Delayed neutrophil apoptosis in patients with unstable angina: relation to C-reactive protein and recurrence of instability

Luigi Marzio Biasucci, Giovanna Liuzzo, Filippo Crea, Simona Giubilato, Roberta Della Bona, Milena Leo, Michela Pinnelli, Anna Severino, Mario Gabriele, Salvatore Brugaletta, Maddalena Piro

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23 Citazioni (Scopus)

Abstract

AIMS: To investigate spontaneous polymorphonuclear neutrophils (PMNs) apoptosis in unstable angina (UA) and its association with recurrence of instability. METHODS AND RESULTS: We compared PMNs apoptotic rate at 4 and 24 h in patients with UA, stable angina (SA), and controls (H) with two different protocols by flow cytometry. We measured apoptotic rate of isolated PMNs (Protocol 1) in 30 UA patients, 13 SA patients, and 34 H; and apoptosis of PMNs in whole blood culture (Protocol 2) in further 10 UA patients, 7 SA patients, and 6 H. Serum high-sensitivity C-reactive protein was also measured. Polymorphonuclear neutrophils of UA patients showed a decreased apoptotic rate compared with SA patients and H at 4 h in Protocol 1 (both P < 0.01), and at 24 h in Protocol 2 (P < 0.05 and <0.01, respectively). In overall population, a negative correlation was found between apoptotic rate at 4 h and high-sensitivity C-reactive protein levels (P < 0.01). Six among 40 patients with UA had early recurrence of symptoms and their apoptotic rate was significantly reduced compared with UA patients without recurrence of symptoms (P = 0.024). CONCLUSIONS: Our study demonstrates delayed PMN apoptosis in UA. This alteration might be involved in the persistence of inflammatory activation and affects recurrence of instability.
Lingua originaleEnglish
pagine (da-a)2220-2225
Numero di pagine6
RivistaEuropean Heart Journal
Volume2009
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • unstable angina

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