TY - JOUR
T1 - Diabetic lung, an underrated complication from restrictive functional pattern to pulmonary hypertension
AU - Pitocco, Dario
AU - Fuso, Leonello
AU - Antonelli-Incalzi, Raffaele
PY - 2019
Y1 - 2019
N2 - In patients with type 1 and type 2 diabetes mellitus (DM), respiratory function abnormalities have been reported with regard to lung volumes, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Indeed, the decrease in lung volumes and the impairment of diffusing capacity might have important clinical implications. Furthermore, there is an increasing evidence of a link between DM and pulmonary hypertension (PH) related to an involvement of the pulmonary vascular structures. These findings support the view of the lung as target organ in DM. In this paper, we briefly describe the main derangements of the respiratory system in DM and the inherent mechanisms.
AB - In patients with type 1 and type 2 diabetes mellitus (DM), respiratory function abnormalities have been reported with regard to lung volumes, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Indeed, the decrease in lung volumes and the impairment of diffusing capacity might have important clinical implications. Furthermore, there is an increasing evidence of a link between DM and pulmonary hypertension (PH) related to an involvement of the pulmonary vascular structures. These findings support the view of the lung as target organ in DM. In this paper, we briefly describe the main derangements of the respiratory system in DM and the inherent mechanisms.
KW - diabetic microangiopathy
KW - pulmonary hypertension
KW - respiratory function
KW - diabetic microangiopathy
KW - pulmonary hypertension
KW - respiratory function
UR - http://hdl.handle.net/10807/148473
U2 - 10.1002/dmrr.3159
DO - 10.1002/dmrr.3159
M3 - Article
VL - 35
SP - N/A-N/A
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
SN - 1520-7552
ER -