Deep Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex in Alcohol Use Disorder Patients: Effects on Dopamine Transporter Availability and Alcohol Intake

Giovanni Addolorato, Giovanni Camardese, Alessandro Giordano, Antonio Gasbarrini, Daniela Di Giuda, Gabriele Angelo Vassallo, Antonio Miceli, Marco Diana

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)

Abstract

Repetitive Transcranial Magnetic Stimulation (rTMS) of the dorsolateral prefrontal cortex may affect neuro-adaptations associated with alcohol use disorder (AUD), potentially influencing craving and alcohol intake. We investigated alcohol intake and dopamine transporter (DAT) availability by Single Photon Emission Computed Tomography (SPECT) in the striatum of AUD patients before and after deep rTMS. Fourteen patients underwent baseline clinical and SPECT assessment. Eleven out of fourteen patients were randomized into two groups for the REAL (n.5) or SHAM (n.6) treatment. Clinical and SPECT evaluations were then carried out after four weeks of rTMS sessions (T1). At baseline, AUD patients showed higher striatal DAT availability than healthy control subjects (HC). Patients receiving the REAL stimulation revealed a reduction in DAT availability at T1, whereas the SHAM-treated group did not. In addition, patients receiving the REAL stimulation had a decrease in alcohol intake. The results of this longitudinal pilot study may suggest a modulatory effect of deep rTMS on dopaminergic terminals and a potential clinical efficacy in reducing alcohol intake in AUD patients. Further investigations are required to confirm these preliminary data.
Lingua originaleEnglish
pagine (da-a)450-461
Numero di pagine12
RivistaEuropean Neuropsychopharmacology
Volume27
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • 123I-FP-CIT
  • Alcohol dependence
  • Biological Psychiatry
  • Dopamine transporter
  • Dorsolateral prefrontal cortex
  • Neurology
  • Neurology (clinical)
  • Pharmacology
  • Pharmacology (medical)
  • Psychiatry and Mental Health
  • Single photon emission computed tomography
  • Transcranial magnetic stimulation

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