Defining the biology of intrahepatic cholangiocarcinoma: Molecular pathways and early detection of precursor lesions

G. Gibiino; C. Fabbri; S. Fagiuoli; Gianluca Ianiro; A. Fornelli; V. Cennamo

Defining the biology of intrahepatic cholangiocarcinoma: Molecular pathways and early detection of precursor lesions

G. Gibiino^*, C. Fabbri, S. Fagiuoli, Gianluca Ianiro, A. Fornelli, V. Cennamo

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available. Aim of this review is to summarize the current knowledge about biological features and arising molecular patterns of this disease. The identification of emerging biomarkers and early detection of precursor lesions shall play a key role in the perspective of future tailored targeted therapies.

Lingua originale	Inglese
pagine (da-a)	730-741
Numero di pagine	12
Rivista	European Review for Medical and Pharmacological Sciences
Volume	21
Numero di pubblicazione	4
Stato di pubblicazione	Pubblicato - 2017

All Science Journal Classification (ASJC) codes

Farmacologia (medica)

Keywords

Biliary tract cancer
Biomarker
Cholangiocarcinogenesis
Diagnosis
Endoscopic detection
Targeted biological therapy

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Altri file e collegamenti

Cita questo

@article{c629d8f1249845aea672e1c3ff5645d0,

title = "Defining the biology of intrahepatic cholangiocarcinoma: Molecular pathways and early detection of precursor lesions",

abstract = "Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available. Aim of this review is to summarize the current knowledge about biological features and arising molecular patterns of this disease. The identification of emerging biomarkers and early detection of precursor lesions shall play a key role in the perspective of future tailored targeted therapies.",

keywords = "Biliary tract cancer, Biomarker, Cholangiocarcinogenesis, Diagnosis, Endoscopic detection, Targeted biological therapy, Biliary tract cancer, Biomarker, Cholangiocarcinogenesis, Diagnosis, Endoscopic detection, Targeted biological therapy",

author = "G. Gibiino and C. Fabbri and S. Fagiuoli and Gianluca Ianiro and A. Fornelli and V. Cennamo",

year = "2017",

language = "English",

volume = "21",

pages = "730--741",

journal = "European Review for Medical and Pharmacological Sciences",

issn = "1128-3602",

publisher = "Verduci Editore s.r.l",

number = "4",

}

TY - JOUR

T1 - Defining the biology of intrahepatic cholangiocarcinoma: Molecular pathways and early detection of precursor lesions

AU - Gibiino, G.

AU - Fabbri, C.

AU - Fagiuoli, S.

AU - Ianiro, Gianluca

AU - Fornelli, A.

AU - Cennamo, V.

PY - 2017

Y1 - 2017

N2 - Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available. Aim of this review is to summarize the current knowledge about biological features and arising molecular patterns of this disease. The identification of emerging biomarkers and early detection of precursor lesions shall play a key role in the perspective of future tailored targeted therapies.

AB - Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available. Aim of this review is to summarize the current knowledge about biological features and arising molecular patterns of this disease. The identification of emerging biomarkers and early detection of precursor lesions shall play a key role in the perspective of future tailored targeted therapies.

KW - Biliary tract cancer

KW - Biomarker

KW - Cholangiocarcinogenesis

KW - Diagnosis

KW - Endoscopic detection

KW - Targeted biological therapy

KW - Biliary tract cancer

KW - Biomarker

KW - Cholangiocarcinogenesis

KW - Diagnosis

KW - Endoscopic detection

KW - Targeted biological therapy

UR - https://publicatt.unicatt.it/handle/10807/310866

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85026705194&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026705194&origin=inward

M3 - Article

SN - 1128-3602

VL - 21

SP - 730

EP - 741

JO - European Review for Medical and Pharmacological Sciences

JF - European Review for Medical and Pharmacological Sciences

IS - 4

ER -

Defining the biology of intrahepatic cholangiocarcinoma: Molecular pathways and early detection of precursor lesions

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

Altri file e collegamenti

Fingerprint

Cita questo