Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 395-402 |
| Numero di pagine | 8 |
| Rivista | JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES |
| Volume | 72 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2017 |
Keywords
- Aged
- Aged, 80 and over
- Aging
- Aging phenotypes
- Cluster analysis
- Female
- Frail Elderly
- Frailty
- Geriatric Assessment
- Hospital Mortality
- Hospitalization
- Humans
- Internal medicine and geriatric wards
- Male
- Outcomes
- Phenotype
- Prospective Studies
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In: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, Vol. 72, 2017, pag. 395-402.
Risultato della ricerca: Contributo in rivista › Articolo in rivista
TY - JOUR
T1 - Defining aging phenotypes and related outcomes: Clues to recognize frailty in hospitalized older patients
AU - Marcucci, Maura
AU - Franchi, Carlotta
AU - Nobili, Alessandro
AU - Mannucci, Pier Mannuccio
AU - Ardoino, Ilaria
AU - Tettamanti, Mauro
AU - Pasina, Luca
AU - Perticone, Francesco
AU - Salerno, Francesco
AU - Corrao, Salvatore
AU - Marengoni, Alessandra
AU - Licata, Giuseppe
AU - Violi, Francesco
AU - Corazza, Gino Roberto
AU - Eldin, Tarek Kamal
AU - Di Blanca, Maria Pia Donatella
AU - Djade, Codjo Djignefa
AU - Cortesi, Laura
AU - Prisco, Domenico
AU - Silvestri, Elena
AU - Cenci, Caterina
AU - Emmi, Giacomo
AU - Biolo, Gianni
AU - Guarnieri, Gianfranco
AU - Zanetti, Michela
AU - Fernandes, Giovanni
AU - Vanoli, Massimo
AU - Grignani, Giulia
AU - Casella, Gianluca
AU - Bernardi, Mauro
AU - Bassi, Silvia Li
AU - Santi, Luca
AU - Zaccherini, Giacomo
AU - Mannarino, Elmo
AU - Lupattelli, Graziana
AU - Bianconi, Vanessa
AU - Paciullo, Francesco
AU - Nuti, Ranuccio
AU - Valenti, Roberto
AU - Ruvio, Martina
AU - Cappelli, Silvia
AU - Palazzuoli, Alberto
AU - Salvatore, Teresa
AU - Sasso, Ferdinando Carlo
AU - Girelli, Domenico
AU - Girelli, Davide Nicola
AU - Olivieri, Oliviero
AU - Matteazzi, Thomas
AU - Barbagallo, Mario
AU - Plances, Lidia
AU - Alcamo, Roberta
AU - Calvo, Luigi
AU - Valentini, Maria
AU - Zoli, Marco
AU - Arnò, Raffaella
AU - Pasini, Franco Laghi
AU - Capecchi, Pier Leopoldo
AU - Bicchi, Maurizio
AU - Palasciano, Giuseppe
AU - Modeo, Maria Ester
AU - Peragine, Maria
AU - Pappagallo, Fabrizio
AU - Pugliese, Stefania
AU - Di Gennaro, Carla
AU - Postiglione, Alfredo
AU - Barbella, Maria Rosaria
AU - De Stefano, Francesco
AU - Cappellini, Maria Domenica
AU - Fabio, Giovanna
AU - Seghezzi, Sonia
AU - De Amicis, Margherita Migone
AU - Mari, Daniela
AU - Rossi, Paolo Dionigi
AU - Damanti, Sarah
AU - Ottolini, Barbara Brignolo
AU - Miceli, Emanuela
AU - Lenti, Marco Vincenzo
AU - Padula, Donatella
AU - Murialdo, Giovanni
AU - Marra, Alessio
AU - Cattaneo, Federico
AU - Secchi, Maria Beatrice
AU - Ghelfi, Davide
AU - Anastasio, Luigi
AU - Sofia, Lucia
AU - Carbone, Maria
AU - Davì, Giovanni
AU - Guagnano, Maria Teresa
AU - Sestili, Simona
AU - Mancuso, Gerardo
AU - Calipari, Daniela
AU - Bartone, Mosè
AU - Meroni, Maria Rachele
AU - Perin, Paolo Cavallo
AU - Lorenzati, Bartolomeo
AU - Gruden, Gabriella
AU - Bruno, Graziella
AU - Amione, Cristina
AU - Fornengo, Paolo
AU - Tassara, Rodolfo
AU - Melis, Deborah
AU - Rebella, Lara
AU - Delitala, Giuseppe
AU - Pretti, Vincenzo
AU - Masala, Maristella Salvatora
AU - Bolondi, Luigi
AU - Rasciti, Leonardo
AU - Serio, Ilaria
AU - Fanelli, Filippo Rossi
AU - Amoroso, Antonio
AU - Molfino, Alessio
AU - Petrillo, Enrico
AU - Zuccala', Giuseppe
AU - Franceschi, Francesco
AU - De Marco, Guido
AU - Chiara, Cordischi
AU - Marta, Sabbatini
AU - Romanelli, Giuseppe
AU - Amolini, Claudia
AU - Chiesa, Deborah
AU - Picardi, Antonio
AU - Gentilucci, Umberto Vespasiani
AU - Gallo, Paolo
AU - Annoni, Giorgio
AU - Corsi, Maurizio
AU - Zazzetta, Sara
AU - Bellelli, Giuseppe
AU - Arturi, Franco
AU - Succurro, Elena
AU - Rubino, Mariangela
AU - Sesti, Giorgio
AU - Loria, Paola
AU - Becchi, Maria Angela
AU - Martucci, Gianfranco
AU - Fantuzzi, Alessandra
AU - Maurantonio, Mauro
AU - Carta, Stefano
AU - Atzori, Sebastiana
AU - Serra, Maria Grazia
AU - Bleve, Maria Antonietta
AU - Gasbarrone, Laura
AU - Sajeva, Maria Rosaria
AU - Brucato, Antonio
AU - Ghidoni, Silvia
AU - Di Corato, Paola
AU - Agnelli, Giancarlo
AU - Marchesini, Emanuela
AU - Fabris, Fabrizio
AU - Carlon, Michela
AU - Turatto, Francesca
AU - Baritusso, Aldo
AU - Manfredini, Roberto
AU - Molino, Christian
AU - Pala, Marco
AU - Fabbian, Fabio
AU - Boari, Benedetta
AU - De Giorgi, Alfredo
AU - Paolisso, Giuseppe
AU - Rizzo, Maria Rosaria
AU - Laieta, Maria Teresa
AU - Rini, Giovanbattista
AU - Mansueto, Pasquale
AU - Pepe, Ilenia
AU - Borghi, Claudio
AU - Strocchi, Enrico
AU - De Sando, Valeria
AU - Sabbà, Carlo
AU - Vella, Francesco Saverio
AU - Suppressa, Patrizia
AU - Valerio, Raffaella
AU - Capobianco, Caterina
AU - Fenoglio, Luigi
AU - Bracco, Christian
AU - Giraudo, Alessia Valentina
AU - Testa, Elisa
AU - Serraino, Cristina
AU - Fargion, Silvia
AU - Bonara, Paola
AU - Periti, Giulia
AU - Porzio, Marianna
AU - Peyvandi, Flora
AU - Tedeschi, Alberto
AU - Rossio, Raffaella
AU - Monzani, Valter
AU - Savojardo, Valeria
AU - Folli, Christian
AU - Magnini, Maria
AU - Conca, Alessio
AU - Gobbo, Giulia
AU - Balduini, Carlo L.
AU - Bertolino, Giampiera
AU - Provini, Stella
AU - Quaglia, Federica
AU - Dallegri, Franco
AU - Ottonello, Luciano
AU - Liberale, Luca
AU - Chin, Wu Sheng
AU - Carassale, Laura
AU - Caporotundo, Silvia
AU - Traisci, Giancarlo
AU - De Feudis, Lucrezia
AU - Di Carlo, Silvia
AU - Liberato, Nicola Lucio
AU - Buratti, Alberto
AU - Tognin, Tiziana
AU - Bianchi, Giovanni Battista
AU - Giaquinto, Sabrina
AU - Purrello, Francesco
AU - Di Pino, Antonino
AU - Di Pino, Antonella
AU - Piro, Salvatore
AU - Rozzini, Renzo
AU - Falanga, Lina
AU - Montrucchio, Giuseppe
AU - Greco, Elisabetta
AU - Tizzani, Pietro
AU - Petitti, Paolo
AU - Perciccante, Antonio
AU - Coralli, Alessia
AU - Salmi, Raffaella
AU - Gaudenzi, Piergiorgio
AU - Gamberini, Susanna
AU - Semplicini, Andrea
AU - Gottardo, Lucia
AU - Vendemiale, Gianluigi
AU - Serviddio, Gaetano
AU - Forlano, Roberta
AU - Masala, Cesare
AU - Mammarella, Antonio
AU - Raparelli, Valeria
AU - Basili, Stefania
AU - Perri, Ludovica
AU - Landolfi, Raffaele
AU - Montalto, Massimo
AU - Mirijello, Antonio
AU - Vallone, Carla
AU - Bellusci, Martino
AU - Setti, Donatella
AU - Pedrazzoli, Filippo
AU - Guasti, Luigina
AU - Castiglioni, Luana
AU - Maresca, Andrea
AU - Squizzato, Alessandro
AU - Molaro, Marta
AU - Bertolotti, Marco
AU - Mussi, Chiara
AU - Libbra, Maria Vittoria
AU - Miceli, Andrea
AU - Pellegrini, Elisa
AU - Carulli, Lucia
AU - Sciacqua, Angela
AU - Quero, Michele
AU - Bagnato, Chiara
AU - Corinaldesi, Roberto
AU - De Giorgio, Roberto
AU - Serra, Mauro
AU - Grasso, Valentina
AU - Ruggeri, Eugenio
AU - Salvi, Andrea
AU - Leonardi, Roberto
AU - Grassini, Chiara
AU - Mascherona, Ilenia
AU - Minelli, Giorgio
AU - Maltese, Francesca
AU - Gabrielli, Armando
AU - Gabrielli, Francesca Augusta
AU - Mattioli, Massimo
AU - Capeci, William
AU - Martino, Giuseppe Pio
AU - Messina, Silvia
AU - Ghio, Riccardi
AU - Favorini, Serena
AU - Dal Col, Anna
AU - Minisola, Salvatore
AU - Colangelo, Luciano
AU - Afeltra, Antonella
AU - Alemanno, Pamela
AU - Marigliano, Benedetta
AU - Castellino, Pietro
AU - Blanco, Julien
AU - Zanoli, Luca
AU - Cattaneo, Marco
AU - Fracasso, Paola
AU - Amoruso, Maria Valentina
AU - Saracco, Valter
AU - Fogliati, Marisa
AU - Bussolino, Carlo
AU - Durante, Vittorio
AU - Eusebi, Giovanna
AU - Tirotta, Daniela
AU - Mete, Francesca
AU - Gino, Miriam
AU - Cittadini, Antonio
AU - Arcopinto, Michele
AU - Salzano, Andrea
AU - Bobbio, Emanuele
AU - Marra, Alberto Maria
AU - Sirico, Domenico
AU - Moreo, Guido
AU - Scopelliti, Francesco
AU - Gasparini, Francesca
AU - Cocca, Melissa
AU - Nieves, Ramirez Duque
AU - Alberto, Muela Molinero
AU - Pedro, Abad Requejo
AU - Vanessa, Lopez Pelaez
AU - Lara, Tamargo
AU - Xavier, Corbella Viros
AU - Francesc, Formiga
AU - Jesus, Diez Manglano
AU - Esperanza, Bejarano Tello
AU - Esther, Del Corral Behamonte
AU - Maria, Sevil Puras
AU - Romero, Manuel
AU - Blanca, Pinilla Llorente
AU - Cristina, Lopez Gonzalez-Cobos
AU - Victoria, Villalba Garcia M.
AU - Saez, Lopez
AU - Bosco, Juan
AU - Susana, Sanz Baena
AU - Marta, Arroyo Gallego
AU - Concepcion, Gonzalez Becerra
AU - Antonio, Fernandez Moyano
AU - Hernandez, Mercedes Gomez
AU - Borrego, Manuel Poyato
AU - Raquel, Pacheco Cuadros
AU - Florencia, Perez Rojas
AU - Beatriz, Garcia Olid
AU - Sara, Carrascosa Garcia
AU - Alfonso, Gonzalez-Cruz Cervellera
AU - Marta, Peinado Martinez
AU - Alberto, Ruiz Cantero
AU - Antonio, Albarracín Arraigosa
AU - Montserrat, Godoy Guerrero
AU - Ángel, Barón Ramos Miguel
AU - Manuel, Machin Jose
AU - Ignacio, Novo Veleiro
AU - Lucía, Alvela Suarez
AU - Alfonso, Lopez
AU - David, Rubal Bran
AU - Iria, Iñiguez Vazquez
AU - Monica, Rios Prego
PY - 2017
Y1 - 2017
N2 - Background: Because frailty is a complex phenomenon associated with poor outcomes, the identification of patient profiles with different care needs might be of greater practical help than to look for a unifying definition. This study aimed at identifying aging phenotypes and their related outcomes in order to recognize frailty in hospitalized older patients. Methods: Patients aged 65 or older enrolled in internal medicine and geriatric wards participating in the REPOSI registry. Relationships among variables associated to sociodemographic, physical, cognitive, functional, and medical status were explored using a multiple correspondence analysis. The hierarchical cluster analysis was then performed to identify possible patient profiles. Multivariable logistic regression was used to verify the association between clusters and outcomes (in-hospital mortality and 3-month postdischarge mortality and rehospitalization). Results: 2,841 patients were included in the statistical analyses. Four clusters were identified: the healthiest (I); those with multimorbidity (II); the functionally independent women with osteoporosis and arthritis (III); and the functionally dependent oldest old patients with cognitive impairment (IV). There was a significantly higher in-hospital mortality in Cluster II (odds ratio [OR] = 2.27, 95% confidence interval [CI] = 1.15-4.46) and Cluster IV (OR = 5.15, 95% CI = 2.58-10.26) and a higher 3-month mortality in Cluster II (OR = 1.66, 95% CI = 1.13-2.44) and Cluster IV (OR = 1.86, 95% CI = 1.15-3.00) than in Cluster I. Conclusions: Using alternative analytical techniques among hospitalized older patients, we could distinguish different frailty phenotypes, differently associated with adverse events. The identification of different patient profiles can help defining the best care strategy according to specific patient needs.
AB - Background: Because frailty is a complex phenomenon associated with poor outcomes, the identification of patient profiles with different care needs might be of greater practical help than to look for a unifying definition. This study aimed at identifying aging phenotypes and their related outcomes in order to recognize frailty in hospitalized older patients. Methods: Patients aged 65 or older enrolled in internal medicine and geriatric wards participating in the REPOSI registry. Relationships among variables associated to sociodemographic, physical, cognitive, functional, and medical status were explored using a multiple correspondence analysis. The hierarchical cluster analysis was then performed to identify possible patient profiles. Multivariable logistic regression was used to verify the association between clusters and outcomes (in-hospital mortality and 3-month postdischarge mortality and rehospitalization). Results: 2,841 patients were included in the statistical analyses. Four clusters were identified: the healthiest (I); those with multimorbidity (II); the functionally independent women with osteoporosis and arthritis (III); and the functionally dependent oldest old patients with cognitive impairment (IV). There was a significantly higher in-hospital mortality in Cluster II (odds ratio [OR] = 2.27, 95% confidence interval [CI] = 1.15-4.46) and Cluster IV (OR = 5.15, 95% CI = 2.58-10.26) and a higher 3-month mortality in Cluster II (OR = 1.66, 95% CI = 1.13-2.44) and Cluster IV (OR = 1.86, 95% CI = 1.15-3.00) than in Cluster I. Conclusions: Using alternative analytical techniques among hospitalized older patients, we could distinguish different frailty phenotypes, differently associated with adverse events. The identification of different patient profiles can help defining the best care strategy according to specific patient needs.
KW - Aged
KW - Aged, 80 and over
KW - Aging
KW - Aging phenotypes
KW - Cluster analysis
KW - Female
KW - Frail Elderly
KW - Frailty
KW - Geriatric Assessment
KW - Hospital Mortality
KW - Hospitalization
KW - Humans
KW - Internal medicine and geriatric wards
KW - Male
KW - Outcomes
KW - Phenotype
KW - Prospective Studies
KW - Aged
KW - Aged, 80 and over
KW - Aging
KW - Aging phenotypes
KW - Cluster analysis
KW - Female
KW - Frail Elderly
KW - Frailty
KW - Geriatric Assessment
KW - Hospital Mortality
KW - Hospitalization
KW - Humans
KW - Internal medicine and geriatric wards
KW - Male
KW - Outcomes
KW - Phenotype
KW - Prospective Studies
UR - http://hdl.handle.net/10807/172259
U2 - 10.1093/gerona/glw188
DO - 10.1093/gerona/glw188
M3 - Article
SN - 1079-5006
VL - 72
SP - 395
EP - 402
JO - JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
JF - JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ER -