Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models

Alice Rossi; Giulia Rigotto; Giulia Valente; Giustina Valente; Valentina Giorgio; Emy Basso; Enrico Basso; Riccardo Filadi; Paola Pizzo

doi:10.1016/j.celrep.2020.01.060

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models

Alice Rossi
, Giulia Rigotto
, Giulia Valente
, Giustina Valente
, Valentina Giorgio
, Emy Basso
, Enrico Basso
, Riccardo Filadi
, Paola Pizzo

University of Padua

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.

Lingua originale	Inglese
pagine (da-a)	2332-2348.e10
Rivista	Cell Reports
Volume	30
DOI	https://doi.org/10.1016/j.celrep.2020.01.060
Stato di pubblicazione	Pubblicato - 2020

Keywords

Alzheimer's disease
GSK-3b
bioenergetics
calcium homeostasis
hexokinase 1
mitochondrial metabolism
mitochondrial pyruvate carrier
presenilin
pyruvate

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10.1016/j.celrep.2020.01.060

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title = "Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models",

abstract = "Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.",

keywords = "Alzheimer's disease, GSK-3b, bioenergetics, calcium homeostasis, hexokinase 1, mitochondrial metabolism, mitochondrial pyruvate carrier, presenilin, pyruvate, Alzheimer's disease, GSK-3b, bioenergetics, calcium homeostasis, hexokinase 1, mitochondrial metabolism, mitochondrial pyruvate carrier, presenilin, pyruvate",

author = "Alice Rossi and Giulia Rigotto and Giulia Valente and Giustina Valente and Valentina Giorgio and Emy Basso and Enrico Basso and Riccardo Filadi and Paola Pizzo",

year = "2020",

doi = "10.1016/j.celrep.2020.01.060",

language = "English",

volume = "30",

pages = "2332--2348.e10",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models

AU - Rossi, Alice

AU - Rigotto, Giulia

AU - Valente, Giulia

AU - Valente, Giustina

AU - Giorgio, Valentina

AU - Basso, Emy

AU - Basso, Enrico

AU - Filadi, Riccardo

AU - Pizzo, Paola

PY - 2020

Y1 - 2020

N2 - Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.

AB - Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.

KW - Alzheimer's disease

KW - GSK-3b

KW - bioenergetics

KW - calcium homeostasis

KW - hexokinase 1

KW - mitochondrial metabolism

KW - mitochondrial pyruvate carrier

KW - presenilin

KW - pyruvate

KW - Alzheimer's disease

KW - GSK-3b

KW - bioenergetics

KW - calcium homeostasis

KW - hexokinase 1

KW - mitochondrial metabolism

KW - mitochondrial pyruvate carrier

KW - presenilin

KW - pyruvate

UR - http://hdl.handle.net/10807/306251

U2 - 10.1016/j.celrep.2020.01.060

DO - 10.1016/j.celrep.2020.01.060

M3 - Article

SN - 2211-1247

VL - 30

SP - 2332-2348.e10

JO - Cell Reports

JF - Cell Reports

ER -

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models

Abstract

Keywords

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