Abstract
the cardiovascular system. However, elucidation of underlying cellular
mechanisms is hampered by the intricate solubility of lycopene in aqueous
solutions. Cells relevant to the cardiovascular system, including bovine aortic
endothelial cells (BAEC), the monocytic cell line THP-1, and RAT-1 fibroblasts
were treated for various time periods (0 72 h) with different concentrations
of lycopene (1, 5, and 10 mM), solubilized either in tetrahydrofuran
(THF) or micelles as solvents. Incubation of all three cell types led to a
concentration- and time-dependent increase in cellular lycopene content. Both
vehicles tested, THF and micelles, proved equally effective in the delivery of
lycopene to cells. A marked difference in the amount of lycopene incorporated
was observed among the various cell types. Compared with THP-1 cells,
the uptake of lycopene using both solvents was higher in BAEC and RAT-1
fibroblasts for all concentrations and time points tested.
Lingua originale | English |
---|---|
pagine (da-a) | 259-272 |
Numero di pagine | 14 |
Rivista | Journal of Food Lipids |
Stato di pubblicazione | Pubblicato - 2009 |
Pubblicato esternamente | Sì |
Keywords
- incorporation
- lycopene
- vasculor cells