Defining aging phenotypes and related outcomes: Clues to recognize frailty in hospitalized older patients

Giuseppe Zuccala', Francesco Franceschi, Massimo Montalto, Davide Nicola Girelli, Antonella Di Pino, Raffaele Landolfi, Francesca Augusta Gabrielli, Maura Marcucci, Carlotta Franchi, Alessandro Nobili, Pier Mannuccio Mannucci, Ilaria Ardoino, Mauro Tettamanti, Luca Pasina, Francesco Perticone, Francesco Salerno, Salvatore Corrao, Alessandra Marengoni, Giuseppe Licata, Francesco VioliGino Roberto Corazza, Tarek Kamal Eldin, Maria Pia Donatella Di Blanca, Codjo Djignefa Djade, Laura Cortesi, Domenico Prisco, Elena Silvestri, Caterina Cenci, Giacomo Emmi, Gianni Biolo, Gianfranco Guarnieri, Michela Zanetti, Giovanni Fernandes, Massimo Vanoli, Giulia Grignani, Gianluca Casella, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giacomo Zaccherini, Elmo Mannarino, Graziana Lupattelli, Vanessa Bianconi, Francesco Paciullo, Ranuccio Nuti, Roberto Valenti, Martina Ruvio, Silvia Cappelli, Alberto Palazzuoli, Teresa Salvatore, Ferdinando Carlo Sasso, Domenico Girelli, Oliviero Olivieri, Thomas Matteazzi, Mario Barbagallo, Lidia Plances, Roberta Alcamo, Luigi Calvo, Maria Valentini, Marco Zoli, Raffaella Arnò, Franco Laghi Pasini, Pier Leopoldo Capecchi, Maurizio Bicchi, Giuseppe Palasciano, Maria Ester Modeo, Maria Peragine, Fabrizio Pappagallo, Stefania Pugliese, Carla Di Gennaro, Alfredo Postiglione, Maria Rosaria Barbella, Francesco De Stefano, Maria Domenica Cappellini, Giovanna Fabio, Sonia Seghezzi, Margherita Migone De Amicis, Daniela Mari, Paolo Dionigi Rossi, Sarah Damanti, Barbara Brignolo Ottolini, Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Giovanni Murialdo, Alessio Marra, Federico Cattaneo, Maria Beatrice Secchi, Davide Ghelfi, Luigi Anastasio, Lucia Sofia, Maria Carbone, Giovanni Davì, Maria Teresa Guagnano, Simona Sestili, Gerardo Mancuso, Daniela Calipari, Mosè Bartone, Maria Rachele Meroni, Paolo Cavallo Perin, Bartolomeo Lorenzati, Gabriella Gruden, Graziella Bruno, Cristina Amione, Paolo Fornengo, Rodolfo Tassara, Deborah Melis, Lara Rebella, Giuseppe Delitala, Vincenzo Pretti, Maristella Salvatora Masala, Luigi Bolondi, Leonardo Rasciti, Ilaria Serio, Filippo Rossi Fanelli, Antonio Amoroso, Alessio Molfino, Enrico Petrillo, Giuseppe Romanelli, Claudia Amolini, Deborah Chiesa, Antonio Picardi, Umberto Vespasiani Gentilucci, Paolo Gallo, Giorgio Annoni, Maurizio Corsi, Sara Zazzetta, Giuseppe Bellelli, Franco Arturi, Elena Succurro, Mariangela Rubino, Giorgio Sesti, Paola Loria, Maria Angela Becchi, Gianfranco Martucci, Alessandra Fantuzzi, Mauro Maurantonio, Stefano Carta, Sebastiana Atzori, Maria Grazia Serra, Maria Antonietta Bleve, Laura Gasbarrone, Maria Rosaria Sajeva, Antonio Brucato, Silvia Ghidoni, Paola Di Corato, Giancarlo Agnelli, Emanuela Marchesini, Fabrizio Fabris, Michela Carlon, Francesca Turatto, Aldo Baritusso, Roberto Manfredini, Christian Molino, Marco Pala, Fabio Fabbian, Benedetta Boari, Alfredo De Giorgi, Giuseppe Paolisso, Maria Rosaria Rizzo, Maria Teresa Laieta, Giovanbattista Rini, Pasquale Mansueto, Ilenia Pepe, Claudio Borghi, Enrico Strocchi, Valeria De Sando, Carlo Sabbà, Francesco Saverio Vella, Patrizia Suppressa, Raffaella Valerio, Caterina Capobianco, Luigi Fenoglio, Christian Bracco, Alessia Valentina Giraudo, Elisa Testa, Cristina Serraino, Silvia Fargion, Paola Bonara, Giulia Periti, Marianna Porzio, Flora Peyvandi, Alberto Tedeschi, Raffaella Rossio, Valter Monzani, Valeria Savojardo, Christian Folli, Maria Magnini, Alessio Conca, Giulia Gobbo, Carlo L. Balduini, Giampiera Bertolino, Stella Provini, Federica Quaglia, Franco Dallegri, Luciano Ottonello, Luca Liberale, Wu Sheng Chin, Laura Carassale, Silvia Caporotundo, Giancarlo Traisci, Lucrezia De Feudis, Silvia Di Carlo, Nicola Lucio Liberato, Alberto Buratti, Tiziana Tognin, Giovanni Battista Bianchi, Sabrina Giaquinto, Francesco Purrello, Antonino Di Pino, Salvatore Piro, Renzo Rozzini, Lina Falanga, Giuseppe Montrucchio, Elisabetta Greco, Pietro Tizzani, Paolo Petitti, Antonio Perciccante, Alessia Coralli, Raffaella Salmi, Piergiorgio Gaudenzi, Susanna Gamberini, Andrea Semplicini, Lucia Gottardo, Gianluigi Vendemiale, Gaetano Serviddio, Roberta Forlano, Cesare Masala, Antonio Mammarella, Valeria Raparelli, Stefania Basili, Ludovica Perri, Martino Bellusci, Donatella Setti, Filippo Pedrazzoli, Luigina Guasti, Luana Castiglioni, Andrea Maresca, Alessandro Squizzato, Marta Molaro, Marco Bertolotti, Chiara Mussi, Maria Vittoria Libbra, Andrea Miceli, Elisa Pellegrini, Lucia Carulli, Angela Sciacqua, Michele Quero, Chiara Bagnato, Roberto Corinaldesi, Roberto De Giorgio, Mauro Serra, Valentina Grasso, Eugenio Ruggeri, Andrea Salvi, Roberto Leonardi, Chiara Grassini, Ilenia Mascherona, Giorgio Minelli, Francesca Maltese, Armando Gabrielli, Massimo Mattioli, William Capeci, Giuseppe Pio Martino, Silvia Messina, Riccardi Ghio, Serena Favorini, Anna Dal Col, Salvatore Minisola, Luciano Colangelo, Antonella Afeltra, Pamela Alemanno, Benedetta Marigliano, Pietro Castellino, Julien Blanco, Luca Zanoli, Marco Cattaneo, Paola Fracasso, Maria Valentina Amoruso, Valter Saracco, Marisa Fogliati, Carlo Bussolino, Vittorio Durante, Giovanna Eusebi, Daniela Tirotta, Francesca Mete, Miriam Gino, Antonio Cittadini, Michele Arcopinto, Andrea Salzano, Emanuele Bobbio, Alberto Maria Marra, Domenico Sirico, Guido Moreo, Francesco Scopelliti, Francesca Gasparini, Melissa Cocca, Ramirez Duque Nieves, Muela Molinero Alberto, Abad Requejo Pedro, Lopez Pelaez Vanessa, Tamargo Lara, Corbella Viros Xavier, Formiga Francesc, Diez Manglano Jesus, Bejarano Tello Esperanza, Del Corral Behamonte Esther, Sevil Puras Maria, Manuel Romero, Pinilla Llorente Blanca, Lopez Gonzalez-Cobos Cristina, Villalba Garcia M. Victoria, Lopez Saez, Juan Bosco, Sanz Baena Susana, Arroyo Gallego Marta, Gonzalez Becerra Concepcion, Fernandez Moyano Antonio, Mercedes Gomez Hernandez, Manuel Poyato Borrego, Pacheco Cuadros Raquel, Perez Rojas Florencia, Garcia Olid Beatriz, Carrascosa Garcia Sara, Gonzalez-Cruz Cervellera Alfonso, Peinado Martinez Marta, Ruiz Cantero Alberto, Albarracín Arraigosa Antonio, Godoy Guerrero Montserrat, Barón Ramos Miguel Ángel, Machin Jose Manuel, Novo Veleiro Ignacio, Alvela Suarez Lucía, Lopez Alfonso, Rubal Bran David, Iñiguez Vazquez Iria, Rios Prego Monica

Risultato della ricerca: Contributo in rivistaArticolo in rivista

21 Citazioni (Scopus)

Abstract

Background: Because frailty is a complex phenomenon associated with poor outcomes, the identification of patient profiles with different care needs might be of greater practical help than to look for a unifying definition. This study aimed at identifying aging phenotypes and their related outcomes in order to recognize frailty in hospitalized older patients. Methods: Patients aged 65 or older enrolled in internal medicine and geriatric wards participating in the REPOSI registry. Relationships among variables associated to sociodemographic, physical, cognitive, functional, and medical status were explored using a multiple correspondence analysis. The hierarchical cluster analysis was then performed to identify possible patient profiles. Multivariable logistic regression was used to verify the association between clusters and outcomes (in-hospital mortality and 3-month postdischarge mortality and rehospitalization). Results: 2,841 patients were included in the statistical analyses. Four clusters were identified: the healthiest (I); those with multimorbidity (II); the functionally independent women with osteoporosis and arthritis (III); and the functionally dependent oldest old patients with cognitive impairment (IV). There was a significantly higher in-hospital mortality in Cluster II (odds ratio [OR] = 2.27, 95% confidence interval [CI] = 1.15-4.46) and Cluster IV (OR = 5.15, 95% CI = 2.58-10.26) and a higher 3-month mortality in Cluster II (OR = 1.66, 95% CI = 1.13-2.44) and Cluster IV (OR = 1.86, 95% CI = 1.15-3.00) than in Cluster I. Conclusions: Using alternative analytical techniques among hospitalized older patients, we could distinguish different frailty phenotypes, differently associated with adverse events. The identification of different patient profiles can help defining the best care strategy according to specific patient needs.
Lingua originaleEnglish
pagine (da-a)395-402
Numero di pagine8
RivistaJOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume72
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Aged
  • Aged, 80 and over
  • Aging
  • Aging phenotypes
  • Cluster analysis
  • Female
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Internal medicine and geriatric wards
  • Male
  • Outcomes
  • Phenotype
  • Prospective Studies

Fingerprint Entra nei temi di ricerca di 'Defining aging phenotypes and related outcomes: Clues to recognize frailty in hospitalized older patients'. Insieme formano una fingerprint unica.

Cita questo