Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey

Giorgio Conti, Donato Rigante, Piero Valentini, Marco Cattalini, Sara Della Paolera, Fiammetta Zunica, Claudia Bracaglia, Manuela Giangreco, Lucio Verdoni, Antonella Meini, Rita Sottile, Roberta Caorsi, Gianvincenzo Zuccotti, Marianna Fabi, Davide Montin, Alessandra Meneghel, Alessandro Consolaro, Rosa Maria Dellepiane, Maria Cristina Maggio, Francesco La TorreAlessandra Marchesi, Gabriele Simonini, Alberto Villani, Rolando Cimaz, Angelo Ravelli, Andrea Taddio, Paolo Adamoli, Maria Concetta Alberelli, Clotilde Alizzi, Patrizia Barone, Veronica Bennato, Francesca Biscaro, Grazia Bossi, Andrea Campana, Maurizio Carone, Adele Civino, Giovanni Conti, Eleonora Dei Rossi, Emanuela Del Giudice, Alice Dell’Anna, Maia De Luca, Enrico Felici, Giovanni Filocamo, Ilenia Floretta, Maria Loreta Foschini, Marcello Lanari, Bianca Lattanzi, Alessandra Lazzerotti, Francesco Licciardi, Alessandra Manerba, Savina Mannarino, Achille Marino, Agostina Marolda, Laura Martelli, Giorgia Martini, Angela Mauro, Maria Vincenza Mastrolia, Angelo Mazza, Angela Miniaci, Francesca Minoia, Alma Olivieri, Guido Pennoni, Rossana Pignataro, Francesca Ricci, Matilde Rossi, Claudia Santagati, Martina Soliani, Silvia Sonego, Domenico Sperlì, Sara Stucchi, Barbara Teruzzi, Elpidio Tierno, Tatiana Utytatnikova, Gianluca Vergine

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

Background: There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods: The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients’ outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARSCoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste; AOU Meyer, Florence;IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results: One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/ non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71, 9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p < 0.0001). SARSCoV-2 assay more often resulted positive in KCG than in KDG (75,5% vs 20%; p < 0.0001). Short-term follow data showed minor complications. Comparing KDG with a KD-Historical Italian cohort (598 patients), no statistical difference was found in terms of clinical manifestations and laboratory data. Conclusion: Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths.
Lingua originaleEnglish
pagine (da-a)1-10
Numero di pagine10
RivistaPEDIATRIC RHEUMATOLOGY ONLINE JOURNAL
Volume2021
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Kawasaki disease

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