TY - JOUR
T1 - Development of a sensing array for human breath analysis based on SWCNT layers functionalized with semiconductor organic molecules
AU - Freddi, Sonia
AU - Emelianov, Aleksei V.
AU - Bobrinetskiy, Ivan I.
AU - Drera, Giovanni
AU - Pagliara, Stefania
AU - Kopylova, Daria S.
AU - Chiesa, Maria
AU - Santini, Giuseppe
AU - Mores, Nadia
AU - Moscato, Umberto
AU - Nasibulin, Albert G.
AU - Montuschi, Paolo
AU - Sangaletti, Luigi Ermenegildo
PY - 2020
Y1 - 2020
N2 - A sensor array based on heterojunctions between semiconducting organic layers and single walled carbon nanotubes (SWCNT) films is produced to explore applications in breathomics, the molecular analysis of exhaled breath. The array is exposed to gas/volatiles relevant to specific diseases (ammonia, ethanol, acetone, 2-propanol, sodium hypochlorite, benzene, hydrogen sulfide, and nitrogen dioxide). Then, to evaluate its capability to operate with real relevant biological samples the array is exposed to human breath exhaled from healthy subjects. Finally, to provide a proof of concept of its diagnostic potential, the array is exposed to exhaled breath samples collected from subjects with chronic obstructive pulmonary disease (COPD), an airway chronic inflammatory disease not yet investigated with CNT-based sensor arrays, and the results are compared to those from healthy subjects breathprints. Principal component analysis shows that the sensor array is able to detect various target gas/volatiles with a clear fingerprint on a 2D subspace, is suitable for breath profiling in exhaled human breath, and is able to distinguish subjects with COPD from healthy subjects based on their breathprints. The classification ability is further improved by selecting the most responsive sensors to nitrogen dioxide, which is proposed as a biomarker of COPD
AB - A sensor array based on heterojunctions between semiconducting organic layers and single walled carbon nanotubes (SWCNT) films is produced to explore applications in breathomics, the molecular analysis of exhaled breath. The array is exposed to gas/volatiles relevant to specific diseases (ammonia, ethanol, acetone, 2-propanol, sodium hypochlorite, benzene, hydrogen sulfide, and nitrogen dioxide). Then, to evaluate its capability to operate with real relevant biological samples the array is exposed to human breath exhaled from healthy subjects. Finally, to provide a proof of concept of its diagnostic potential, the array is exposed to exhaled breath samples collected from subjects with chronic obstructive pulmonary disease (COPD), an airway chronic inflammatory disease not yet investigated with CNT-based sensor arrays, and the results are compared to those from healthy subjects breathprints. Principal component analysis shows that the sensor array is able to detect various target gas/volatiles with a clear fingerprint on a 2D subspace, is suitable for breath profiling in exhaled human breath, and is able to distinguish subjects with COPD from healthy subjects based on their breathprints. The classification ability is further improved by selecting the most responsive sensors to nitrogen dioxide, which is proposed as a biomarker of COPD
KW - breathomics
KW - carbon nanotubes
KW - chronic obstructive pulmonary disease (COPD)
KW - electronic noses
KW - hybrid heterojunctions
KW - breathomics
KW - carbon nanotubes
KW - chronic obstructive pulmonary disease (COPD)
KW - electronic noses
KW - hybrid heterojunctions
UR - http://hdl.handle.net/10807/152756
U2 - 10.1002/adhm.202000377
DO - 10.1002/adhm.202000377
M3 - Article
SN - 2192-2659
SP - N/A-N/A
JO - Advanced healthcare materials
JF - Advanced healthcare materials
ER -