Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register

Alessandro Giordano, Massimiliano Mirabella, V. Lepore, C. Bosetti, C. Santucci, P. Iaffaldano, M. Trojano, P. Mosconi, Rocco Totaro, Maria Gabriella Coniglio, Roberto Bruno Bossio, Paola Valentino, Maurizia Gatto, Damiano Paolicelli, Bonaventura Ardito, Valeria Barcella, Lorenzo Capone, Piero Nicolao, Alessandra Lugaresi, Augusto RiniMarta Bianchi, Imma Plasmati, Eleonora Cocco, Renato Docimo, Giovanna De Luca, Fiorella Mondino, Alessia Di Sapio, Raffaella Clerici, Nerina Mascoli, Maria Teresa Ferrò, Clara Grazia Chisari, Davide Maimone, Silvia Strumia, Maura Pugliatti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Background and purpose: In relapsing-remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6-month confirmed disability-worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real-world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability-worsening events and of confirmed disability-worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6-year overall confirmed disability-worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability-worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability-worsening events). Conclusions: In a real-world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability-worsening events unrelated to relapse in RRMS patients.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEUROPEAN JOURNAL OF NEUROLOGY
Volume2020
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Expanded Disability Status Scale
  • disability
  • multiple sclerosis
  • register
  • relapse-remitting
  • worsening

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