Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies

Giovanni Delogu, Sandra Clarizio, S Gemma, L Savini, M Altarelli, P Tripaldi, L Chiasserini, Ss Coccone, V Kumar, C Camodeca, G Campiani, E Novellino, S. Butini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

48 Citazioni (Scopus)

Abstract

A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25microg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
Lingua originaleEnglish
pagine (da-a)6063-6072
Numero di pagine10
RivistaBIOORGANIC & MEDICINAL CHEMISTRY
Volume17
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Animals
  • Antitubercular Agents
  • Cell Line
  • Cercopithecus aethiops
  • Hydrazones
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis
  • Structure-Activity Relationship
  • Vero Cells

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