Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti; Enrica Tamburrini; Enzo Ragazzoni; Andrea De Luca; Pierluigi Navarra

doi:10.3851/IMP1473

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti
, Enrica Tamburrini
, Enzo Ragazzoni
, Andrea De Luca
, Pierluigi Navarra

Risultato della ricerca: Contributo in rivista › Articolo

14 Citazioni (Scopus)

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

Lingua originale	Inglese
pagine (da-a)	127-129
Numero di pagine	3
Rivista	Antiviral Therapy
Volume	15
Numero di pubblicazione	1
DOI	https://doi.org/10.3851/IMP1473
Stato di pubblicazione	Pubblicato - 2010

Keywords

Combination
Drug Resistance
Drug Therapy
Female
Fetal Blood
HIV Infections
HIV Protease Inhibitors
HIV-1
Humans
Infant
Infectious
Infectious Disease Transmission
Multiple
Newborn
Pregnancy
Pregnancy Complications
RNA
Ritonavir
Sulfonamides
Vertical
Viral
Young Adult

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AU - Tamburrini, Enrica

AU - Ragazzoni, Enzo

AU - De Luca, Andrea

AU - Navarra, Pierluigi

PY - 2010

Y1 - 2010

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Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Abstract

Keywords

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