TY - JOUR
T1 - Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome: an OMERACT reliability exercise
AU - Hočevar, Alojzija
AU - Bruyn, George A.
AU - Terslev, Lene
AU - De Agustin, Juan Jose
AU - Maccarter, Daryl
AU - Chrysidis, Stavros
AU - Collado, Paz
AU - Dejaco, Christian
AU - Fana, Viktoria
AU - Filippou, Georgios
AU - Finzel, Stephanie
AU - Gandjbakhch, Frederique
AU - Hanova, Petra
AU - Hammenfors, Daniel
AU - Hernandez-Diaz, Cristina
AU - Iagnocco, Annamaria
AU - Mortada, Mohamed Atia
AU - Inanc, Nevsun
AU - Naredo, Esperanza
AU - Ohrndorf, Sarah
AU - Perko, Nejc
AU - Schmidt, Wolfgang A.
AU - Tamborrini, Giorgio
AU - Tomšič, Matija
AU - Chary-Valckenaere, Isabelle
AU - Zabotti, Alen
AU - Keen, Helen I.
AU - Pineda, Carlos
AU - D'Agostino, Maria Antonietta
AU - Jousse-Joulin, Sandrine
PY - 2021
Y1 - 2021
N2 - Objective: The aim of this exercise from the OMERACT ultrasound subgroup on Sjögren's syndrome (pSS) was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler (CD) ultrasound scoring system for pathologic salivary gland vascularization in patients with pSS.
Methods: Using the Delphi method a CD semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light's kappa (κ) analysis, respectively.
Results: The consensus-based semiquantitative score was: Grade 0, no visible vascular signals; Grade 1, focal, dispersed vascular signals; Grade 2, diffuse vascular signals detected in < 50% of the gland; Grade 3, diffuse vascular signals in > 50% of the gland. In static images, the intra- and inter-reader reliability showed excellent κ values (95% confidence interval) = 0.90 (0.87-0.93) and 0.80 (0.74-0.84), respectively) for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was κ = 0.84 (0.73-0.92) and 0.70 (0.64-0.76), respectively.
Conclusion: The consensus-based CD ultrasound scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings.
Keywords: colour Doppler ultrasound; primary Sjögren’s syndrome; salivary gland vascularization; scoring system.
AB - Objective: The aim of this exercise from the OMERACT ultrasound subgroup on Sjögren's syndrome (pSS) was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler (CD) ultrasound scoring system for pathologic salivary gland vascularization in patients with pSS.
Methods: Using the Delphi method a CD semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light's kappa (κ) analysis, respectively.
Results: The consensus-based semiquantitative score was: Grade 0, no visible vascular signals; Grade 1, focal, dispersed vascular signals; Grade 2, diffuse vascular signals detected in < 50% of the gland; Grade 3, diffuse vascular signals in > 50% of the gland. In static images, the intra- and inter-reader reliability showed excellent κ values (95% confidence interval) = 0.90 (0.87-0.93) and 0.80 (0.74-0.84), respectively) for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was κ = 0.84 (0.73-0.92) and 0.70 (0.64-0.76), respectively.
Conclusion: The consensus-based CD ultrasound scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings.
Keywords: colour Doppler ultrasound; primary Sjögren’s syndrome; salivary gland vascularization; scoring system.
KW - colour Doppler ultrasound
KW - primary Sjögren’s syndrome
KW - salivary gland vascularization
KW - scoring system
KW - colour Doppler ultrasound
KW - primary Sjögren’s syndrome
KW - salivary gland vascularization
KW - scoring system
UR - http://hdl.handle.net/10807/198141
U2 - 10.1093/rheumatology/keab876
DO - 10.1093/rheumatology/keab876
M3 - Article
SN - 1462-0324
SP - N/A-N/A
JO - Rheumatology
JF - Rheumatology
ER -