Abstract
Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.
Lingua originale | English |
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pagine (da-a) | 2332-2348.e10 |
Rivista | Cell Reports |
Volume | 30 |
DOI | |
Stato di pubblicazione | Pubblicato - 2020 |
Keywords
- Alzheimer's disease
- bioenergetics
- calcium homeostasis
- GSK-3b
- pyruvate
- mitochondrial metabolism
- mitochondrial pyruvate carrier
- presenilin
- hexokinase 1