Background: Peach gibberellin-regulated protein (peamaclein) has recently emerged as a relevant food
allergen in cypress pollen-hypersensitive patients.
Objective: We looked for mono-sensitization to peamaclein among Italian cypress-pollen allergic patients.
Material and methods: 835 cypress pollen hypersensitive patients from 28 Italian allergy centers under
went thorough interview for food-allergic reactions, and SPT with a commercial peach extracts containing
peamaclein. In peach reactors, IgE to rPru p 3 was measured, and those scoring negative were enrolled as
potentially mono-sensitized to peamaclein. IgE reactivity to rPru p 7 was evaluated by immunoblot and by
an experimental ImmunoCAP with rPru p 7.
Results: Peach SPT scored positive in 163 (19.5%) patients but 127 (77,9%) were excluded because Pru p 3
reactors. Twenty-four (14,7%, corresponding to 2.8% of the entire study population) were considered as
potentially mono-sensitized to peamaclein. Their distribution did not show any geographic preference.
Seventeen/24 (70,8%) had a history of food allergy, in most cases (n=15) to peach. Other offending foods
included other Rosaceae, citrus fruits, fig, melon, tree nuts, and kiwi. On peach immunoblot, only 3/18
putative peamaclein allergic subjects reacted to a band at about 7kDa; 4 other patients reacted at about
50-60 kDa. Ten/18 (56%) scored positive for Pru p 7 on ImmunoCAP.
Conclusion: Peamaclein allergy and sensitization prevalence seem rare in Italy. Most patients react to
peach, albeit other Rosaceae fruits and several citrus fruits may also act as offending foods. Peach and
cypress pollen probably share also cross-reacting allergens other than peamaclein.
- Cypress pollen allergy
- Food allergy
- Pollen food syndrome