Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives

Erica De Candia; A Pecci; G Ciabattoni; Raimondo De Cristofaro; Sergio Rutella; Z Yao Wu; Ilaria Lazzareschi; Raffaele Landolfi; S Coughlin; Cl Balduini

doi:10.1111/j.1538-7836.2007.02329.x

Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives

Erica De Candia
, A Pecci
, G Ciabattoni
, Raimondo De Cristofaro
, Sergio Rutella
, Z Yao Wu
, Ilaria Lazzareschi
, Raffaele Landolfi
, S Coughlin
, Cl Balduini

Risultato della ricerca: Contributo in rivista › Articolo

24 Citazioni (Scopus)

Abstract

We report a novel case of gray platelet syndrome (GPS). A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly.

Lingua originale	Inglese
pagine (da-a)	551-559
Numero di pagine	9
Rivista	Journal of Thrombosis and Haemostasis
Volume	5
Numero di pubblicazione	3
DOI	https://doi.org/10.1111/j.1538-7836.2007.02329.x
Stato di pubblicazione	Pubblicato - 2007

All Science Journal Classification (ASJC) codes

Ematologia

Keywords

Adolescent
Adult
Aged
Blood Platelets
Calcium Signaling
Coagulants
Cytoplasmic Granules
Family
Female
Fluorescence
Humans
Male
Microscopy
Middle Aged
Oligopeptides
P-Selectin
PAR-1
Pedigree
Phenotype
Platelet Aggregation
Platelet Factor 4
Platelet Function Tests
Platelet Storage Pool Deficiency
Receptor
Syndrome
Thrombin
Thrombospondin 1
Thromboxane B2

Accesso al documento

10.1111/j.1538-7836.2007.02329.x

Altri file e collegamenti

Fingerprint

Entra nei temi di ricerca di 'Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives'. Insieme formano una fingerprint unica.

Cita questo

De Candia, E., Pecci, A., Ciabattoni, G., De Cristofaro, R., Rutella, S., Yao Wu, Z., Lazzareschi, I., Landolfi, R., Coughlin, S., & Balduini, C. (2007). Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. Journal of Thrombosis and Haemostasis, 5(3), 551-559. https://doi.org/10.1111/j.1538-7836.2007.02329.x

@article{65f756cadbf24976af5404148b744485,

title = "Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives",

abstract = "We report a novel case of gray platelet syndrome (GPS). A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly.",

keywords = "Adolescent, Adult, Aged, Blood Platelets, Calcium Signaling, Coagulants, Cytoplasmic Granules, Family, Female, Fluorescence, Humans, Male, Microscopy, Middle Aged, Oligopeptides, P-Selectin, PAR-1, Pedigree, Phenotype, Platelet Aggregation, Platelet Factor 4, Platelet Function Tests, Platelet Storage Pool Deficiency, Receptor, Syndrome, Thrombin, Thrombospondin 1, Thromboxane B2, Adolescent, Adult, Aged, Blood Platelets, Calcium Signaling, Coagulants, Cytoplasmic Granules, Family, Female, Fluorescence, Humans, Male, Microscopy, Middle Aged, Oligopeptides, P-Selectin, PAR-1, Pedigree, Phenotype, Platelet Aggregation, Platelet Factor 4, Platelet Function Tests, Platelet Storage Pool Deficiency, Receptor, Syndrome, Thrombin, Thrombospondin 1, Thromboxane B2",

author = "\{De Candia\}, Erica and A Pecci and G Ciabattoni and \{De Cristofaro\}, Raimondo and Sergio Rutella and \{Yao Wu\}, Z and Ilaria Lazzareschi and Raffaele Landolfi and S Coughlin and Cl Balduini",

year = "2007",

doi = "10.1111/j.1538-7836.2007.02329.x",

language = "English",

volume = "5",

pages = "551--559",

journal = "Journal of Thrombosis and Haemostasis",

issn = "1538-7933",

publisher = "Elsevier B.V.",

number = "3",

}

De Candia, E, Pecci, A, Ciabattoni, G, De Cristofaro, R, Rutella, S, Yao Wu, Z, Lazzareschi, I, Landolfi, R, Coughlin, S & Balduini, C 2007, 'Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives', Journal of Thrombosis and Haemostasis, vol. 5, n. 3, pagg. 551-559. https://doi.org/10.1111/j.1538-7836.2007.02329.x

Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. / De Candia, Erica; Pecci, A; Ciabattoni, G et al.
In: Journal of Thrombosis and Haemostasis, Vol. 5, N. 3, 2007, pag. 551-559.

Risultato della ricerca: Contributo in rivista › Articolo

TY - JOUR

T1 - Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives

AU - De Candia, Erica

AU - Pecci, A

AU - Ciabattoni, G

AU - De Cristofaro, Raimondo

AU - Rutella, Sergio

AU - Yao Wu, Z

AU - Lazzareschi, Ilaria

AU - Landolfi, Raffaele

AU - Coughlin, S

AU - Balduini, Cl

PY - 2007

Y1 - 2007

N2 - We report a novel case of gray platelet syndrome (GPS). A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly.

AB - We report a novel case of gray platelet syndrome (GPS). A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly.

KW - Adolescent

KW - Adult

KW - Aged

KW - Blood Platelets

KW - Calcium Signaling

KW - Coagulants

KW - Cytoplasmic Granules

KW - Family

KW - Female

KW - Fluorescence

KW - Humans

KW - Male

KW - Microscopy

KW - Middle Aged

KW - Oligopeptides

KW - P-Selectin

KW - PAR-1

KW - Pedigree

KW - Phenotype

KW - Platelet Aggregation

KW - Platelet Factor 4

KW - Platelet Function Tests

KW - Platelet Storage Pool Deficiency

KW - Receptor

KW - Syndrome

KW - Thrombin

KW - Thrombospondin 1

KW - Thromboxane B2

KW - Adolescent

KW - Adult

KW - Aged

KW - Blood Platelets

KW - Calcium Signaling

KW - Coagulants

KW - Cytoplasmic Granules

KW - Family

KW - Female

KW - Fluorescence

KW - Humans

KW - Male

KW - Microscopy

KW - Middle Aged

KW - Oligopeptides

KW - P-Selectin

KW - PAR-1

KW - Pedigree

KW - Phenotype

KW - Platelet Aggregation

KW - Platelet Factor 4

KW - Platelet Function Tests

KW - Platelet Storage Pool Deficiency

KW - Receptor

KW - Syndrome

KW - Thrombin

KW - Thrombospondin 1

KW - Thromboxane B2

UR - https://publicatt.unicatt.it/handle/10807/63701

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=34247600608&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247600608&origin=inward

U2 - 10.1111/j.1538-7836.2007.02329.x

DO - 10.1111/j.1538-7836.2007.02329.x

M3 - Article

SN - 1538-7933

VL - 5

SP - 551

EP - 559

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 3

ER -

De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao Wu Z et al. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. Journal of Thrombosis and Haemostasis. 2007;5(3):551-559. doi: 10.1111/j.1538-7836.2007.02329.x