Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register

Massimiliano Mirabella, V. Lepore, C. Bosetti, C. Santucci, P. Iaffaldano, M. Trojano, P. Mosconi, Rocco Totaro, Maria Gabriella Coniglio, Roberto Bruno Bossio, Paola Valentino, Maurizia Gatto, Damiano Paolicelli, Bonaventura Ardito, Valeria Barcella, Lorenzo Capone, Piero Nicolao, Alessandra Lugaresi, Augusto Rini, Marta BianchiImma Plasmati, Eleonora Cocco, Renato Docimo, Giovanna De Luca, Fiorella Mondino, Alessia Di Sapio, Raffaella Clerici, Nerina Mascoli, Maria Teresa Ferrò, Clara Grazia Chisari, Davide Maimone, Silvia Strumia, Maura Pugliatti, Daniela Cargnelutti, Luisa Maria Caniatti, Carlo Avolio, Paola Crociani, Maria Pia Amato, Luca Massacesi, Susanna Malagù, Giuseppe Ribizzi, Matilde Inglese, Simonetta Venturi, Paola Gazzola, Nicola Renato Pizio, Giampaolo Brichetto, Katrin Plewnia, Paolo Bellantonio, Roberto Balgera, Francesca De Robertis, Silvia Fermi, Franco Fausto, Monica Mazzoni, Giuseppe Meucci, Elisabetta Cartechini, Guido Cavaletti, Maria Buccafusca, Placido Bramanti, Marzia Romeo, Marco Rovaris, Marco Ronzoni, Paolo Confalonieri, Luca Chiveri, Pierluigi Bertora, Simone Tonietti, Milena De Riz, Alessandra Protti, Patrizia Sola, Carlo Maremmani, Giacomo Lus, Antonio Gallo, Giorgia Teresa Maniscalco, Vincenzo Brescia Morra, Gabriella Cacchio, Rosa Iodice, Michele Ragno, Leonardo Sinisi, Roberto Cantello, Maria Luisa Piras, Giuseppe Salemi, Salvatore Cottone, Luigi M. E. Grimaldi, Francesco Corea, Giuseppe Santangelo, Paolo Immovili, Paolo Gallo, Francesco D'Andrea, Cristina Frittelli, Livia Pasquali, Mario Falcini, Franco Granella, Ilaria Pesci, Anna Luisa Ancona, Roberto Bergamaschi, Antonello Giordano, Mario Di Napoli, Silvia Romano, Carlo Pozzilli, Antonella Conte, Simonetta Galgani, Marco Peresson, Maria Grazia Grasso, Elisabetta Ferraro, Fioravante Capone, Girolama Alessandra Marfia, Daniela De Pascalis, Carlo Piantadosi, Massimiliano Valeriani, Vincenzo Busillo, Paolo Barone, Nicola De Stefano, Monica Ulivelli, Giuseppe Santuccio, Sergio Parodi, Sebastiano Bucello, Sebastiano Traccis, Roberto Zarbo, Tiziana Tassinari, Fabio Bandini, Paola Cavalla, Marinella Clerico, Giulia De Rosa, Antonio Bertolotto, Daniele Imperiale, Paola Sarchielli, Maria Grazia Celani, Marika Vianello, Bruno Marini, Marianna Fortunato, Mauro Zaffaroni, Davide Nasuelli, Paola Banfi, Andrea Mauro Brioschi, Claudio Solaro, Rocco Quatrale, Patrizia Rossi, Alberto Gajofatto, Maria Trojano, Mario Alberto Battaglia, Marco Capobianco, Maura Pugliatti, Monica Ulivelli, Paola Mosconi, Francesco Patti, Maria Pia Amato, Roberto Bergamaschi, Giancarlo Comi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Background and purpose: In relapsing-remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6-month confirmed disability-worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real-world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability-worsening events and of confirmed disability-worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6-year overall confirmed disability-worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability-worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability-worsening events). Conclusions: In a real-world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability-worsening events unrelated to relapse in RRMS patients.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEUROPEAN JOURNAL OF NEUROLOGY
Volume2020
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Expanded Disability Status Scale
  • disability
  • multiple sclerosis
  • register
  • relapse-remitting
  • worsening

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