kokosi, M

AU - Kondoh, Y

AU - Kouranos, V

AU - Kreuter, M

AU - Johannson, K

AU - Judge, E

AU - Ley, B

AU - Margaritopoulos, G

AU - FJ, Martinez

AU - Molina-Molina, M

AU - Morais, A

AU - Nunes, H

AU - Raghu, G

AU - CJ, Ryerson

AU - Selman, M

AU - Spagnolo, P

AU - Taniguchi, H

AU - Tomassetti, S

AU - Valeyre, D

AU - Wijsenbeek, M

AU - Wuyts, W

AU - Hansell, D

AU - Wells, A

AU - PS, Zhu

AU - Yuan, Y

AU - Yoshito, Fukuda C

AU - Yoshimatsu, Y

AU - Xaubet, A

AU - AM, Wong

AU - White, P

AU - Westney, G

AU - West, A

AU - Wessendorf, T

AU - Waseda, Y

AU - Wang, C

AU - JM, Vienna

AU - Videnovic, Ivanov J

AU - Vicens, Zygmunt V

AU - MC, Venero Caceres

AU - Velasquez, Pinto G

AU - Veitch, E

AU - Vasakova, M

AU - Varone, F

AU - BE, Varela

AU - Van, Hal P

AU - Van, De Ven M

AU - Van, Der Lee I

AU - Van, Den Toorn L

AU - Urrutia, Gajate A

AU - Urban, J

AU - LG, Ugarte Fornell

AU - Tzouvelekis, A

AU - Twohig, K

AU - Turner, A

AU - Trujillo, S.

AU - Triani, A

AU - Traila, D

AU - Torres, V

AU - Tomioka, H

AU - Tomii, K

AU - Tomic, R

AU - Toma, C

AU - Tokgoz, Akyil F

AU - Tobino, K

AU - Tobar, R

AU - Tiwari, A

AU - Tibana, R

AU - Tian, X

AU - Thillai, M

AU - Tham, W

AU - Teo, F

AU - Tekavec, Trkanjec J

AU - Teixeira, P

AU - Tarpey, D

AU - Tapias, L

AU - Tanizawa, K

AU - Tanino, Y

AU - Takada, T

AU - Tabaj, G

AU - Szolnoki, E

AU - Swarnakar, R

AU - Strambu, I

AU - Sterclova, M

AU - Spinks, K

AU - CI, Soo

AU - Soltani, A

AU - Solanki, S

AU - Sobh, E

AU - MR, Soares

AU - Smith, J

AU - Smith, B

AU - Slocum, P

AU - Slabbynck, H

AU - Sivokozov, I

AU - Shifren, A

AU - SM, Shen

AU - Sharp, C

AU - Shanmuganathan, A

AU - Sebastiani, A

AU - Scarlata, S

AU - Savas, R

AU - Sasaki, S

AU - Santeliz, J

AU - ANC, Santana

AU - Sanchez, R

AU - Salinas, M

AU - Saito, S

AU - Ryan, F

AU - JA, Royo Prats

AU - Rosi, E

AU - Rokadia, H

AU - Robles, Perez A

AU - Rivera, Ortega P

AU - Rio, Ramirez M

AU - Righetti, S

AU - Reichner, C

AU - Ravaglia, C

AU - Ratanawatkul, P

AU - Ramalingam, V

AU - Rajasekaran, A

AU - Radzikowska, E

AU - SW, Ra

AU - Quadrelli, S

AU - Precerutti, J

AU - Prasad, J

AU - Popa, D

AU - Pizzalato, S

AU - Piotrowski, W

AU - Pineiro, A

AU - Piloni, D

AU - Peros, Golubicic T

AU - Perez, R

AU - Pereira, C

AU - Pereira, B

AU - Perch, M

AU - Patel, N

AU - Patel, D

AU - Papanikolaou, I

AU - Papakosta, D

AU - Panselinas, E

AU - YK, Pang

AU - Pandya, P

AU - Padrao, E

AU - Ozdemir, Kumbasar O

AU - MJ, Overbeek

AU - Otto, Minasian A

AU - O'Riordan, D

AU - Ora, J

AU - Oldham, J

AU - Okutan, O

AU - Ohshimo, S

AU - IK, Oguzulgen

AU - Ogura, T

AU - O'Donnell, T

AU - O'Dochartaigh, C

AU - O'Beirne, S

AU - Novikova, L

AU - Novelli, L

AU - Noth, I

AU - Nogueira, Mendes Neto N

AU - Niroumand, M

AU - Nieto, A

AU - Neves, A

AU - Nambiar, A

AU - Nair, S

AU - Nadama, R

AU - Murtagh, E

AU - Mura, M

AU - Muller, Quernheim J

AU - Mukhopadhyay, A

AU - Mukherjee, S

AU - Morisset, J

AU - Moran, O

AU - Mooney, J

AU - Moller, J

AU - Mogulkoc, N

AU - Miyamoto, A

AU - Milenkovic, B

AU - Mette, S

AU - Mejia, M

AU - Mei, F

AU - Mazzei, M

AU - Matsuda, T

AU - Mason, C

AU - Martinez, Frances M

AU - Mannarino, S

AU - Mancuzo, E

AU - Malli, F

AU - Malhotra, P

AU - Maillo, M

AU - Maia, J

AU - Mahdavian, M

AU - Madsen, F

AU - Luckhardt, T

AU - Lucht, W

AU - SY, Low

AU - CP, Lopez Miguel

AU - Lipchik, R

AU - Levy, S

AU - Levin, K

AU - KL, Lee

AU - Lederer, D

AU - MR, Lammi

AU - HY, Kwan

AU - Kukreja, S

AU - Kruavit, A

AU - Kotecki, M

AU - Kolilekas, L

AU - Knoop, H

AU - Kiyan, E

AU - Kishaba, T

AU - King, Biggs M

AU - YH, Khor

AU - Khan, A

AU - Khalil, N

AU - Kedia, R

AU - Kebba, N

AU - Kawano, Dourado L

AU - Kapitan, K

AU - Kan, C. D

AU - Kalyoncu, A. F

AU - Kalluri, M

AU - Kabasakal, Y

AU - Jyothula, S

AU - MA, Juretschke

AU - Jovanovic, D

AU - Jonkers, R

AU - Jo, H

AU - Izumi, S

AU - Ishii, H

AU - Ikeda, S

AU - Ibrahim, A

AU - Hyldgaard, C

AU - Hunninghake, G

AU - Huie, T

AU - Hufton, A

AU - Hu, X

AU - Hseih, W. C

AU - Hoyos, R

AU - Hoyles, R

AU - Holguin, Rodriguez O

AU - Hogan, M. P

AU - Hodgson, U

AU - Hilkin, Sogoloff H

AU - Herrera, E

AU - Henry, B. M

AU - Hellemons, M

AU - Hecimovic, A

AU - Hayashi, R

AU - Hart, S

AU - Harari, S

AU - Haney, S

AU - Hambly, N

AU - Hakkim, R

AU - Gutierrez, M

AU - Gripaldo, R

AU - Gomez, A

AU - Goh, N

AU - Godoy, R

AU - Gilbert, C

AU - Giannarakis, I

AU - Gasparini, S

AU - Garcha, P

AU - Furtado, S

AU - Fois, A

AU - Flood, Page P

AU - Fletcher, S

AU - Fiss, E

AU - Figueroa, Casas J

AU - Figueroa, Casas M

AU - CA, Fiddler

AU - Ferrara, G

AU - Fernandez, Casares M

AU - Felton, C

AU - Faverio, P

AU - AT, Fabro

AU - Estrada, A

AU - Errhalt, P

AU - Enomoto, N

AU - JI, Enghelmayer

AU - El, Kersh K

AU - Eiger, G

AU - Dubaniewicz, A

AU - Drakopanagiotakis, F

AU - Disayabutr, S

AU - Dijkstra, A

AU - JC, Diaz Patino

AU - JJ, Diaz Castanon

AU - Dhooria, S

AU - DJ, Dhasmana

AU - De, Rosa M

AU - De, Luca S

AU - Delobbe, A

AU - Delgado, D

AU - Delgado, C

AU - De, La Fuente I

AU - De, Kruif M

AU - De, Gier M

AU - De, Andrade J

AU - JR, Davidsen

AU - Daoud, B

AU - Dalhoff, K

AU - JV, Cotera Solano

AU - AN, Costa

AU - Coronel, S

AU - Confalonieri, M

AU - Conemans, L

AU - Comellas, A

AU - Colella, S

AU - Clemente, S

AU - Clark, J

AU - Ciuffreda, M

AU - CL, Chung

AU - SG, Chong

AU - Chirita, D

AU - PL, Chen

AU - Chaudhuri, N

AU - Chambers, D

AU - Chalmers, G

AU - Chairman, D

AU - GT, Chai

AU - Chacon, Chaves R

AU - Cetinsu, V

AU - Ceruti, M

AU - CO, Ceballos Zuniga

AU - Castillo, D

AU - RG, Carbone

AU - Caminati, A

AU - FJ, Callejas Gonzalez

AU - Butler, M

AU - Bustos, C

AU - Bukowczan, M

AU - Buendia, I

AU - Brunetti, G

AU - Brockway, B

AU - Bresser, P

AU - Breseghello, J

AU - Bouros, D

AU - JA, Botero Zaccour

AU - Borzone, G

AU - Borie, R

AU - HC, Blum

AU - Blank, J

AU - Biswas, A

AU - Bennett, D

AU - Benjamin, M

AU - IN, Belaconi

AU - Beirne, P

AU - Beckert, L

AU - Bastiampillai, S

AU - Bascom, R

AU - Bartholmai, B

AU - Barros, M

AU - AYL, Ban

AU - Balestro, E

AU - Baldi, B

AU - Baddini, Martinez J

AU - Baburao, A

AU - Babu, S

AU - Averyanov, A

AU - Avdeev, S

AU - Athanazio, R

AU - Atahan, E

AU - Asuquo, B

AU - Assayag, D

AU - Antuni, J

AU - Antillon, S

AU - KC, Anderson

AU - Anderson, A

AU - Alwani, F

AU - Altinisik, G

AU - Alsouofi, N

AU - JS, Allam

AU - Al, Jahdali H

AU - Al, Farttoosi A

AU - Alfaro, T

AU - Al, Busaidi N

AU - Alavi, Foumani A

AU - MG, Agreda Vedia

AU - Agarwal, A

AU - Afridi, F

AU - OO, Adeyeye

AU - Adegunsoye, A

AU - Adamali, H

AU - Abedini, A

PY - 2017

Y1 - 2017

N2 - We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.

AB - We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.

KW - Idiopathic Pulmonary Fibrosis

UR - https://publicatt.unicatt.it/handle/10807/324156

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85023612291&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85023612291&origin=inward

U2 - 10.1183/13993003.00936-2017

DO - 10.1183/13993003.00936-2017

M3 - Article

SN - 0903-1936

VL - 50

SP - 1

EP - 10

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 2

ER -

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

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