Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Mcf Prosperi; N Mackie; Simona Di Giambenedetto; M Zazzi; R Camacho; Iuri Fanti; C Torti; A Sönnerborg; R Kaiser; Fm Codoñer; K Van Laethem; L Bansi; Damc Van De Vijver; Am Geretti; Andrea De Luca

doi:10.1093/jac/dkr171

Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Mcf Prosperi, N Mackie, Simona Di Giambenedetto, M Zazzi, R Camacho, Iuri Fanti, C Torti, A Sönnerborg, R Kaiser, Fm Codoñer, K Van Laethem, L Bansi, Damc Van De Vijver, Am Geretti, Andrea De Luca

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34 Citazioni (Scopus)

Abstract

Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.

Lingua originale	English
pagine (da-a)	1886-1896
Numero di pagine	11
Rivista	Journal of Antimicrobial Chemotherapy
Volume	66
DOI	https://doi.org/10.1093/jac/dkr171
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adult
Anti-HIV Agents
CD4 Lymphocyte Count
Cohort Studies
Drug Resistance, Viral
Europe
Female
Genotype
HIV Infections
HIV-1
Humans
Male
Mutation, Missense
RNA, Viral
Viral Load
Viral Proteins

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Prosperi, M., Mackie, N., Di Giambenedetto, S., Zazzi, M., Camacho, R., Fanti, I., Torti, C., Sönnerborg, A., Kaiser, R., Codoñer, F., Van Laethem, K., Bansi, L., Van De Vijver, D., Geretti, A., & De Luca, A. (2011). Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study. Journal of Antimicrobial Chemotherapy, 66, 1886-1896. https://doi.org/10.1093/jac/dkr171

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title = "Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study",

abstract = "Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.",

keywords = "Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Cohort Studies, Drug Resistance, Viral, Europe, Female, Genotype, HIV Infections, HIV-1, Humans, Male, Mutation, Missense, RNA, Viral, Viral Load, Viral Proteins, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Cohort Studies, Drug Resistance, Viral, Europe, Female, Genotype, HIV Infections, HIV-1, Humans, Male, Mutation, Missense, RNA, Viral, Viral Load, Viral Proteins",

author = "Mcf Prosperi and N Mackie and {Di Giambenedetto}, Simona and M Zazzi and R Camacho and Iuri Fanti and C Torti and A S{\"o}nnerborg and R Kaiser and Fm Codo{\~n}er and {Van Laethem}, K and L Bansi and {Van De Vijver}, Damc and Am Geretti and {De Luca}, Andrea",

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doi = "10.1093/jac/dkr171",

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Prosperi, M, Mackie, N, Di Giambenedetto, S, Zazzi, M, Camacho, R, Fanti, I, Torti, C, Sönnerborg, A, Kaiser, R, Codoñer, F, Van Laethem, K, Bansi, L, Van De Vijver, D, Geretti, A & De Luca, A 2011, 'Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study', Journal of Antimicrobial Chemotherapy, vol. 66, pagg. 1886-1896. https://doi.org/10.1093/jac/dkr171

TY - JOUR

T1 - Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

AU - Prosperi, Mcf

AU - Mackie, N

AU - Di Giambenedetto, Simona

AU - Zazzi, M

AU - Camacho, R

AU - Fanti, Iuri

AU - Torti, C

AU - Sönnerborg, A

AU - Kaiser, R

AU - Codoñer, Fm

AU - Van Laethem, K

AU - Bansi, L

AU - Van De Vijver, Damc

AU - Geretti, Am

AU - De Luca, Andrea

PY - 2011

Y1 - 2011

N2 - Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.

AB - Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.

KW - Adult

KW - Anti-HIV Agents

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Drug Resistance, Viral

KW - Europe

KW - Female

KW - Genotype

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Mutation, Missense

KW - RNA, Viral

KW - Viral Load

KW - Viral Proteins

KW - Adult

KW - Anti-HIV Agents

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Drug Resistance, Viral

KW - Europe

KW - Female

KW - Genotype

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Mutation, Missense

KW - RNA, Viral

KW - Viral Load

KW - Viral Proteins

UR - http://hdl.handle.net/10807/6356

U2 - 10.1093/jac/dkr171

DO - 10.1093/jac/dkr171

M3 - Article

SN - 1460-2091

VL - 66

SP - 1886

EP - 1896

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

ER -

Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Abstract

Keywords

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