Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti; Enrica Tamburrini; Enzo Ragazzoni; Andrea De Luca; Pierluigi Navarra

doi:10.3851/IMP1473

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti, Enrica Tamburrini, Enzo Ragazzoni, Andrea De Luca, Pierluigi Navarra

Risultato della ricerca: Contributo in rivista › Articolo in rivista

14 Citazioni (Scopus)

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

Lingua originale	English
pagine (da-a)	127-129
Numero di pagine	3
Rivista	Antiviral Therapy
Volume	15
DOI	https://doi.org/10.3851/IMP1473
Stato di pubblicazione	Pubblicato - 2010

Keywords

Drug Resistance, Multiple, Viral
Drug Therapy, Combination
Female
Fetal Blood
HIV Infections
HIV Protease Inhibitors
HIV-1
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Pregnancy
Pregnancy Complications, Infectious
RNA, Viral
Ritonavir
Sulfonamides
Young Adult

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abstract = "We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.",

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T1 - Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

AU - Pinnetti, Carmela

AU - Tamburrini, Enrica

AU - Ragazzoni, Enzo

AU - De Luca, Andrea

AU - Navarra, Pierluigi

PY - 2010

Y1 - 2010

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AB - We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

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KW - Fetal Blood

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KW - HIV Protease Inhibitors

KW - HIV-1

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KW - Infant, Newborn

KW - Infectious Disease Transmission, Vertical

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - RNA, Viral

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KW - Fetal Blood

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KW - HIV Protease Inhibitors

KW - HIV-1

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KW - Infant, Newborn

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KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - RNA, Viral

KW - Ritonavir

KW - Sulfonamides

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JO - Antiviral Therapy

JF - Antiviral Therapy

ER -

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Abstract

Keywords

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