TY - JOUR
T1 - Definition of local recurrence site in resected pancreatic adenocarcinoma: A multicenter study (dolores-1)
AU - Arcelli, Alessandra
AU - Bertini, Federica
AU - Strolin, Silvia
AU - Macchia, Gabriella
AU - Deodato, Francesco
AU - Cilla, Savino
AU - Parisi, Salvatore
AU - Sainato, Aldo
AU - Fiore, Michele
AU - Gabriele, Pietro
AU - Genovesi, Domenico
AU - Cellini, Francesco
AU - Guido, Alessandra
AU - Cammelli, Silvia
AU - Buwenge, Milly
AU - Loi, Emiliano
AU - Bisello, Silvia
AU - Renzulli, Matteo
AU - Golfieri, Rita
AU - Morganti, Alessio G.
AU - Morganti, Alessio Giuseppe
AU - Strigari, Lidia
PY - 2021
Y1 - 2021
N2 - The study aimed to generate a local failure (LF) risk map in resected pancreatic cancer (PC) and validate the results of previous studies, proposing new guidelines for PC postoperative radiotherapy clinical target volume (CTV) delineation. Follow-up computer tomography (CT) of resected PC was retrospectively reviewed by two radiologists identifying LFs and plotting them on a representative patient CT scan. The percentages of LF points randomly extracted based on CTV following the RTOG guidelines and based on the LF database were 70% and 30%, respectively. According to the Kernel density estimation, an LF 3D distribution map was generated and compared with the results of previous studies using a Dice index. Among the 64 resected patients, 59.4% underwent adjuvant treatment. LFs closer to the root of the celiac axis (CA) or the superior mesen-teric artery (SMA) were reported in 32.8% and 67.2% cases, respectively. The mean (± standard de-viation) distances of LF points to CA and SMA were 21.5 ± 17.9 mm and 21.6 ± 12.1 mm, respectively. The Dice values comparing our iso-level risk maps corresponding to 80% and 90% of the LF proba-bilistic density and the CTVs-80 and CTVs-90 of previous publications were 0.45–0.53 and 0.58–0.60, respectively. According to the Kernel density approach, a validated LF map was proposed, modeling a new adjuvant CTV based on a PC pattern of failure.
AB - The study aimed to generate a local failure (LF) risk map in resected pancreatic cancer (PC) and validate the results of previous studies, proposing new guidelines for PC postoperative radiotherapy clinical target volume (CTV) delineation. Follow-up computer tomography (CT) of resected PC was retrospectively reviewed by two radiologists identifying LFs and plotting them on a representative patient CT scan. The percentages of LF points randomly extracted based on CTV following the RTOG guidelines and based on the LF database were 70% and 30%, respectively. According to the Kernel density estimation, an LF 3D distribution map was generated and compared with the results of previous studies using a Dice index. Among the 64 resected patients, 59.4% underwent adjuvant treatment. LFs closer to the root of the celiac axis (CA) or the superior mesen-teric artery (SMA) were reported in 32.8% and 67.2% cases, respectively. The mean (± standard de-viation) distances of LF points to CA and SMA were 21.5 ± 17.9 mm and 21.6 ± 12.1 mm, respectively. The Dice values comparing our iso-level risk maps corresponding to 80% and 90% of the LF proba-bilistic density and the CTVs-80 and CTVs-90 of previous publications were 0.45–0.53 and 0.58–0.60, respectively. According to the Kernel density approach, a validated LF map was proposed, modeling a new adjuvant CTV based on a PC pattern of failure.
KW - Adjuvant chemoradiation
KW - Kernel density estimation
KW - Pancreatic neoplasms
KW - Pattern of failure
KW - Adjuvant chemoradiation
KW - Kernel density estimation
KW - Pancreatic neoplasms
KW - Pattern of failure
UR - http://hdl.handle.net/10807/203387
U2 - 10.3390/cancers13123051
DO - 10.3390/cancers13123051
M3 - Article
SN - 2072-6694
VL - 13
SP - N/A-N/A
JO - Cancers
JF - Cancers
ER -