Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Simona Di Giambenedetto, Iuri Fanti, Andrea De Luca, Mcf Prosperi, N Mackie, M Zazzi, R Camacho, C Torti, A Sönnerborg, R Kaiser, Fm Codoñer, K Van Laethem, L Bansi, Damc Van De Vijver, Am Geretti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

34 Citazioni (Scopus)

Abstract

Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.
Lingua originaleEnglish
pagine (da-a)1886-1896
Numero di pagine11
RivistaJournal of Antimicrobial Chemotherapy
Volume66
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adult
  • Anti-HIV Agents
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Drug Resistance, Viral
  • Europe
  • Female
  • Genotype
  • HIV Infections
  • HIV-1
  • Humans
  • Male
  • Mutation, Missense
  • RNA, Viral
  • Viral Load
  • Viral Proteins

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