Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Enrica Tamburrini, Pierluigi Navarra, Carmela Pinnetti, Enzo Ragazzoni, Andrea De Luca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.
Lingua originaleEnglish
pagine (da-a)127-129
Numero di pagine3
RivistaAntiviral Therapy
Volume15
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Drug Resistance, Multiple, Viral
  • Drug Therapy, Combination
  • Female
  • Fetal Blood
  • HIV Infections
  • HIV Protease Inhibitors
  • HIV-1
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Pregnancy
  • Pregnancy Complications, Infectious
  • RNA, Viral
  • Ritonavir
  • Sulfonamides
  • Young Adult

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