Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models

A. Rossi, G. Rigotto, Giustina Valente, Valentina Giorgio, Enrico Basso, R. Filadi, P. Pizzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.
Lingua originaleEnglish
pagine (da-a)2332-2348.e10
RivistaCell Reports
Volume30
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Alzheimer's disease
  • bioenergetics
  • calcium homeostasis
  • GSK-3b
  • pyruvate
  • mitochondrial metabolism
  • mitochondrial pyruvate carrier
  • presenilin
  • hexokinase 1

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